DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT6 and Cct3

DIOPT Version :9

Sequence 1:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_033966.1	Gene:	Cct3 / 12462	MGIID:	104708	Length:	545	Species:	Mus musculus

Alignment Length:	522	Identity:	157/522 - (30%)
Similarity:	285/522 - (54%)	Gaps:	16/522 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NPKAEFARAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLHEMQIQHP 72
            |.|.|..|..|  :.||:|||.:.|::||.||||..:|||:...|.|.:|.|||.:|.|:|:|||
Mouse    13 NTKRESGRKVQ--SGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHP 75

  Fly    73 TASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKARDKALEVLDQV 137
            .|..:...|..||:..|||||:.::|.||:|..|:.:|.:.:||.::...:..|.|..:..|.::
Mouse    76 AAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRMALDDMISTLKKI 140

  Fly   138 KVPVEINKKN-LVEVANTSLKTKVHPALADLLTDVCVNAVLTIASADK-TKPVDLHMVELME-MQ 199
            ..||::|.:. ::.:.|:|:.|||....:.|..::.::||.|:...:. .|.:|:.....:| :.
Mouse   141 STPVDVNNREMMLSIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIP 205

  Fly   200 HKSDTDTQLVRGLVMDHGARHPDMPKRLENAYILTANVSLEYEKAEVNSGFFYKTAEEREAFVRA 264
            .....|:.::||::::....||.|.:.::|..|:..:.||||:|.|..:.......|:....::.
Mouse   206 GGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQM 270

  Fly   265 EREFIDQRVKKVIELKRSVCDGTDKTFVLINQKGIDPISLDALAKEGILALRRAKRRNMERLSLA 329
            |.|:|.|..:.:|:||..         |:|.:|||..::...|.:..:.|:||.::.:..|::.|
Mouse   271 EEEYIHQLCEDIIQLKPD---------VVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARA 326

  Fly   330 CGGTAMNSFDDLQEEHLGY-AGVVYEHVLGENKYTFVEDCKNPLSVTILIKGPNKHTITQIKDAI 393
            ||...::..::|:|:.:|. ||::....:|:..:||:.|||:|.:.|||::|.:|..:::::..:
Mouse   327 CGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNL 391

  Fly   394 RDGLRAINNTIADKALVPGAGAFEVRAYNELVAFKDTIKGKSRLAVQAFADALLVIPKTLAVNSG 458
            :|.::...|.:.|..||||.||.|:...:.|......:.|..:...:|.|.||.|||:||..|.|
Mouse   392 QDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCG 456

  Fly   459 YDAQDTIVKLTVE-DRLSPELVGLDLATGEPMKPVDLGVYDNYIVKKQILNSCSIIASNLLLVDE 522
            ......:..|..: .:.|.|..|::..||..:...:||:::...||.|...:....|..||.:|:
Mouse   457 ASTIRLLTSLRAKHTQESCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDD 521

  Fly   523 VM 524
            ::
Mouse   522 IV 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	157/522 (30%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	157/522 (30%)
Cct3	NP_033966.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		5/12 (42%)
		chap_CCT_gamma	6..529	CDD:274085	157/522 (30%)
		TCP1_gamma	6..525	CDD:239453	157/522 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..545
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810