DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8944 and CG11902

DIOPT Version :9

Sequence 1:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	NP_651389.3	Gene:	CG11902 / 43070	FlyBaseID:	FBgn0028647	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	933	Identity:	177/933 - (18%)
Similarity:	299/933 - (32%)	Gaps:	312/933 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 RCIFCSEKFLYFDSFIGHMQTVHLGDQSVANTSSRLPFNLGEPMSLSG----RNGDLPNFHEIED 97
            ||..||.:|::.::...|..: |..::::|   |::..:|.: :|||.    |...:.:.|::..
  Fly   446 RCRKCSGRFMWPENLQRHACS-HREEKTIA---SQILCSLCD-ISLSSLSQLRLHLITHQHDLNG 505

  Fly    98 LTDADTALLEPQMVIKQELQD-LPCSDDDVVAG-----EEDDDEQRLNDSEADEDEAILPESDVP 156
            ::....:|.     .:....| |.||..|:...     |..|.::..|.|.....|..|.||:..
  Fly   506 ISPEYNSLF-----FRSFYPDGLNCSISDLAVRIAEDFEVQDFDRYYNASTESGQELDLFESETE 565

  Fly   157 VVSSKTRARKKVTKQRQRDMSSELLIAGDGDSSMDDYGDPDHSYMDDNSGEY---MDFAGFDGVN 218
            :...:|.....:           .|:.|:..:|:.:..........|...|.   .|:.|
  Fly   566 LSDEETSKTSHI-----------CLLCGETSNSLMNLMKHQICLHSDGVAELPCRCDYCG----- 614

  Fly   219 HSGFGTESDFLSYDEMVEESLLGRDREVTMHIKDRKMIQFLIHSYQRNPFLWDHGNAQFRDRVKR 283
             |||            |.::||.:.|.   |..::|      ||             :|..|:..
  Fly   615 -SGF------------VSKALLQQHRR---HRCEKK------HS-------------RFHCRICN 644

  Fly   284 ARFLDWIVLEFKSRFNISLAKDAITR----KWDNLRTVY---------KR-------------EC 322
            .||:.....|...:.:.:..|||..|    |.|....|:         ||             .|
  Fly   645 IRFIWESNYEKHEKTHHNKTKDAEERPTKLKCDQCEKVFIWHKDLNRHKRLHQPQSAAQFDCPHC 709

  Fly   323 NRMALEKTNISTLWYFKELHFLNEVYSYNDKMSDAVVKE-------------------------- 361
            :|....|..:.:   ..::|..|..|..|..:...|.:|
  Fly   710 HRRFHRKDGLKS---HLKVHAGNSDYINNQPVVPDVNQEMILARLSRPHGCKLIQCMICLSRHSK 771

  Fly   362 -TSYRRRFSAIWNDTSTAKLLSMVKRYQCFYNRFDPDYRSKERRGEGLHQMAIELQQLIDVTT-I 424
             :..|...|:...:.|.|:...:....:.||    ||..:...:.|....:..::|:..|:.. |
  Fly   772 ISDLRSHLSSHQYELSFAEDRDIPSASKAFY----PDLENTLEKDELAEMIMADVQREFDLDRFI 832

  Fly   425 QISKRIS-QLRFDYSKQKMERLNSERLGKKFIANY--------------LYYDQM---------- 464
            .|:.... :|..:.|:...|   ||:.......||              ||..|:
  Fly   833 SITNEAGLELNLESSETDTE---SEQEDNHSSLNYPCNLCTTVVKRKHQLYAHQLEEHKWEEAVL 894

  Fly   465 -------HFMDDDI-----------PP--FKCAHCPEIVQTLRELDLHM--------LTHQ---P 498
                   .|:::.:           |.  |:|..||...:....|.|||        |:.|   |
  Fly   895 VCSNCQTRFVNESLLDHHSRTLCHNPQKLFQCRKCPLRFRWRENLKLHMEVFHMLDELSIQDDLP 959

  Fly   499 SLGGGYYCNICSIQFHNAQEFDNHKQLHLGGVTEIKFNCELCTASFREKANYDEHLRRHN---EE 560
            .:.|...|..|:..|...::...|..:| |..:.| |.|..|...|..:||..:|:.||.   .:
  Fly   960 KVDGDLQCGKCNRSFRMQKDLTRHTLMH-GQESNI-FRCRWCARRFYRRANLLQHIARHGISVSQ 1022

  Fly   561 LFLPSLALNHSIMEGGLGDDEIGVEGE------------ESRGSGSRRKRRHAAKAT-------- 605
            |......|:..:..||....|..|...            |:..:||..........:
  Fly  1023 LPYAEAILDSYVNPGGRKKVECRVCNVSFPTIAALRLHLETMPAGSHHDYSSLQNYSITNQMGFE 1087

  Fly   606 ----DDMVDDDDRIGGGGGGGSGGGGTDIAKP-----YGCDVCR----RSFATPGHLNA------ 651
                |...||:|            ..|.|..|     |.|::|:    |.|....|..|
  Fly  1088 MDLYDSETDDED------------SRTHIKPPGAPSSYTCNMCQLRCLRKFELYQHQQAMHRMEK 1140

  Fly   652 --------------------HRIVHQDERERCYKCDYPQCNKSFVARNSLFEHLK-QHYSNEE-- 693
                                |:....:.||:.:||  .:|...|:..::|..|:. ||...|:
  Fly  1141 ISDGCDSCLFKSVCPEIISHHKRTQCENREKQFKC--TRCGYKFMWESNLLLHMDLQHVKTEDQE 1203

  Fly   694 ------------------FKCDICGKTFKSTKNLQNH-KQIH------------------DKIKR 721
                              |:|.:|.:.:.....|..| |:.|                  .:.||
  Fly  1204 LDESKEASGDEPKTEGQVFQCGLCTRKYNRKDRLTAHLKKFHGPDCKPSTAKTPNRPISPKEPKR 1268

  Fly   722 YVCQICGSAFAQAAGLYLHKRRH 744
            ::|..||.|.:.::.|.:|.|||
  Fly  1269 FLCAFCGKAVSSSSNLIIHMRRH 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510	20/110 (18%)
		MADF	379..472	CDD:214738	20/136 (15%)
		C2H2 Zn finger	476..496	CDD:275368	8/27 (30%)
		C2H2 Zn finger	506..526	CDD:275368	4/19 (21%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	636..656	CDD:275368	7/49 (14%)
		zf-C2H2_8	639..712	CDD:292531	21/123 (17%)
		C2H2 Zn finger	666..688	CDD:275368	5/22 (23%)
		zf-C2H2	694..716	CDD:278523	6/22 (27%)
		C2H2 Zn finger	696..716	CDD:275368	5/20 (25%)
		zf-H2C2_2	708..733	CDD:290200	10/43 (23%)
		C2H2 Zn finger	724..744	CDD:275368	7/19 (37%)
CG11902	NP_651389.3	zf-AD	6..83	CDD:285071
		C2H2 Zn finger	208..228	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	384..405	CDD:275368
		C2H2 Zn finger	417..437	CDD:275368
		C2H2 Zn finger	447..463	CDD:275368	4/15 (27%)
		C2H2 Zn finger	578..599	CDD:275368	3/20 (15%)
		C2H2 Zn finger	610..629	CDD:275368	9/39 (23%)
		C2H2 Zn finger	640..660	CDD:275368	4/19 (21%)
		C2H2 Zn finger	676..696	CDD:275368	4/19 (21%)
		C2H2 Zn finger	706..726	CDD:275368	3/22 (14%)
		C2H2 Zn finger	762..782	CDD:275368	2/19 (11%)
		C2H2 Zn finger	866..887	CDD:275368	3/20 (15%)
		C2H2 Zn finger	896..918	CDD:275368	1/21 (5%)
		C2H2 Zn finger	926..947	CDD:275368	7/20 (35%)
		C2H2 Zn finger	967..987	CDD:275368	4/19 (21%)
		C2H2 Zn finger	996..1016	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1044..1063	CDD:275368	1/18 (6%)
		C2H2 Zn finger	1224..1244	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1271..1291	CDD:275368	7/19 (37%)
		zf-H2C2_2	1283..1306	CDD:290200	5/9 (56%)
		COG5048	1295..>1367	CDD:227381
		C2H2 Zn finger	1299..1319	CDD:275368
		zf-H2C2_2	1311..1336	CDD:290200
		C2H2 Zn finger	1327..1347	CDD:275368
		zf-H2C2_2	1340..1364	CDD:290200
		C2H2 Zn finger	1355..1375	CDD:275368
		zf-H2C2_2	1367..1392	CDD:290200
		C2H2 Zn finger	1383..1401	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100