DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8944 and Zfp52

DIOPT Version :9

Sequence 1:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	NP_001014180.1	Gene:	Zfp52 / 361487	RGDID:	1359149	Length:	755	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	106/460 - (23%)
Similarity:	168/460 - (36%)	Gaps:	110/460 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 ECNRMALEKTNISTLWYFKELHFLNEVYSYNDKMSDAVV------------KETSYRRRFSAIWN 373
            ||.......:.:|.|.....:|.:.:.|.|.:..:.:.|            :|..||.|..
  Rat   330 ECKECGKAFSELSHLKMHYRIHTVEKPYRYEECDTSSTVNSTLKNHQKIHTREKPYRYREC---- 390

  Fly   374 DTSTAKLLSMVKRYQCFYNRFDPDYRSKERRGEGLHQMAIELQQLI------------DVTTIQI 426
            |.|..| .|.::.||..:....| ||..|..........:...|.|            |.:.::|
  Rat   391 DKSITK-CSYLRTYQRVHTGMRP-YRCTECDKSFTTYSNLRQHQKIHTGEKPPNCKGSDKSFLRI 453

  Fly   427 SKRISQLRFDYSKQKMERLNS--ERLGKK-------FIANYLYYDQMHFMDDDIPPFKCAHCPEI 482
            |          |.:|.:::::  .|.|.|       :.:|...:.::|..:   .|::|..|.:.
  Rat   454 S----------SVRKHQKIHAGERRYGCKECSRSFTWFSNLRVHQRVHTGE---RPYRCKDCDKS 505

  Fly   483 VQTLRELDLHMLTH---QPSLGGGYYCNICSIQFHNAQEFDNHKQLHLGGVTEIKFNCELCTASF 544
            ..|...|.:|...|   :|     |.|..|.|.|........|:::|.|   |..:.|:.|..||
  Rat   506 FTTGSNLRVHQKIHTGEKP-----YKCKDCDISFLWISNLRTHQKIHTG---EKPYKCQECKKSF 562

  Fly   545 REKANYDEHLRRHNEELFLPSLALNHSIMEGGLGDDEIGVEGEESRGSGSRRKRRHAAKATDDMV 609
            ...:...:|.:.|..|........|.|.|                   .....|||....|.:
  Rat   563 TRCSYLRDHQKIHTGEKLYKCKDCNVSFM-------------------WISSLRRHQKIHTGE-- 606

  Fly   610 DDDDRIGGGGGGGSGGGGTDIAKPYGCDVCRRSFATPGHLNAHRIVHQDERERCYKCDYPQCNKS 674
                                  |||.|..|.:||.....|..|:.:|..|:.  |||  ..|:.|
  Rat   607 ----------------------KPYKCRECEKSFTQCSTLRDHQKIHTGEKP--YKC--KDCDIS 645

  Fly   675 FVARNSLFEHLKQHYSNEEFKCDICGKTFKSTKNLQNHKQIHDKIKRYVCQICGSAFAQAAGLYL 739
            |:..:||..|.|.|...:.:||.:||.:|....||:.|::||...|.|.||.|..:|.:.:.|.:
  Rat   646 FLWISSLRRHQKIHTGEKPYKCKVCGISFLWISNLKTHQKIHTGEKPYKCQECNKSFTRCSYLRV 710

  Fly   740 HKRRH 744
            |::.|
  Rat   711 HQKTH 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510	5/22 (23%)
		MADF	379..472	CDD:214738	20/113 (18%)
		C2H2 Zn finger	476..496	CDD:275368	5/19 (26%)
		C2H2 Zn finger	506..526	CDD:275368	5/19 (26%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	636..656	CDD:275368	6/19 (32%)
		zf-C2H2_8	639..712	CDD:292531	25/72 (35%)
		C2H2 Zn finger	666..688	CDD:275368	8/21 (38%)
		zf-C2H2	694..716	CDD:278523	8/21 (38%)
		C2H2 Zn finger	696..716	CDD:275368	7/19 (37%)
		zf-H2C2_2	708..733	CDD:290200	11/24 (46%)
		C2H2 Zn finger	724..744	CDD:275368	6/19 (32%)
Zfp52	NP_001014180.1	KRAB	44..84	CDD:396083
		C2H2 Zn finger	219..239	CDD:275368
		SFP1	<241..324	CDD:227516
		C2H2 Zn finger	247..295	CDD:275368
		C2H2 Zn finger	303..323	CDD:275368
		COG5048	329..702	CDD:227381	102/445 (23%)
		C2H2 Zn finger	331..351	CDD:275368	3/19 (16%)
		C2H2 Zn finger	359..379	CDD:275368	2/19 (11%)
		C2H2 Zn finger	388..407	CDD:275368	7/23 (30%)
		C2H2 Zn finger	415..435	CDD:275368	2/19 (11%)
		C2H2 Zn finger	443..463	CDD:275370	5/29 (17%)
		C2H2 Zn finger	471..491	CDD:275368	2/19 (11%)
		C2H2 Zn finger	499..519	CDD:275368	5/19 (26%)
		C2H2 Zn finger	527..547	CDD:275368	5/19 (26%)
		C2H2 Zn finger	555..575	CDD:275368	5/19 (26%)
		C2H2 Zn finger	583..603	CDD:275368	6/38 (16%)
		C2H2 Zn finger	611..631	CDD:275368	6/19 (32%)
		C2H2 Zn finger	639..659	CDD:275368	8/21 (38%)
		C2H2 Zn finger	667..687	CDD:275368	7/19 (37%)
		C2H2 Zn finger	695..715	CDD:275368	6/19 (32%)
		zf-H2C2_2	707..730	CDD:404364	3/9 (33%)
		C2H2 Zn finger	723..743	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000