DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8944 and ZNF235

DIOPT Version :10

Sequence 1:NP_573065.1 Gene:CG8944 / 32517 FlyBaseID:FBgn0030680 Length:762 Species:Drosophila melanogaster
Sequence 2:NP_004225.3 Gene:ZNF235 / 9310 HGNCID:12866 Length:738 Species:Homo sapiens


Alignment Length:768 Identity:175/768 - (22%)
Similarity:277/768 - (36%) Gaps:219/768 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 MQTVH--------LGD----QSVANTSSRLPFNLGEPMSLSGRNGDLPNFHEIEDLTDADTALLE 107
            |.|:|        ||:    |...:.:|:|..:....:::.|::...|..|              
Human    87 MATLHKAGLRCFSLGELSCWQIKRHIASKLARSQDSMINIEGKSSQFPKHH-------------- 137

  Fly   108 PQMVIKQELQDLPCSDDDVVAGEE-----DDD--EQRLNDSEADEDEAILPESDVPVVSSKTRAR 165
                      |.||   .|.|||.     ||:  ...:.|..:..:....|...||...||....
Human   138 ----------DSPC---QVGAGESIQASVDDNCLVNHIGDHSSIIENQEFPTGKVPNSWSKIYLN 189

  Fly   166 KKVTKQR---QRDMSSELLIAGDGDSSMDDYGDPDHSYMDDNSGEYMDFAGFDGVNHSGFGTESD 227
            :....||   |..|.::|.|..   ..:|.:....|.: |||            :.|        
Human   190 ETQNYQRSCKQTQMKNKLCIFA---PYVDIFSCISHHH-DDN------------IVH-------- 230

  Fly   228 FLSYDEMVEESLLGRDREVTMHIKDRKMIQFLIHSYQRNPFLWDHGNAQFRDRVKRARFLDWIVL 292
              ..|::...|..|:|.     :|...:.|..||:          |...::.......|.|...|
Human   231 --KRDKVHSNSDCGKDT-----LKVSPLTQRSIHT----------GQKTYQGNECEEAFNDSSSL 278

  Fly   293 EFKSRFNISLAKDAI-TRKWD-----------NLRTVYKR----ECNRMALEKTNISTLWYFKEL 341
            |...:.::.....|. |.:.|           ::||..||    ||.:...:.:|:.|   .:.:
Human   279 ELHKQVHLGKKSPACSTHEKDTSYSSGIPVQQSVRTGKKRYWCHECGKGFSQSSNLQT---HQRV 340

  Fly   342 HFLNEVY-------SYNDKMS-----DAVVKETSYR-----RRFSAIWNDTSTAKLLSMVKRYQC 389
            |...:.|       |:|....     .....|..||     :.||...:.....::.:..|.|:|
Human   341 HTGEKPYTCHECGKSFNQSSHLYAHLPIHTGEKPYRCDSCGKGFSRSTDLNIHCRVHTGEKPYKC 405

  Fly   390 FYNRFDPDYRSKERRGEGLHQMAIELQQLIDVTTIQISKRISQLRFDYSKQKMERLNSERLGKKF 454
                        |..|:|..|.          :.:|..:||      ::.:|..:...  .||:|
Human   406 ------------EVCGKGFTQR----------SHLQAHERI------HTGEKPYKCGD--CGKRF 440

  Fly   455 --IANYLYYDQMHFMDDDIPPFKCAHCPEIVQTLRELDLHMLTH---QPSLGGGYYCNICSIQFH 514
              .:|...:.::|   .:..|:||..|.:.......|..|...|   :|     |.|..|...|.
Human   441 SCSSNLHTHQRVH---TEEKPYKCDECGKCFSLSFNLHSHQRVHTGEKP-----YKCEECGKGFS 497

  Fly   515 NAQEFDNHKQLHLGGVTEIKFNCELCTASFREKANYDEHLRRHNEE----------LFLPSLAL- 568
            :|..|.:|:::|.|   |..|.|.:|...|.:.:.:..|.|.|..|          .|..||.| 
Human   498 SASSFQSHQRVHTG---EKPFRCNVCGKGFSQSSYFQAHQRVHTGEKPYKCEVCGKRFNWSLNLH 559

  Fly   569 NHSIMEGGLGDDEIGVEGEE-SRG-SGSRRKRRHAAKATDDMVDDDDRIGGGGGGGSGGGGTDIA 631
            ||..:..|    |...:.|| .:| |.:...:.|.:..|.:                        
Human   560 NHQRVHTG----EKPYKCEECGKGFSQASNLQAHQSVHTGE------------------------ 596

  Fly   632 KPYGCDVCRRSFATPGHLNAHRIVHQDERERCYKCDYPQCNKSFVARNSLFEHLKQHYSNEEFKC 696
            ||:.||.|::.|:...||.||:.||..|:.  ||||  .|.|:|..|::|..|...|...:.|||
Human   597 KPFKCDACQKRFSQASHLQAHQRVHTGEKP--YKCD--TCGKAFSQRSNLQVHQIIHTGEKPFKC 657

  Fly   697 DICGKTFKSTKNLQNHKQIHDKIKRYVCQICGSAFAQAAGLYLHKRRH--NRP 747
            :.|||.|..:..|..|:::|...|.|.||.||..|:||:..:.|:|.|  .||
Human   658 EECGKEFSWSAGLSAHQRVHTGEKPYTCQQCGKGFSQASHFHTHQRVHTGERP 710

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8944NP_573065.1 MADF_DNA_bdg 259..344 CDD:463144 19/100 (19%)
MADF 379..472 CDD:214738 16/94 (17%)
C2H2 Zn finger 476..496 CDD:275368 4/19 (21%)
C2H2 Zn finger 506..526 CDD:275368 6/19 (32%)
C2H2 Zn finger 537..557 CDD:275368 5/19 (26%)
C2H2 Zn finger 636..656 CDD:275368 8/19 (42%)
COG5048 <666..734 CDD:227381 26/67 (39%)
C2H2 Zn finger 666..688 CDD:275368 8/21 (38%)
C2H2 Zn finger 696..716 CDD:275368 7/19 (37%)
C2H2 Zn finger 724..744 CDD:275368 9/19 (47%)
ZNF235NP_004225.3 KRAB A domain 6..47
KRAB 8..68 CDD:214630
KRAB B domain 48..80
C2H2 Zn finger 239..257 CDD:275370 5/22 (23%)
C2H2 Zn finger 266..285 CDD:275368 4/18 (22%)
COG5048 321..662 CDD:227381 97/416 (23%)
C2H2 Zn finger 321..341 CDD:275368 4/22 (18%)
zinc finger domain 321..341 4/22 (18%)
C2H2 Zn finger 349..369 CDD:275368 2/19 (11%)
zinc finger domain 349..369 2/19 (11%)
C2H2 Zn finger 377..397 CDD:275368 2/19 (11%)
zinc finger domain 377..397 2/19 (11%)
C2H2 Zn finger 405..425 CDD:275368 8/47 (17%)
zinc finger domain 405..425 8/47 (17%)
C2H2 Zn finger 433..453 CDD:275368 4/21 (19%)
zinc finger domain 433..453 4/21 (19%)
C2H2 Zn finger 461..481 CDD:275368 4/19 (21%)
zinc finger domain 461..481 4/19 (21%)
C2H2 Zn finger 489..509 CDD:275368 6/19 (32%)
zinc finger domain 489..509 6/19 (32%)
C2H2 Zn finger 517..537 CDD:275368 5/19 (26%)
zinc finger domain 517..537 5/19 (26%)
C2H2 Zn finger 545..565 CDD:275368 6/19 (32%)
zinc finger domain 545..565 6/19 (32%)
C2H2 Zn finger 573..593 CDD:275368 5/19 (26%)
zinc finger domain 573..593 5/19 (26%)
C2H2 Zn finger 601..621 CDD:275368 8/19 (42%)
zinc finger domain 601..621 8/19 (42%)
C2H2 Zn finger 629..649 CDD:275368 8/21 (38%)
zinc finger domain 629..649 8/21 (38%)
C2H2 Zn finger 657..677 CDD:275368 7/19 (37%)
zinc finger domain 657..677 7/19 (37%)
C2H2 Zn finger 685..705 CDD:275368 9/19 (47%)
zinc finger domain 685..705 9/19 (47%)
C2H2 Zn finger 713..733 CDD:275368
zinc finger domain 713..733
Blue background indicates that the domain is not in the aligned region.

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