DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT6 and CCT8

DIOPT Version :9

Sequence 1:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_006576.2	Gene:	CCT8 / 10694	HGNCID:	1623	Length:	548	Species:	Homo sapiens

Alignment Length:	552	Identity:	145/552 - (26%)
Similarity:	242/552 - (43%)	Gaps:	64/552 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PKA------------EFARAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGN 61
            |||            .|:...:|:..||.|.|.|....||..||.|..||:::....:.:|.|..
Human     6 PKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAA 70

  Fly    62 VLLHEMQIQHPTASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKA 126
            .:|.|:::|||.|.||..||..|:...||||...::..|.||:.|:..|..||....:.:|:|.|
Human    71 TILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIA 135

  Fly   127 RDKALEVLDQVKVPVEINKKNLVEVAN---TSLKTKVH---PALADLLTDVCVN----------- 174
            ..||.|:|..:......|.:::.||::   ||:.:|.:   ..||.|:...||:
Human   136 CRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLAKLIAQACVSIFPDSGHFNVD 200

  Fly   175 --AVLTIASADKTKPVDLHMVELMEMQHKSDTDTQLVRGLVMDHGARHPDMPKRLENAYILTANV 237
              .|..|..:..:....||     .|..|.:|:..:.                .:::|.|...:.
Human   201 NIRVCKILGSGISSSSVLH-----GMVFKKETEGDVT----------------SVKDAKIAVYSC 244

  Fly   238 SLEYEKAEVNSGFFYKTAEEREAFVRAEREFIDQRVKKVIELKRSVCDGTDKTFVLINQKGIDPI 302
            ..:....|.......|||||...|.:.|...:|.:||.:.:        |....|:...|..| :
Human   245 PFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIAD--------TGANVVVTGGKVAD-M 300

  Fly   303 SLDALAKEGILALRRAKRRNMERLSLACGGTAMNSFDDLQEEHLGYAGVVYEHVLGENK-YTFVE 366
            :|....|..|:.:|...:.::.||....|.||:........|.:|:...||...:|:.: ..|..
Human   301 ALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKH 365

  Fly   367 DCKNPLSVTILIKGPNKHTITQIKDAIRDGLRAINNTIADKALVPGAGAFEVRAYNELVAFKDTI 431
            :.::....||:::|...:.:..|:.|:.||:........||.||||.||.|:....::.::.:|.
Human   366 EKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETC 430

  Fly   432 KGKSRLAVQAFADALLVIPKTLAVNSGYDAQDTIVKLTVEDRLSPELVGLDLATGEP--MKPVDL 494
            .|..:.|::.||:|...||:.||.|||..|.:.|.||....:...:.||||:....|  ...::.
Human   431 PGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEA 495

  Fly   495 GVYDNYIVKKQILNSCSIIASNLLLVDEVMRA 526
            |:.|.|:.|...:...:..|..:|.||:::.|
Human   496 GILDTYLGKYWAIKLATNAAVTVLRVDQIIMA 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	145/552 (26%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	145/552 (26%)
CCT8	NP_006576.2	chap_CCT_theta	10..539	CDD:274087	142/548 (26%)
CCT8	NP_006576.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..548
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010