DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8944 and ZNF208

DIOPT Version :9

Sequence 1:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	NP_009084.2	Gene:	ZNF208 / 7757	HGNCID:	12999	Length:	1280	Species:	Homo sapiens

Alignment Length:	449	Identity:	102/449 - (22%)
Similarity:	171/449 - (38%)	Gaps:	112/449 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 STLWYFKELHFLNEVYSYND-----KMSDAVVK-------ETSYR-----RRFSAIWNDTSTAKL 380
            |||.|.|::|.:.:.|...:     ..|..::|       |..|:     :.||.:...|:...:
Human   762 STLSYHKKIHTVEKPYKCEECGKAFNRSAILIKHKRIHTDEKPYKCEECGKTFSKVSTLTTHKAI 826

  Fly   381 LSMVKRYQCFYNRFDPDYRSKERRGEGLHQMAIELQQLIDVTTIQISKRISQLRFDYSKQKMERL 445
            .:..|.|:|            :..|:...:.:|                :::.:..::.:|..:
Human   827 HAGEKPYKC------------KECGKAFSKFSI----------------LTKHKVIHTGEKPYK- 862

  Fly   446 NSERLGK--KFIANYLYYDQMHFMDDDIPPFKCAHCPEIVQTLRELDLHMLTH---QPSLGGGYY 505
             .|..||  |:.:...|:.::|..:   .|:||..|.:.......|..|.:.|   :|     |.
Human   863 -CEECGKAYKWPSTLSYHKKIHTGE---KPYKCEECGKGFSMFSILTKHEVIHTGEKP-----YK 918

  Fly   506 CNICSIQFHNAQEFDNHKQLHLGGVTEIKFNCELCTASFREKANYDEHLRRHNEE---------- 560
            |..|...|.....|..||:.|.|   |..:.||.|..:::..:....|.:.|.||
Human   919 CEECGKAFSWLSVFSKHKKTHAG---EKFYKCEACGKAYKSSSTLSYHKKIHTEEKPYKYEECGK 980

  Fly   561 ---LFLPSLALNHSIMEGGLGDDEIGVEGEESRGSGS--RRKRRHAAKATDDMVDDDDRIGGGGG 620
               .|  |:...|.::..|....:....|:....|.:  ..|:.|..:.
Human   981 GFSTF--SILTKHKVIHTGEKPYKCEECGKAFNWSSNLMEHKKIHTGET---------------- 1027

  Fly   621 GGSGGGGTDIAKPYGCDVCRRSFATPGHLNAHRIVHQDERERCYKCDYPQCNKSFVARNSLFEHL 685
                        ||.|:.|.::|:.|..|..|:..|..|:.  |||:  :|.|:|...:.|.||.
Human  1028 ------------PYKCEECDKAFSWPSSLTEHKATHAGEKP--YKCE--ECGKAFSWPSRLTEHK 1076

  Fly   686 KQHYSNEEFKCDICGKTFKSTKNLQNHKQIHDKIKRYVCQICGSAFAQAAGLYLHKRRH 744
            ..|...|.:||:.|||.|..:.||..||:||...|.|.|:.||.:|:..:.|..||..|
Human  1077 ATHAGEEPYKCEECGKAFNWSSNLMEHKRIHTGEKPYKCEECGKSFSTFSILTKHKVIH 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510	6/10 (60%)
		MADF	379..472	CDD:214738	12/94 (13%)
		C2H2 Zn finger	476..496	CDD:275368	4/19 (21%)
		C2H2 Zn finger	506..526	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	4/19 (21%)
		C2H2 Zn finger	636..656	CDD:275368	6/19 (32%)
		zf-C2H2_8	639..712	CDD:292531	26/72 (36%)
		C2H2 Zn finger	666..688	CDD:275368	7/21 (33%)
		zf-C2H2	694..716	CDD:278523	10/21 (48%)
		C2H2 Zn finger	696..716	CDD:275368	9/19 (47%)
		zf-H2C2_2	708..733	CDD:290200	12/24 (50%)
		C2H2 Zn finger	724..744	CDD:275368	7/19 (37%)
ZNF208	NP_009084.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		COG5048	227..619	CDD:227381
		C2H2 Zn finger	231..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		C2H2 Zn finger	287..307	CDD:275368
		C2H2 Zn finger	315..335	CDD:275368
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		zf-H2C2_2	384..407	CDD:290200
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368
		zf-H2C2_2	439..463	CDD:290200
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	499..519	CDD:275368
		zf-H2C2_2	511..536	CDD:290200
		C2H2 Zn finger	527..547	CDD:275368
		C2H2 Zn finger	555..575	CDD:275368
		zf-H2C2_2	568..592	CDD:290200
		C2H2 Zn finger	583..603	CDD:275368
		zf-H2C2_2	596..619	CDD:290200
		C2H2 Zn finger	611..631	CDD:275368
		C2H2 Zn finger	639..659	CDD:275368
		C2H2 Zn finger	667..687	CDD:275368
		COG5048	691..1133	CDD:227381	100/445 (22%)
		C2H2 Zn finger	695..715	CDD:275368
		zf-H2C2_2	707..732	CDD:290200
		C2H2 Zn finger	723..743	CDD:275368
		C2H2 Zn finger	751..771	CDD:275368	5/8 (63%)
		zf-H2C2_2	764..788	CDD:290200	5/23 (22%)
		C2H2 Zn finger	779..799	CDD:275368	2/19 (11%)
		C2H2 Zn finger	807..827	CDD:275368	3/19 (16%)
		C2H2 Zn finger	835..855	CDD:275368	3/47 (6%)
		C2H2 Zn finger	863..883	CDD:275368	5/19 (26%)
		zf-H2C2_2	876..899	CDD:290200	6/25 (24%)
		C2H2 Zn finger	891..911	CDD:275368	4/19 (21%)
		C2H2 Zn finger	919..939	CDD:275368	6/19 (32%)
		C2H2 Zn finger	947..967	CDD:275368	4/19 (21%)
		C2H2 Zn finger	976..995	CDD:275368	3/20 (15%)
		C2H2 Zn finger	1003..1023	CDD:275368	3/19 (16%)
		zf-H2C2_2	1015..1039	CDD:290200	6/51 (12%)
		C2H2 Zn finger	1031..1051	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1059..1079	CDD:275368	7/21 (33%)
		C2H2 Zn finger	1087..1107	CDD:275368	9/19 (47%)
		zf-H2C2_2	1099..1124	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1115..1135	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1143..1163	CDD:275368
		C2H2 Zn finger	1171..1191	CDD:275368
		C2H2 Zn finger	1199..1219	CDD:275368
		zf-H2C2_2	1212..1236	CDD:290200
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1255..1275	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142375
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930