Protein Alignment CCT6 and CCT2

DIOPT Version :10

• Sequence 1: NP_573066.1
• Gene: CCT6 / 32518
• FlyBaseID: FBgn0027329
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_006422.1
• Gene: CCT2 / 10576
• HGNCID: 1615
• Length: 535
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 146/544 - (26%)
• Similarity: 272/544 - (50%)
• Gaps: 44/544 - (8%)

  Fly     1 MASISLLNPKAEFARAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGD--IKITKDGNVL 63
            :|.:::....|:..||..|...:...|..:.|::::.|||||..|:|:|...|  :.:|.||..:
Human     6 LAPVNIFKAGADEERAETARLTSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATI 70

  Fly    64 LHEMQIQHPTASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKARD 128
            |..:.:.:|.|.::...|..|||..|||||:..:|..|||::|:..:::.:||:.:..|:.:|..
Human    71 LKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATK 135

  Fly   129 KALEVL---------DQVKVPVEINKKNLVEVANTSLKTKVHPALADLLTDVCVNAVLTIASADK 184
            .|.|.|         |:||.     :::|:.:|.|:|.:|:.....|..|.:.|.|||.:..:.
Human   136 AAREALLSSAVDHGSDEVKF-----RQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSG- 194

  Fly   185 TKPVDLHMVELMEMQHKSDTDTQLVRGLVMDH--GARHPDMPKRLENAYILTANVSLEYEKAEVN 247
                :|..:.:::....|..|:.|..|.::|.  |.   :.|||:|||.||.||..::.:|.::
Human   195 ----NLEAIHIIKKLGGSLADSYLDEGFLLDKKIGV---NQPKRIENAKILIANTGMDTDKIKI- 251

  Fly   248 SGFFYKTAEEREAFV----RAEREFIDQRVKKVIELKRSV-CDGTDKTFVLINQKGIDPISLDAL 307
              |..:...:..|.|    .||:|.:.::|:::  ||..: |        .||::.|........
Human   252 --FGSRVRVDSTAKVAEIEHAEKEKMKEKVERI--LKHGINC--------FINRQLIYNYPEQLF 304

  Fly   308 AKEGILALRRAKRRNMERLSLACGGTAMNSFDDLQEEHLGYAGVVYEHVLGENKYTFVEDCKNPL 372
            ...|::|:..|....:|||:|..||...::||..:...||...::.|.::||:|...........
Human   305 GAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGE 369

  Fly   373 SVTILIKGPNKHTITQIKDAIRDGLRAINNTIADKALVPGAGAFEVRAYNELVAFKDTIKGKSRL 437
            :.||:::|..:..:.:.:.::.|.|..:..|:.|...|.|.|..|:...:.:....:...||..:
Human   370 ACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEAV 434

  Fly   438 AVQAFADALLVIPKTLAVNSGYDAQDTIVKLTVEDRLSPELVGLDLATGEPMKPVDLGVYDNYIV 502
            |::::|.||.::|..:|.|:|||:.|.:.:|...........|||:..|.......||:.:::.|
Human   435 AMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTTAGLDMREGTIGDMAILGITESFQV 499

  Fly   503 KKQILNSCSIIASNLLLVDEVMRA 526
            |:|:|.|.:..|..:|.||.:::|
Human   500 KRQVLLSAAEAAEVILRVDNIIKA 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	145/538 (27%)
CCT2	NP_006422.1	TCP1_beta	11..527	CDD:239452	145/539 (27%)