DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8944 and CG14655

DIOPT Version :9

Sequence 1:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	NP_649494.1	Gene:	CG14655 / 40594	FlyBaseID:	FBgn0037275	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	375	Identity:	84/375 - (22%)
Similarity:	124/375 - (33%)	Gaps:	138/375 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   473 PFKC--AHCPEIVQTLRELDLHMLTH---------------QPSLGGGY---------------- 504
            |..|  |:|.|:...|.:|.:|:.:|               ||:...|:
  Fly    33 PLACPFANCKELFLGLDKLTIHLFSHTSLMAQEGNESPANGQPASSRGFLAAAPPKRRAKRTRSK 97

  Fly   505 ---------------YCNICSIQFHNAQEFDNHKQL-HLGGVTEIK-------------FNCELC 540
                           :|:||...|.|.:..|.|.:| |.....|.|             :.|.||
  Fly    98 PVVPTPPPVRTTPPAHCDICEFSFRNTELRDMHVRLVHENAEGEPKQKEPQQKEPDQEPYKCHLC 162

  Fly   541 TASFREKANYDEHLR-----------------------------------------RHNEELFLP 564
            :.:||.|.:...||:                                         ||.|
  Fly   163 SKTFRMKGSLRIHLKVVHMMGVPCSNPNPNPNPSPTPASTTSAVTATPKLSICDRIRHTE----- 222

  Fly   565 SLALNHSIMEGGLGDDEIGVEGEESRGSGSRRKRRHAAKATDDMVDDDDRIGGGGGGGSGGGGTD 629
                     .|.||:      |..|..:.|   :.:|......|:....        .|...||.
  Fly   223 ---------PGALGN------GNNSTCTAS---QPYALSGALSMLQQSP--------SSPESGTA 261

  Fly   630 IAKPYGCDVCRRSFATPGHLNAHRIVHQDERERCYKCDYPQCNKSFVARNSLFEHLKQHYSNEEF 694
            ..|.:.||||.:||.|...|..|:.:|..|..  |.|:.  |.::|..:.|..:||..|...:..
  Fly   262 TPKLWECDVCSKSFTTKYFLKKHKRLHTGEMP--YTCEI--CARTFTFQQSYHKHLLYHSEVKPH 322

  Fly   695 KCDICGKTFKSTKNLQNHKQIHDKIKRYVCQICGSAFAQAAGLYLHKRRH 744
            .|.:||:.||....|.||::||...|.:.|::||..|.|.....:|.|.|
  Fly   323 VCGVCGRAFKELSTLHNHQRIHSGEKPFKCEVCGKCFRQRVSFLVHTRIH 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510
		MADF	379..472	CDD:214738
		C2H2 Zn finger	476..496	CDD:275368	7/21 (33%)
		C2H2 Zn finger	506..526	CDD:275368	8/20 (40%)
		C2H2 Zn finger	537..557	CDD:275368	8/60 (13%)
		C2H2 Zn finger	636..656	CDD:275368	9/19 (47%)
		zf-C2H2_8	639..712	CDD:292531	22/72 (31%)
		C2H2 Zn finger	666..688	CDD:275368	6/21 (29%)
		zf-C2H2	694..716	CDD:278523	8/21 (38%)
		C2H2 Zn finger	696..716	CDD:275368	8/19 (42%)
		zf-H2C2_2	708..733	CDD:290200	10/24 (42%)
		C2H2 Zn finger	724..744	CDD:275368	7/19 (37%)
CG14655	NP_649494.1	C2H2 Zn finger	268..288	CDD:275368	9/19 (47%)
		zf-H2C2_2	281..304	CDD:290200	7/26 (27%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		zf-H2C2_2	339..361	CDD:290200	9/21 (43%)
		C2H2 Zn finger	352..372	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..389	CDD:290200	3/9 (33%)
		C2H2 Zn finger	380..396	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100