DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT6 and CCT7

DIOPT Version :9

Sequence 1:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_006420.1	Gene:	CCT7 / 10574	HGNCID:	1622	Length:	543	Species:	Homo sapiens

Alignment Length:	530	Identity:	140/530 - (26%)
Similarity:	253/530 - (47%)	Gaps:	22/530 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISLLNPKAEFARAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLHEMQ 68
            :.||....:.::....|..||||.:.:.:.:||.|||:|..|::|.|.|...|:.||..:|..:.
Human     6 VILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLD 70

  Fly    69 IQHPTASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKARDKALEV 133
            :.||.|..:...:.:||...|||||:..:|..|.|||...|:.|||||:|:...|..|...|:..
Human    71 VVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNK 135

  Fly   134 LDQVKVPV----EINKKNLVE-VANTSLKTKVHPALADLLTDVCVNAVLTIASADKTKPVDLHMV 193
            :.::.|.|    ::.::.|:| .|.|:|.:|:..........:.|:||:.:...     :.|.|:
Human   136 IKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMMLDDL-----LQLKMI 195

  Fly   194 ELMEMQHKSDTDTQLVRGLVMDHG---ARHPDMPKRLENAYILTANVSLEYEKAEVNSGFFYKTA 255
            .:.::|..:..|:|||.|:.....   |.....||:..|..|...||.||.:..:.|:.....|.
Human   196 GIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVHTV 260

  Fly   256 EEREAFVRAEREFIDQRVKKVIELKRSVCDGTDKTFVLINQKGIDPISLDALAKEGILALRRAKR 320
            |:.:|.|.||...:..:::|:..      .|..   |::::..|..::....|...:....|...
Human   261 EDYQAIVDAEWNILYDKLEKIHH------SGAK---VVLSKLPIGDVATQYFADRDMFCAGRVPE 316

  Fly   321 RNMERLSLACGGTAMNSFDDLQEEHLGYAGVVYEHVLGENKYTFVEDCKNPLSVTILIKGPNKHT 385
            .:::|..:||||:...|.:.|..:.||...|..|..:|..:|.|...|....:.|.:::|..:..
Human   317 EDLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNFFTGCPKAKTCTFILRGGAEQF 381

  Fly   386 ITQIKDAIRDGLRAINNTIADKALVPGAGAFEVRAYNELVAFKDTIKGKSRLAVQAFADALLVIP 450
            :.:.:.::.|.:..:...|.:.::|.|.||.|:.....|..:..||.||.:|.:.|:|.||.:||
Human   382 MEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIP 446

  Fly   451 KTLAVNSGYDAQDTIVKLTVEDRLSPELVGLDLATGEPMKPVDLGVYDNYIVKKQILNSCSIIAS 515
            :.|..|:|:||.:.:.||...........|:|:...:.....:..|::..:|:...|.:.|..|.
Human   447 RQLCDNAGFDATNILNKLRARHAQGGTWYGVDINNEDIADNFEAFVWEPAMVRINALTAASEAAC 511

  Fly   516 NLLLVDEVMR 525
            .::.|||.::
Human   512 LIVSVDETIK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	140/530 (26%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	139/527 (26%)
CCT7	NP_006420.1	TCP1_eta	5..525	CDD:239456	140/530 (26%)
CCT7	NP_006420.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..543
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810