DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT6 and Cct6a

DIOPT Version :9

Sequence 1:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_033968.2	Gene:	Cct6a / 12466	MGIID:	107943	Length:	531	Species:	Mus musculus

Alignment Length:	533	Identity:	370/533 - (69%)
Similarity:	459/533 - (86%)	Gaps:	2/533 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASISLLNPKAEFARAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLH 65
            ||::..||||||.|||..|||:|||||:|||||:|||||||||:|||||||||||:|||||||||
Mouse     1 MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLH 65

  Fly    66 EMQIQHPTASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKARDKA 130
            ||||||||||:||:.:|||||.||||||:.|::|||||||||:|:||||||||:|:|||.|::||
Mouse    66 EMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKA 130

  Fly   131 LEVLDQVKVPVEINKKNLVEVANTSLKTKVHPALADLLTDVCVNAVLTIASADKTKPVDLHMVEL 195
            |:.|:||||..|::::.|::||.|||:||||..|||:||:..|:::|.|...|  :|:||.|||:
Mouse   131 LQFLEQVKVSKEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIRKKD--EPIDLFMVEI 193

  Fly   196 MEMQHKSDTDTQLVRGLVMDHGARHPDMPKRLENAYILTANVSLEYEKAEVNSGFFYKTAEEREA 260
            |||:|||:|||.|:||||:|||||||||.||:|||||||.||||||||.|||||||||:|||||.
Mouse   194 MEMKHKSETDTSLIRGLVLDHGARHPDMKKRVENAYILTCNVSLEYEKTEVNSGFFYKSAEEREK 258

  Fly   261 FVRAEREFIDQRVKKVIELKRSVCDGTDKTFVLINQKGIDPISLDALAKEGILALRRAKRRNMER 325
            .|:|||:||:.||||:||||:.||..:||.||:||||||||.||||||||||:||||||||||||
Mouse   259 LVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGIVALRRAKRRNMER 323

  Fly   326 LSLACGGTAMNSFDDLQEEHLGYAGVVYEHVLGENKYTFVEDCKNPLSVTILIKGPNKHTITQIK 390
            |:|||||.|:||||||..:.||:|.:|||:.|||.|:||:|.|.||.|||:|:|||||||:||||
Mouse   324 LTLACGGIALNSFDDLNPDCLGHAELVYEYTLGEEKFTFIEKCNNPRSVTLLVKGPNKHTLTQIK 388

  Fly   391 DAIRDGLRAINNTIADKALVPGAGAFEVRAYNELVAFKDTIKGKSRLAVQAFADALLVIPKTLAV 455
            |||||||||:.|.|.|..:||||||.||.....|:.:|.::||:::|.|||||||||:|||.||.
Mouse   389 DAIRDGLRAVKNAIDDGCVVPGAGAVEVALAEALIKYKPSVKGRAQLGVQAFADALLIIPKVLAQ 453

  Fly   456 NSGYDAQDTIVKLTVEDRLSPELVGLDLATGEPMKPVDLGVYDNYIVKKQILNSCSIIASNLLLV 520
            |||:|.|:|:||:..|...|.:|||:||:|||||...::||:|||.||||:|:||::||:|:|||
Mouse   454 NSGFDLQETLVKVQAEHSESGQLVGVDLSTGEPMVAAEMGVWDNYCVKKQLLHSCTVIATNILLV 518

  Fly   521 DEVMRAGMTSLKG 533
            ||:|||||:||||
Mouse   519 DEIMRAGMSSLKG 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	365/528 (69%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	362/520 (70%)
Cct6a	NP_033968.2	chap_CCT_zeta	3..530	CDD:274088	365/528 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	710	1.000	Domainoid score	I118
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1336
Inparanoid	1	1.050	761	1.000	Inparanoid score	I544
Isobase	1	0.950	-	0	Normalized mean entropy	S136
OMA	1	1.010	-	-		QHG54122
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	1	1.000	-	-		FOG0003188
OrthoInspector	1	1.000	-	-		otm42618
orthoMCL	1	0.900	-	-		OOG6_101716
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1491
SonicParanoid	1	1.000	-	-		X2146
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.960