DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8944 and CG3407

DIOPT Version :9

Sequence 1:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	NP_608809.1	Gene:	CG3407 / 33606	FlyBaseID:	FBgn0031573	Length:	714	Species:	Drosophila melanogaster

Alignment Length:	731	Identity:	129/731 - (17%)
Similarity:	243/731 - (33%)	Gaps:	270/731 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SGRNGDLPNFHEIEDLTDADTALLEPQMVIKQELQDLPCSDDDVVAGEEDDDE--QRLNDSEADE 145
            |..|..:|  |:::.........:||.:.|            ||..|..:|::  ...|::....
  Fly    77 SPENDVVP--HQVDAQPTFPALAIEPTVPI------------DVSTGLHEDEDLLYAHNNASCTN 127

  Fly   146 DEAILPESDVPVVSSKTRARKKVTKQRQRDMSSELLIAGDGDSSMDDYGDPDHSYMDD---NSGE 207
            ...:||.            :|:::::.:.::..||              |..|.::.|   :|..
  Fly   128 ARKVLPH------------KKRISRKLKGNIDPEL--------------DHQHKHVQDVAPSSLY 166

  Fly   208 YMDFAGFDGVNHSGFGTESDFLSYDEMVEESLLGRDREVTMHIKDRKMIQFLIHSYQRNPFLWDH 272
            ..:..|:      ...|:.||.::        |.:..|.|: ::.|.::|.....:|:...| |.
  Fly   167 SCEICGY------AVHTQLDFFAH--------LKQHYEPTV-LEQRLVVQDPQQQHQQKEPL-DM 215

  Fly   273 GNAQFRDRVKRAR------FLDWIVLEFKSRFNISLAKDAITRKWDNLRTVYKRECNRMALEKTN 331
            .....:|::::.:      |.| :.|.|::..|||
  Fly   216 CGLSAQDKLQQEQAKLDQVFQD-VQLNFENFHNIS------------------------------ 249

  Fly   332 ISTLWYFKELHFLNEVYSY----------NDKMSDAVVKETSYRRRFSAIWNDTSTAKLLSMVKR 386
                      |.:|:|.:.          .||::..||             |.:||...:.:|.
  Fly   250 ----------HHVNDVANVGVNMVLHGQATDKLNAVVV-------------NTSSTPNSVPVVD- 290

  Fly   387 YQCFYNRFDPDYRSKERRGEGLH----QMAIE--LQQLIDVTTIQISKRISQLRFDYSKQKMERL 445
                    |.::...|...||:.    :::||  ..:|:|:                      .|
  Fly   291 --------DVEFSDTEDMLEGIRNVVDKVSIEDTCDELVDL----------------------EL 325

  Fly   446 NSERLGKKFIANYLYYDQMHFMDDDIPPFKCAHCPEIVQTLRELDLHMLTHQPSLGGGYYCNICS 510
            .|..:...:..|       :|.|...|.......|....:  |....:|...|.:|.
  Fly   326 TSSGMTAPWFNN-------NFRDITFPALLLPGEPPPASS--EPATPLLKENPHVGD-------- 373

  Fly   511 IQFHNAQEFDNHKQLHLGGVTEIKFNCELCTASFREKANYDEHLRR---HNEELFL--------- 563
               |.|.:|.:.::                 |..:|:|..::.|.:   .||:..|
  Fly   374 ---HMALDFLSPEK-----------------ADPQEEAKLEKTLSKACEPNEQTLLVAPPACQTP 418

  Fly   564 --PSLALNHSIMEGGLGDDEIGVEGEESRGSGSRRKRRHAAKATDDM-VDDDDRIGGGGGGGSGG 625
              |::...:|.:|                     :.||...:.::.. :::||............
  Fly   419 PIPTVPPANSSIE---------------------QLRRSPLELSEAFKLEEDDMTDSRPASSFEE 462

  Fly   626 GGTDIAKP------------------------YGCDVCRRSFATPGHLNAHRIVHQDERERCYKC 666
            |..|..:|                        :.||.|.|.|.:...|..|:..|  .:||.:||
  Fly   463 GDPDAEEPNECFQMEVLDTSLTEEAENKTRRKHFCDKCNRDFNSYNALKYHQYTH--NQERSHKC 525

  Fly   667 DYPQCNKSFVARNSLFEHLKQHYSNEEFKCDICGKTFKSTKNLQNH-KQIHDKIKRYVCQICGSA 730
            |  .|.:||..:::|..|.:.|...:.||||.|...|:...:|:.| ...|..:|.::|:.||.:
  Fly   526 D--SCERSFYTQSALKAHERTHSGVKPFKCDKCEFQFRQWGDLKYHIISRHSDVKAHMCEFCGKS 588

  Fly   731 FAQAAGLYLHKRRHNR 746
            |::...|.:|:|.|.|
  Fly   589 FSRRYSLVVHRRIHTR 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510	12/90 (13%)
		MADF	379..472	CDD:214738	14/98 (14%)
		C2H2 Zn finger	476..496	CDD:275368	3/19 (16%)
		C2H2 Zn finger	506..526	CDD:275368	3/19 (16%)
		C2H2 Zn finger	537..557	CDD:275368	4/22 (18%)
		C2H2 Zn finger	636..656	CDD:275368	7/19 (37%)
		zf-C2H2_8	639..712	CDD:292531	24/72 (33%)
		C2H2 Zn finger	666..688	CDD:275368	7/21 (33%)
		zf-C2H2	694..716	CDD:278523	8/22 (36%)
		C2H2 Zn finger	696..716	CDD:275368	6/20 (30%)
		zf-H2C2_2	708..733	CDD:290200	8/25 (32%)
		C2H2 Zn finger	724..744	CDD:275368	7/19 (37%)
CG3407	NP_608809.1	COG5048	<494..656	CDD:227381	38/115 (33%)
		C2H2 Zn finger	497..517	CDD:275368	7/19 (37%)
		zf-H2C2_2	509..534	CDD:290200	11/28 (39%)
		C2H2 Zn finger	525..545	CDD:275368	7/21 (33%)
		zf-H2C2_2	537..562	CDD:290200	9/24 (38%)
		C2H2 Zn finger	555..574	CDD:275371	4/18 (22%)
		zf-C2H2	580..602	CDD:278523	7/21 (33%)
		C2H2 Zn finger	582..602	CDD:275368	7/19 (37%)
		zf-H2C2_2	594..617	CDD:290200	5/11 (45%)
		C2H2 Zn finger	610..630	CDD:275368
		zf-H2C2_2	622..645	CDD:290200
		zf-C2H2	636..658	CDD:278523
		C2H2 Zn finger	638..658	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010