DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8944 and CG17612

DIOPT Version :9

Sequence 1:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	NP_608824.1	Gene:	CG17612 / 33639	FlyBaseID:	FBgn0031597	Length:	618	Species:	Drosophila melanogaster

Alignment Length:	792	Identity:	138/792 - (17%)
Similarity:	242/792 - (30%)	Gaps:	334/792 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 CIFCSEKFLYFDSFIGHMQTVHLGDQSVANTSSRLPFNLGEPMSLSGRNG--DLPNFHEIEDLTD 100
            |:.|    |:.|:|    .|.|.|.:.....:.::...    ||::|.:|  :.|.:.|::.:..
  Fly    27 CLQC----LHMDTF----GTKHKGPRPETQINDKVHLE----MSINGEDGLPEHPLYPEVQLVVK 79

  Fly   101 ADTALLEPQM----------------VIKQELQDLPCSDDDVVAGEED-DDEQRLNDSEADEDEA 148
            .:.||::.::                ::..|:.:...:::||:..::. .:|..|.|..|:.|..
  Fly    80 EEDALIKKKVIEENHIHNEEIIGASNIVDVEVHENHRANNDVILIQDSFAEEVILEDHPANNDVI 144

  Fly   149 ILPES----DVPVVSSKTRARKKVTKQRQRDMSSELLIAGDGDSSMDDYGDPDHSYMDDNSGEYM 209
            |:.:|    ::||:                   .|..|.|                 :|..|||.
  Fly   145 IIQDSVAEEELPVI-------------------KEEAIEG-----------------EDLQGEYF 173

  Fly   210 DFAGFDGVNHSGFGTESDFLSYDEMVEESLLGRDREVTMHIKDRKMIQFLIHSYQRNPFLWDHGN 274
            ...                    |.:||..:|..|
  Fly   174 IIT--------------------ECLEEPAIGSCR------------------------------ 188

  Fly   275 AQFRDRVKRARFLDWIVLEFKSRFNISLAKDAITRKWDNLRTVYKRECNRMALEKTNISTLWYFK 339
                           :.||                :.|||               |||
  Fly   189 ---------------VCLE----------------QSDNL---------------TNI------- 200

  Fly   340 ELHFLNEVYSYNDKMSDAVVKETSYRRRFSAIWNDTSTAKLLSMVKRYQCFYNRFDPDYRSKERR 404
                .::.:.|...::..:.:.|.........:::......|.:||      |.|| |..|||..
  Fly   201 ----FDDAHQYGIPIATILSQYTGMPVEKGDSFSEYICVTCLDVVK------NAFD-DLESKENT 254

  Fly   405 GEGLHQMAIELQQLIDVTTIQISKRISQLRFDYS------------------KQKME---RLNSE 448
            .:...|   ..:::||:.:|.:..:    ..||.                  ..|::   |.::|
  Fly   255 IQMYRQ---PKEEIIDIDSIPVKNK----PVDYEVTGKPPHRCPQCPKIFLLAAKLQAHIRTHNE 312

  Fly   449 -------RLGKKFIANYLYYDQ--------MHFMDDD-----IPPFKCAHCPEIVQTLRELDLHM 493
                   || |..:...:|..:        :|...|:     .||::|.|||::......|::|:
  Fly   313 TRTTEPPRL-KCPMCPSIYMKRGCLEAHMWIHRASDERESELEPPYRCPHCPKLFLYSSFLEIHI 376

  Fly   494 LTHQP-----SLGGGYYCNICSIQFHNAQEFDNHKQLHLGGVTEIKFNCELCTASFREKANYDEH 553
            .||:.     |....:.|..|:..|.:.....:|.::|.|   |..|.|.||..||:|::|...|
  Fly   377 QTHEDVSQRLSRKSSHKCAQCADVFSDVSSLKDHVKIHAG---ERTFKCPLCLMSFQEESNLKSH 438

  Fly   554 LRRHNEELFLPSLALNHSIMEGGLGDDEIGVEGEESRGSGSRRKRRHAAKATDDMVDDDDRIGGG 618
            ...|..
  Fly   439 DCAHTR----------------------------------------------------------- 444

  Fly   619 GGGGSGGGGTDIAKPYGCDVCRRSFATPGHLNAH-RIVHQDERERCYKCDYPQCNKSFVARNSLF 682
                           :.|..|.:.|.:..:|:.| :..|..:..  :||  .:|.::|..||.|.
  Fly   445 ---------------FKCHKCSKFFESQNYLDFHFKKSHTTKGP--FKC--IKCQQTFQKRNGLK 490

  Fly   683 EH---------LKQHYSNEEFKCDICGKTFKSTKNLQNHKQIHDKIK----RYVCQICGSAFAQA 734
            ||         |:.....:.|.|..|.|.|....|.|.|...|.|:|    |:.|..|..::...
  Fly   491 EHISSQVCVQFLRSKSPGQIFPCPKCPKKFSIEDNYQMHHATHKKVKTVIERHNCTQCKKSYQNK 555

  Fly   735 AGLYLHKRRHNR 746
            ..|..|...|||
  Fly   556 KLLTKHILSHNR 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510	8/84 (10%)
		MADF	379..472	CDD:214738	25/133 (19%)
		C2H2 Zn finger	476..496	CDD:275368	6/19 (32%)
		C2H2 Zn finger	506..526	CDD:275368	4/19 (21%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	636..656	CDD:275368	5/20 (25%)
		zf-C2H2_8	639..712	CDD:292531	22/82 (27%)
		C2H2 Zn finger	666..688	CDD:275368	9/30 (30%)
		zf-C2H2	694..716	CDD:278523	8/21 (38%)
		C2H2 Zn finger	696..716	CDD:275368	7/19 (37%)
		zf-H2C2_2	708..733	CDD:290200	9/28 (32%)
		C2H2 Zn finger	724..744	CDD:275368	4/19 (21%)
CG17612	NP_608824.1	zf-AD	187..>246	CDD:285071	15/151 (10%)
		C2H2 Zn finger	290..310	CDD:275368	2/19 (11%)
		C2H2 Zn finger	323..343	CDD:275370	1/19 (5%)
		zf-C2H2_8	356..438	CDD:292531	25/84 (30%)
		C2H2 Zn finger	359..379	CDD:275368	6/19 (32%)
		C2H2 Zn finger	394..414	CDD:275368	4/19 (21%)
		C2H2 Zn finger	422..438	CDD:275368	7/15 (47%)
		C2H2 Zn finger	447..463	CDD:275368	4/15 (27%)
		C2H2 Zn finger	476..505	CDD:275368	9/30 (30%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		C2H2 Zn finger	545..565	CDD:275368	4/19 (21%)
		C2H2 Zn finger	568..584	CDD:275368	138/792 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100