DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8944 and ZNF107

DIOPT Version :9

Sequence 1:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	NP_001374954.1	Gene:	ZNF107 / 51427	HGNCID:	12887	Length:	896	Species:	Homo sapiens

Alignment Length:	482	Identity:	109/482 - (22%)
Similarity:	176/482 - (36%)	Gaps:	150/482 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 YK-RECNRMALEKTNISTLWYFKELHFLNEVYSYNDKMSDAVVKETSYR-----RRFSAIWNDTS 376
            || :||.:...:.:|::.   .|::|                ..|.||:     :.|:...|..:
Human   469 YKCKECGKAFNQSSNLTE---HKKIH----------------TAEKSYKCEECGKAFNQHSNLIN 514

  Fly   377 TAKLLSMVKRYQCFYNRFDPDYRSKERRGEGLHQMAIELQQLIDVTTIQISKRISQLRFDYSKQK 441
            ..|:.|..|.|:|            |..|:..::.          :|:...|:|......|..::
Human   515 HRKIYSGEKPYKC------------EECGKAFNRS----------STLTRHKKIHTGEKPYKCEE 557

  Fly   442 MERLNSERLGKKFIANYLYYDQMHFMDDDIPPFKCAHCPEIVQTLRELDLHMLTH---QPSLGGG 503
            .:|..|:.      :|...:.::|..:   .|:||..|.:.......|..|...|   :|
Human   558 CDRAFSQS------SNLTEHKKIHTGE---KPYKCEECGKAFNRFSTLTKHKRIHTGEKP----- 608

  Fly   504 YYCNICSIQFHNAQEFDNHKQLHLGGVTEIKFN-CELCTASFREKAN---------------YDE 552
            |.|..|...|:.:.:...||.:|    |:.|.| ||....:|::.::               .:|
Human   609 YKCEECGKAFNQSYQLTRHKIVH----TKEKLNKCEEFGKAFKQSSHRTIHKIIHTGEKPYKCEE 669

  Fly   553 H------------------------LRRHNEELFLPSLALNHSIMEGGLGDDEIGVEGEESRGSG 593
            |                        ...|.:...|.|...||.|:..|    |...:.||...:.
Human   670 HGKVFNQSSNLTTQKIIHTGENLYKFEEHGKAFNLFSNITNHKIIYTG----EKPHKCEECGKAY 730

  Fly   594 SR------RKRRHAAKATDDMVDDDDRIGGGGGGGSGGGGTDIAKPYGCDVCRRSFATPGHLNAH 652
            :|      .||.|..:                            |||.|..|.::|.....||.|
Human   731 NRFSNLTIHKRIHTGE----------------------------KPYQCAECGKAFNCSSTLNRH 767

  Fly   653 RIVHQDERERCYKCDYPQCNKSFVARNSLFEHLKQHYSNEEFKCDICGKTFKSTKNLQNHKQIHD 717
            :|:|..|:.  |||  .:|.|:|...::|..|.|.|...:.:||:.|||.|..:.||..||:||.
Human   768 KIIHTGEKP--YKC--KECGKAFNLSSTLTAHKKIHTGEKPYKCEECGKAFNQSSNLTTHKKIHT 828

  Fly   718 KIKRYVCQICGSAFAQAAGLYLHKRRH 744
            ..|.|.|:.||.:|.|.:.|.:||..|
Human   829 SEKPYKCEECGKSFNQFSSLNIHKIIH 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510	7/26 (27%)
		MADF	379..472	CDD:214738	15/92 (16%)
		C2H2 Zn finger	476..496	CDD:275368	4/19 (21%)
		C2H2 Zn finger	506..526	CDD:275368	5/19 (26%)
		C2H2 Zn finger	537..557	CDD:275368	5/58 (9%)
		C2H2 Zn finger	636..656	CDD:275368	7/19 (37%)
		zf-C2H2_8	639..712	CDD:292531	26/72 (36%)
		C2H2 Zn finger	666..688	CDD:275368	7/21 (33%)
		zf-C2H2	694..716	CDD:278523	10/21 (48%)
		C2H2 Zn finger	696..716	CDD:275368	9/19 (47%)
		zf-H2C2_2	708..733	CDD:290200	12/24 (50%)
		C2H2 Zn finger	724..744	CDD:275368	8/19 (42%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630
		C2H2 Zn finger	191..211	CDD:275368
		C2H2 Zn finger	219..239	CDD:275368
		COG5048	243..621	CDD:227381	39/206 (19%)
		C2H2 Zn finger	247..267	CDD:275368
		C2H2 Zn finger	275..295	CDD:275368
		C2H2 Zn finger	303..323	CDD:275368
		C2H2 Zn finger	331..351	CDD:275368
		C2H2 Zn finger	359..379	CDD:275368
		C2H2 Zn finger	387..407	CDD:275368
		C2H2 Zn finger	415..435	CDD:275368
		C2H2 Zn finger	443..463	CDD:275368
		C2H2 Zn finger	471..491	CDD:275368	4/22 (18%)
		C2H2 Zn finger	499..519	CDD:275368	3/19 (16%)
		C2H2 Zn finger	527..547	CDD:275368	5/41 (12%)
		COG5048	551..>863	CDD:227381	87/359 (24%)
		C2H2 Zn finger	555..575	CDD:275368	3/25 (12%)
		C2H2 Zn finger	583..603	CDD:275368	4/19 (21%)
		C2H2 Zn finger	611..631	CDD:275368	5/19 (26%)
		C2H2 Zn finger	639..659	CDD:275368	3/19 (16%)
		C2H2 Zn finger	699..715	CDD:275368	5/15 (33%)
		C2H2 Zn finger	723..743	CDD:275368	5/19 (26%)
		C2H2 Zn finger	751..771	CDD:275368	7/19 (37%)
		C2H2 Zn finger	779..799	CDD:275368	7/21 (33%)
		C2H2 Zn finger	807..827	CDD:275368	9/19 (47%)
		C2H2 Zn finger	835..855	CDD:275368	8/19 (42%)
		C2H2 Zn finger	863..883	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142202
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930