DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8944 and Zfp160

DIOPT Version :9

Sequence 1:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	NP_663458.2	Gene:	Zfp160 / 224585	MGIID:	108187	Length:	650	Species:	Mus musculus

Alignment Length:	471	Identity:	105/471 - (22%)
Similarity:	170/471 - (36%)	Gaps:	133/471 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 RECNRMALEKTNISTLWYFKELHFLNEVYSYNDKMSDAVVKETSYRRRFSAIWNDTSTAKLLSMV 384
            :||:::.   :..|:|.|.:::|...::|...:      ..:..:||.:..:.....|.     .
Mouse   149 KECDKVF---SYTSSLAYHRQIHTGEKLYKCLE------CGKAFFRRSYLLVHERHHTG-----A 199

  Fly   385 KRYQCFYNRFDPDYRSKERRGEGLHQMAIELQQLIDVTTIQISKRISQLRFDYSKQKMERLNSER 449
            |.|:|            ...|:...|                :..:...|..::.:|..:.|  .
Mouse   200 KPYKC------------NECGKVFSQ----------------NSHLKSHRRIHTGEKPFKCN--H 234

  Fly   450 LGKKFI--ANYLYYDQMHFMDDDIPPFKCAHCPEIVQTLRELDLHMLTH---QPSLGGGYYCNIC 509
            .||.|.  :|..::..:|..|   .|:||..|.::......|.:|..||   :|     |.||.|
Mouse   235 CGKAFSVRSNLTHHQVIHTGD---KPYKCNECGKVFSQTSSLTIHRRTHTGEKP-----YRCNEC 291

  Fly   510 SIQFHNAQEFDNHKQLHLGGVTEIKFNCELCTASFREKANYDEHLRRHNEE------------LF 562
            ...|.:....:.|:.:|.|   |..:.|..|...|.:.::...|.|.|..|            ..
Mouse   292 GKVFSSHSNLNTHQAIHTG---EKPYKCSECGKVFTQNSHLANHWRIHTGEKPYKCNECGKAFSV 353

  Fly   563 LPSLALNHSIMEG-----------------------GLGDDEIGVEGEE-----SRGSG-SRRKR 598
            ..||..:.:|..|                       |:...|...:.||     |:.|. :|..|
Mouse   354 YSSLTTHQAIHTGEKPYKCNECGKVFTQNSHLASHRGVHSGEKPYKCEECGKLFSQTSNLARHWR 418

  Fly   599 RHAAKATDDMVDDDDRIGGGGGGGSGGGGTDIAKPYGCDVCRRSFATPGHLNAHRIVHQDERERC 663
            .|..:                            |||.|..|.::|:....|.||:::|..|:.
Mouse   419 VHTGE----------------------------KPYKCSECGKAFSVRSSLIAHQVIHTGEKP-- 453

  Fly   664 YKCDYPQCNKSFVARNSLFEHLKQHYSNEEFKCDICGKTFKSTKNLQNHKQIHDKIKRYVCQICG 728
            |||  .:|.|.|...:||..|.:.|...:.::|:.|||.|.|..||..|:.||...|.|.|..||
Mouse   454 YKC--TECGKVFSQTSSLSIHQRIHTGEKPYRCNECGKAFNSHSNLNTHQVIHTGQKPYKCMQCG 516

  Fly   729 SAFAQAAGLYLHKRRH 744
            ..|.|.:.|..|:|.|
Mouse   517 KVFTQNSHLANHQRTH 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510	6/23 (26%)
		MADF	379..472	CDD:214738	14/94 (15%)
		C2H2 Zn finger	476..496	CDD:275368	4/19 (21%)
		C2H2 Zn finger	506..526	CDD:275368	5/19 (26%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	636..656	CDD:275368	6/19 (32%)
		zf-C2H2_8	639..712	CDD:292531	25/72 (35%)
		C2H2 Zn finger	666..688	CDD:275368	7/21 (33%)
		zf-C2H2	694..716	CDD:278523	9/21 (43%)
		C2H2 Zn finger	696..716	CDD:275368	9/19 (47%)
		zf-H2C2_2	708..733	CDD:290200	11/24 (46%)
		C2H2 Zn finger	724..744	CDD:275368	8/19 (42%)
Zfp160	NP_663458.2	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	148..168	CDD:275368	5/21 (24%)
		C2H2 Zn finger	176..196	CDD:275368	2/25 (8%)
		zf-H2C2_2	188..213	CDD:290200	5/41 (12%)
		COG5048	200..635	CDD:227381	95/406 (23%)
		zf-C2H2	202..224	CDD:278523	5/49 (10%)
		C2H2 Zn finger	204..224	CDD:275368	4/47 (9%)
		zf-H2C2_2	216..240	CDD:290200	5/25 (20%)
		C2H2 Zn finger	232..252	CDD:275368	5/21 (24%)
		zf-H2C2_2	244..269	CDD:290200	7/27 (26%)
		C2H2 Zn finger	260..280	CDD:275368	4/19 (21%)
		zf-H2C2_2	272..297	CDD:290200	10/29 (34%)
		C2H2 Zn finger	288..308	CDD:275368	5/19 (26%)
		zf-H2C2_2	300..325	CDD:290200	7/27 (26%)
		C2H2 Zn finger	316..336	CDD:275368	5/19 (26%)
		C2H2 Zn finger	344..364	CDD:275368	2/19 (11%)
		zf-H2C2_2	356..381	CDD:290200	4/24 (17%)
		C2H2 Zn finger	372..392	CDD:275368	1/19 (5%)
		zf-H2C2_2	384..409	CDD:290200	4/24 (17%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		zf-H2C2_2	412..436	CDD:290200	8/51 (16%)
		C2H2 Zn finger	428..448	CDD:275368	6/19 (32%)
		zf-H2C2_2	440..465	CDD:290200	11/28 (39%)
		C2H2 Zn finger	456..476	CDD:275368	7/21 (33%)
		zf-H2C2_2	468..493	CDD:290200	9/24 (38%)
		C2H2 Zn finger	484..504	CDD:275368	9/19 (47%)
		zf-H2C2_2	496..521	CDD:290200	11/24 (46%)
		C2H2 Zn finger	512..532	CDD:275368	8/19 (42%)
		zf-H2C2_2	524..548	CDD:290200	4/9 (44%)
		C2H2 Zn finger	540..560	CDD:275368
		zf-H2C2_2	552..577	CDD:290200
		C2H2 Zn finger	568..588	CDD:275368
		zf-H2C2_2	580..604	CDD:290200
		C2H2 Zn finger	596..616	CDD:275368
		zf-H2C2_2	608..633	CDD:290200
		C2H2 Zn finger	624..644	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832278
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930