DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8944 and CG11696

DIOPT Version :9

Sequence 1:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster

Alignment Length:	742	Identity:	152/742 - (20%)
Similarity:	244/742 - (32%)	Gaps:	293/742 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 DLPNFHEIEDLTDADTAL--------LEPQMVIK-QELQD-LPCSD--DDVVAGEEDDDEQRLN- 139
            :||   |:.:||:.:.||        :||::..: .:::| :.|..  |.:.||:|.|.:....
  Fly    87 ELP---ELPELTEPEPALVVWNTESPIEPKLSYEGDDIKDHILCEPVIDALSAGDEKDSDYGDTF 148

  Fly   140 ------DSEADEDEAILPESDVP----------------VVSSKTRARK-----KVT-------K 170
                  :|:.||:|...|:...|                ::..|...||     |:|       :
  Fly   149 EPDFEPESQPDEEEEPEPDPVKPRPRGRPRKTALQQTHQIIKRKYEKRKQQNKAKITELSLRESR 213

  Fly   171 QRQRDMSSELLIAGDGDSSMDDYGDPDHSYMDDNSGEYMDFAGFDGVNHSGFGTESDFLSYDEMV 235
            .|||::......|.|     |..||.|....:|..||
  Fly   214 ARQRELKRSSAGAED-----DQDGDEDEEDEEDVGGE---------------------------- 245

  Fly   236 EESLLGRDREVTMHIKDRKMIQFLIHSYQRNPFLWDHGNAQFRDRVKRARFLDWIVLEFKSRFNI 300
                                             |....:.|.:.|.||.|
  Fly   246 ---------------------------------LTPDADEQPKPRGKRGR--------------- 262

  Fly   301 SLAKDAITRKWDNLRTVYKRECNRMALEKTNISTLWYFKELHFLNEVYSYNDKMSDAVVKE---- 361
            ...|..:|.. ||      .:.:.:.:::::|      ||   :::..:.|.|:..|:...
  Fly   263 PKTKKLVTAD-DN------DDTSEVPVKRSSI------KE---MDDYIAANVKLDCAICAAPLED 311

  Fly   362 -TSYRRRFSAIWNDTSTAKLLSMVKRYQCFYNRF--------------DPDYRSKE--------R 403
             ...:|.|....:.|...|         |..||:              ||.|.|.:        |
  Fly   312 FNDLKRHFRVEHDCTGYVK---------CCNNRYKKRTLYVDHLHCHKDPQYFSCQSCRKNFLNR 367

  Fly   404 RGEGLHQMAIELQQLIDVTTIQISKRISQLRFDYSKQKMER---LNSERLGKKFIANYLYYDQMH 465
            ..:.:|                      .|||...:|::..   :...|..|||:..      ||
  Fly   368 NSQVMH----------------------MLRFHSQQQELVHQCAICEARFAKKFLLT------MH 404

  Fly   466 FMDDDIPPFKCAHCPEIVQTLRELDLHMLTHQPSLGGGYYCNICSIQFHNAQEFDNH-KQLHLGG 529
                                   |..|..|.:|.:     |:.||..|....|...| |::|...
  Fly   405 -----------------------LKGHKGTERPEV-----CDTCSKTFRTKFELSAHVKRMHAAD 441

  Fly   530 VTEIKFNCELCTASFREKANYDEHLRRHNEELFLPSLALNHSIMEGGLGDDEIGVEGEESRGSGS 594
            .|.|  .|::|...||.|||:..|.:           ||:   .:|.:.:.:..:.|...|...|
  Fly   442 FTPI--ICDICGTHFRSKANFLIHKK-----------ALH---PDGPVAEVQCTLCGRWLRDERS 490

  Fly   595 RRKRRHAAKATDDMVDDDDRIGGGGGGGSGGGGTDIAKPYGCDVCRRSFATPGHLNAH-RIVHQD 658
            .||  |.|:       .|||.|.              ..|.|.:|....::...|::| |..|..
  Fly   491 LRK--HLAR-------HDDRDGD--------------TKYRCLLCNAEKSSRAALSSHMRYHHSA 532

  Fly   659 ERERCYKCDYPQCNKSFVARNSLFEHLKQHYSNEEFKCDICGKTFKSTKNLQNH-KQIH--DKIK 720
            :|.:|..||     |.|....:|.||:..|...:.::|..|.:||||..|:.|| |::|  |.::
  Fly   533 KRHKCSLCD-----KEFKLPRALAEHMATHTGIDLYQCQFCTRTFKSHANMHNHKKKMHPNDWVR 592

  Fly   721 RYVCQICGSAFAQAAGLYLHKRRHNRP 747
            :| .|...|..:.||.| .|....|:|
  Fly   593 KY-SQPSSSITSTAAPL-AHPNHPNQP 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510	13/84 (15%)
		MADF	379..472	CDD:214738	20/117 (17%)
		C2H2 Zn finger	476..496	CDD:275368	2/19 (11%)
		C2H2 Zn finger	506..526	CDD:275368	7/20 (35%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	636..656	CDD:275368	5/20 (25%)
		zf-C2H2_8	639..712	CDD:292531	22/73 (30%)
		C2H2 Zn finger	666..688	CDD:275368	7/21 (33%)
		zf-C2H2	694..716	CDD:278523	10/22 (45%)
		C2H2 Zn finger	696..716	CDD:275368	10/20 (50%)
		zf-H2C2_2	708..733	CDD:290200	9/27 (33%)
		C2H2 Zn finger	724..744	CDD:275368	6/19 (32%)
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071
		C2H2 Zn finger	332..349	CDD:275368	2/16 (13%)
		C2H2 Zn finger	357..378	CDD:275368	4/42 (10%)
		C2H2 Zn finger	388..408	CDD:275368	7/48 (15%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	447..465	CDD:275368	8/17 (47%)
		C2H2 Zn finger	478..498	CDD:275368	7/28 (25%)
		C2H2 Zn finger	509..529	CDD:275368	5/19 (26%)
		C2H2 Zn finger	537..557	CDD:275368	8/24 (33%)
		C2H2 Zn finger	565..583	CDD:275368	9/17 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100