Protein Alignment CG8944 and ZNF43

DIOPT Version :10

• Sequence 1: NP_573065.1
• Gene: CG8944 / 32517
• FlyBaseID: FBgn0030680
• Length: 762
• Species: Drosophila melanogaster
• Sequence 2: NP_001243582.1
• Gene: ZNF43 / 7594
• HGNCID: 13109
• Length: 818
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 120/528 - (22%)
• Similarity: 191/528 - (36%)
• Gaps: 162/528 - (30%)

  Fly   311 WDNLRTVYKR-----------ECNRMALEKTNISTLWYFKELHFLNEVYSYNDKMSDAVVKETSY 364
            |.:..|.:||           ||.:...:.:|::|   .|.:|...:.|           |.|..
Human   334 WPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTT---HKRIHTAEKFY-----------KCTEC 384

  Fly   365 RRRFSAIWNDTSTAKLLSMVKRYQC-----------------FYNRFDPDYRSKE---------- 402
            ...||...|.|...|:.:..|.|:|                 ..:..:..|:.:|
Human   385 GEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEKPYKCEECGKAFNWPST 449

  Fly   403 -------RRGEGLHQMAI---ELQQLIDVTTIQISKRISQLRFDYSKQKMERLNSERLGKKF--I 455
                   ..||..::..:   ...|..::||   .|||......|        ..|..||.|  .
Human   450 LTKHNRIHTGEKPYKCEVCGKAFNQFSNLTT---HKRIHTAEKPY--------KCEECGKAFSRS 503

  Fly   456 ANYLYYDQMHFMDDDIPPFKCAHCPEIVQTLRELDLHMLTH---QPSLGGGYYCNICSIQFHNAQ 517
            :|...:.::|.   :..|:||..|.:..:...:|..|.:||   :|     |.|..|...|::..
Human   504 SNLTKHKKIHI---EKKPYKCEECGKAFKWSSKLTEHKITHTGEKP-----YKCEECGKAFNHFS 560

  Fly   518 EFDNHKQLHLGGVTEIKFNCELCTASFREKANYDEHLRRHNEELFL------------PSLALNH 570
            ....||::|.|   |..:.||.|..:|.:.:|...|.:.|..|.|.            .:|..:.
Human   561 ILTKHKRIHTG---EKPYKCEECGKAFTQSSNLTTHKKIHTGEKFYKCEECGKAFTQSSNLTTHK 622

  Fly   571 SIMEGG--LGDDEIG--------------VEGEES-----------RGSGSRRKRR--HAAKATD 606
            .|..||  ...:|.|              :..||.           :.|.:..|.:  |..:
Human   623 KIHTGGKPYKCEECGKAFNQFSTLTKHKIIHTEEKPYKCEECGKAFKWSSTLTKHKIIHTGE--- 684

  Fly   607 DMVDDDDRIGGGGGGGSGGGGTDIAKPYGCDVCRRSFATPGHLNAHRIVHQDERERCYKCDYPQC 671
                                     |||.|:.|.::|.....|:.|:|:|..|:.  |||:  :|
Human   685 -------------------------KPYKCEECGKAFKLSSTLSTHKIIHTGEKP--YKCE--KC 720

  Fly   672 NKSFVARNSLFEHLKQHYSNEEFKCDICGKTFKSTKNLQNHKQIHDKIKRYVCQICGSAFAQAAG 736
            .|:|...::|.||.|.|...:.:||:.|||.|..:.:|..||:||.|.:.|.|:.||.||.|.:.
Human   721 GKAFNRSSNLIEHKKIHTGEQPYKCEECGKAFNYSSHLNTHKRIHTKEQPYKCKECGKAFNQYSN 785

  Fly   737 LYLHKRRH 744
            |..|.:.|
Human   786 LTTHNKIH 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:463144	10/43 (23%)
		MADF	379..472	CDD:214738	21/131 (16%)
		C2H2 Zn finger	476..496	CDD:275368	4/19 (21%)
		C2H2 Zn finger	506..526	CDD:275368	5/19 (26%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	636..656	CDD:275368	6/19 (32%)
		COG5048	<666..734	CDD:227381	27/67 (40%)
		C2H2 Zn finger	666..688	CDD:275368	8/21 (38%)
		C2H2 Zn finger	696..716	CDD:275368	8/19 (42%)
		C2H2 Zn finger	724..744	CDD:275368	8/19 (42%)
ZNF43	NP_001243582.1	KRAB	13..72	CDD:214630
		C2H2 Zn finger	158..177	CDD:275370
		C2H2 Zn finger	185..205	CDD:275368
		C2H2 Zn finger	213..233	CDD:275368
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	269..289	CDD:275368
		COG5048	295..763	CDD:227381	106/496 (21%)
		C2H2 Zn finger	297..317	CDD:275368
		C2H2 Zn finger	325..345	CDD:275368	4/10 (40%)
		C2H2 Zn finger	353..373	CDD:275368	5/22 (23%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		C2H2 Zn finger	409..429	CDD:275368	1/19 (5%)
		C2H2 Zn finger	437..457	CDD:275368	1/19 (5%)
		C2H2 Zn finger	465..485	CDD:275368	5/22 (23%)
		C2H2 Zn finger	521..541	CDD:275368	4/19 (21%)
		C2H2 Zn finger	549..569	CDD:275368	5/19 (26%)
		C2H2 Zn finger	577..597	CDD:275368	6/19 (32%)
		C2H2 Zn finger	605..625	CDD:275368	1/19 (5%)
		C2H2 Zn finger	633..653	CDD:275368	2/19 (11%)
		C2H2 Zn finger	661..681	CDD:275368	2/19 (11%)
		C2H2 Zn finger	689..709	CDD:275368	6/19 (32%)
		C2H2 Zn finger	717..737	CDD:275368	8/21 (38%)
		COG5048	742..>803	CDD:227381	22/52 (42%)
		C2H2 Zn finger	745..765	CDD:275368	8/19 (42%)
		C2H2 Zn finger	773..793	CDD:275368	8/19 (42%)