DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT6 and cct6a

DIOPT Version :9

Sequence 1:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_958447.1	Gene:	cct6a / 116994	ZFINID:	ZDB-GENE-011018-2	Length:	531	Species:	Danio rerio

Alignment Length:	533	Identity:	366/533 - (68%)
Similarity:	456/533 - (85%)	Gaps:	2/533 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASISLLNPKAEFARAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLH 65
            ||::..||||||.|||..|||:|||||:|||||:::|||||||:|||||||||||:|||||||||
Zfish     1 MAAVKALNPKAEVARAHAALAVNISAARGLQDVLKSNLGPKGTMKMLVSGAGDIKLTKDGNVLLH 65

  Fly    66 EMQIQHPTASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKARDKA 130
            ||||||||||:||:.:|||||.||||||:.|::|||||||||:|:|||||||::.:|||.|:|||
Zfish    66 EMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYVSEGLHPRVIAEGFEAAKDKA 130

  Fly   131 LEVLDQVKVPVEINKKNLVEVANTSLKTKVHPALADLLTDVCVNAVLTIASADKTKPVDLHMVEL 195
            |.||::|||..|::::.|:.||.|||:||||..||||||:..|:|||.|...:  :|:||:|||:
Zfish   131 LAVLEEVKVAKEMDRETLINVARTSLRTKVHTELADLLTEAVVDAVLAIRKPN--EPIDLYMVEI 193

  Fly   196 MEMQHKSDTDTQLVRGLVMDHGARHPDMPKRLENAYILTANVSLEYEKAEVNSGFFYKTAEEREA 260
            |||:||:|:||||:||||:|||||||||.||:|:|:|||.||||||||.|||||||||:|:||:.
Zfish   194 MEMKHKTDSDTQLIRGLVLDHGARHPDMKKRIEDAFILTCNVSLEYEKTEVNSGFFYKSADERDK 258

  Fly   261 FVRAEREFIDQRVKKVIELKRSVCDGTDKTFVLINQKGIDPISLDALAKEGILALRRAKRRNMER 325
            .|:|||:||:.||.|:|:||..||....|.||:||||||||.||||||||||:||||||||||||
Zfish   259 LVKAERKFIEDRVMKIIDLKNKVCADNKKGFVVINQKGIDPFSLDALAKEGIVALRRAKRRNMER 323

  Fly   326 LSLACGGTAMNSFDDLQEEHLGYAGVVYEHVLGENKYTFVEDCKNPLSVTILIKGPNKHTITQIK 390
            |:|||||.||||.:||..|.||:||:|||:.|||.|:||:|:|.||.|||:|:|||||||:||||
Zfish   324 LTLACGGVAMNSVEDLTPECLGHAGLVYEYTLGEEKFTFIENCSNPRSVTLLVKGPNKHTLTQIK 388

  Fly   391 DAIRDGLRAINNTIADKALVPGAGAFEVRAYNELVAFKDTIKGKSRLAVQAFADALLVIPKTLAV 455
            ||:||||||:.|.|.|.::|.|||||||...:.||..|..:||:::|.|||||||||||||.||.
Zfish   389 DAVRDGLRAVKNAIEDGSVVAGAGAFEVAVADALVKHKPKVKGRAQLGVQAFADALLVIPKVLAQ 453

  Fly   456 NSGYDAQDTIVKLTVEDRLSPELVGLDLATGEPMKPVDLGVYDNYIVKKQILNSCSIIASNLLLV 520
            |||||.|:|:|||..|.:.:.:|||:||:|||||...:.||:|||.||||:|:||::||||:|||
Zfish   454 NSGYDPQETLVKLQSEFKEAGQLVGVDLSTGEPMVAGEAGVWDNYSVKKQLLHSCTVIASNILLV 518

  Fly   521 DEVMRAGMTSLKG 533
            ||:|||||:||||
Zfish   519 DEIMRAGMSSLKG 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	361/528 (68%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	358/520 (69%)
cct6a	NP_958447.1	chap_CCT_zeta	3..530	CDD:274088	361/528 (68%)
cct6a	NP_958447.1	TCP1_zeta	7..526	CDD:239458	358/520 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574846
Domainoid	1	1.000	686	1.000	Domainoid score	I132
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1336
Inparanoid	1	1.050	735	1.000	Inparanoid score	I589
OMA	1	1.010	-	-		QHG54122
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	1	1.000	-	-		FOG0003188
OrthoInspector	1	1.000	-	-		oto40523
orthoMCL	1	0.900	-	-		OOG6_101716
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1491
SonicParanoid	1	1.000	-	-		X2146
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940