DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8944 and ZNF181

DIOPT Version :10

Sequence 1:NP_573065.1 Gene:CG8944 / 32517 FlyBaseID:FBgn0030680 Length:762 Species:Drosophila melanogaster
Sequence 2:NP_001025168.2 Gene:ZNF181 / 339318 HGNCID:12971 Length:571 Species:Homo sapiens


Alignment Length:596 Identity:127/596 - (21%)
Similarity:204/596 - (34%) Gaps:196/596 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   288 DWIVLEFKSRFNISLAKDAITRKWDNLRTVYKRECNRMALEKTNISTL----------------- 335
            :|..|....|   .|.||.:.:.::||.:|     ..:::.|..:.||                 
Human    17 EWGWLSSAQR---DLYKDVMVQNYENLVSV-----AGLSVTKPYVITLLEDGKEPWMMEKKLSKG 73

  Fly   336 --------WYFKELHFLNEVYSYNDKMSDAVVKETSYRRRFS----------------------- 369
                    |..|||....:.|..:...:..:.|.......||                       
Human    74 MIPDWESRWENKELSTKKDNYDEDSPQTVIIEKVVKQSYEFSNSKKNLEYIEKLEGKHGSQVDHF 138

  Fly   370 --AIWNDTSTAKLLSMVKRYQCFYNRFDPDYRSKERRGE--------GLHQMAIELQQLIDVTTI 424
              ||.....:....|:.|     ||.|...:.||....|        ..|:..|..:.|...:.|
Human   139 RPAILTSRESPTADSVYK-----YNIFRSTFHSKSTLSEPQKISAEGNSHKYDILKKNLPKKSVI 198

  Fly   425 Q----------ISKRISQLRFDYSKQKM--ERLNSERL----------GKKFIANYLYYDQMHFM 467
            :          ::...|...|...|...  :..|.|::          ||:.|.|..:  ::|..
Human   199 KNEKVNGGKKLLNSNKSGAAFSQGKSLTLPQTCNREKIYTCSECGKAFGKQSILNRHW--RIHTG 261

  Fly   468 DDDIPPFKCAHCPEIVQTLRELDLHMLTH---QPSLGGGYYCNICSIQFHNAQEFDNHKQLHLGG 529
            :   .|::|..|.:.......|..|:::|   :|     |.|..|...|.:.....||:..|.| 
Human   262 E---KPYECRECGKTFSHGSSLTRHLISHSGEKP-----YKCIECGKAFSHVSSLTNHQSTHTG- 317

  Fly   530 VTEIKFNCELCTASFREKANYDEHLRRHNEE----------LFLPSLALNHSIMEGGLGDDEI-- 582
              |..:.|..|..||...::..||||.|.:|          .|:...:|.|        ..:|  
Human   318 --EKPYECMNCGKSFSRVSHLIEHLRIHTQEKLYECRICGKAFIHRSSLIH--------HQKIHT 372

  Fly   583 GVEGEESRGSG---------SRRKRRHAAKATDDMVDDDDRIGGGGGGGSGGGGTDIAKPYGCDV 638
            |.:..|.|..|         :|.:|.|.                            :.|.|.|:.
Human   373 GEKPYECRECGKAFCCSSHLTRHQRIHT----------------------------MEKQYECNK 409

  Fly   639 CRRSFATPGHLNAHRIVHQDER----ERC----------------------YKCDYPQCNKSFVA 677
            |.:.|::...|..|:.:|.:|:    ::|                      |:|..  |.|:|..
Human   410 CLKVFSSLSFLVQHQSIHTEEKPFECQKCRKSFNQLESLNMHLRNHIRLKPYECSI--CGKAFSH 472

  Fly   678 RNSLFEHLKQHYSNEEFKCDICGKTFKSTKNLQNHKQIHDKIKRYVCQICGSAFAQAAGLYLHKR 742
            |:||.:|.:.|...:.::|..|||||..:.||..|::||...|.|.|..||.||::.:.|..|:|
Human   473 RSSLLQHHRIHTGEKPYECIKCGKTFSCSSNLTVHQRIHTGEKPYKCNECGKAFSKGSNLTAHQR 537

  Fly   743 RHN--RPNGAV 751
            .||  :||..|
Human   538 VHNGEKPNSVV 548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8944NP_573065.1 MADF_DNA_bdg 259..344 CDD:463144 16/80 (20%)
MADF 379..472 CDD:214738 22/122 (18%)
C2H2 Zn finger 476..496 CDD:275368 4/19 (21%)
C2H2 Zn finger 506..526 CDD:275368 5/19 (26%)
C2H2 Zn finger 537..557 CDD:275368 8/19 (42%)
C2H2 Zn finger 636..656 CDD:275368 5/19 (26%)
COG5048 <666..734 CDD:227381 27/67 (40%)
C2H2 Zn finger 666..688 CDD:275368 8/21 (38%)
C2H2 Zn finger 696..716 CDD:275368 9/19 (47%)
C2H2 Zn finger 724..744 CDD:275368 8/19 (42%)
ZNF181NP_001025168.2 KRAB 4..65 CDD:214630 12/55 (22%)
COG5048 211..>539 CDD:227381 88/378 (23%)
C2H2 Zn finger 239..259 CDD:275368 4/21 (19%)
C2H2 Zn finger 267..287 CDD:275368 4/19 (21%)
C2H2 Zn finger 295..315 CDD:275368 5/19 (26%)
C2H2 Zn finger 323..343 CDD:275368 8/19 (42%)
C2H2 Zn finger 351..371 CDD:275368 3/27 (11%)
C2H2 Zn finger 379..399 CDD:275368 4/19 (21%)
C2H2 Zn finger 407..427 CDD:275368 5/19 (26%)
C2H2 Zn finger 435..455 CDD:275368 1/19 (5%)
C2H2 Zn finger 463..483 CDD:275368 8/21 (38%)
C2H2 Zn finger 491..511 CDD:275368 9/19 (47%)
C2H2 Zn finger 519..539 CDD:275368 8/19 (42%)

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