DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8944 and E4f1

DIOPT Version :9

Sequence 1:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	NP_001288713.1	Gene:	E4f1 / 13560	MGIID:	109530	Length:	783	Species:	Mus musculus

Alignment Length:	387	Identity:	79/387 - (20%)
Similarity:	116/387 - (29%)	Gaps:	127/387 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   474 FKCAHCPEIVQTLRELDLHMLTHQPSLGGGYYCNICSIQFHNAQEFDNHKQLHLGGVTEIKFNCE 538
            :.|..|.:..:|...|..||:||  |....:.|.:|...|........|.:.|   ..|..:.|.
Mouse   193 YVCMLCHKTFKTGSILKAHMVTH--SSRKDHECKLCGASFRTKGSLIRHHRRH---TDERPYKCA 252

  Fly   539 LCTASFREKANYDEHLRR------------------HNEELFLPSLALNHSIMEGGLGDD----- 580
            .|..||||......||:.                  ..||:...|.|.....:...:..|
Mouse   253 KCGKSFRESGALTRHLKSLTPCTEKIRFSISKDTAVGKEEVPAGSSASTVGTVTSSVAGDPMETS 317

  Fly   581 ---------------EIGVEGEE-------------------SRGSGSRRKRRHAAKATDDMVDD 611
                           |:.|:.:|                   .....||....|.|.....:|
Mouse   318 PVIHLVTDAKGTVIHEVHVQMQELPLGMKALTPESPDSEELPCSSENSRENLLHQAMQNSGIV-- 380

  Fly   612 DDRIGG-----------GG-----GGGS---------------GGGGTDIAKPYGCDVCRRSFAT 645
            .:|:.|           |.     |.||               ......:.:.:.|..|..:|.|
Mouse   381 LERVAGEESALEPAPPSGSSPQCLGDGSPELPLLKVEQIETQVASEAATVPRTHPCPQCSETFPT 445

  Fly   646 PGHLNAHRIVHQDERERCYKCDYPQCNKSFVARNSLFEHLKQHYSNEEFKCDICGKTFKSTKNLQ 710
            ...|.||:..|...|.  :.|  .||.|:|.....|.:|.:.|.....|:|..|||.:|:..:::
Mouse   446 AATLEAHKRGHIAPRP--FTC--TQCGKAFPKAYLLKKHQEVHVHERRFRCGDCGKLYKTIAHVR 506

  Fly   711 NHKQIHDKI---------KRY-------------------VCQICGSAFAQAAGLYLHKRRH 744
            .|:::|...         |||                   |||.|...|.:...|..|.|.|
Mouse   507 GHRRVHSDERPFPCPQCGKRYKTKNAQQVHFRTHLEEKPHVCQFCSRGFREKGSLVRHVRHH 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510
		MADF	379..472	CDD:214738
		C2H2 Zn finger	476..496	CDD:275368	6/19 (32%)
		C2H2 Zn finger	506..526	CDD:275368	4/19 (21%)
		C2H2 Zn finger	537..557	CDD:275368	8/37 (22%)
		C2H2 Zn finger	636..656	CDD:275368	7/19 (37%)
		zf-C2H2_8	639..712	CDD:292531	22/72 (31%)
		C2H2 Zn finger	666..688	CDD:275368	7/21 (33%)
		zf-C2H2	694..716	CDD:278523	7/21 (33%)
		C2H2 Zn finger	696..716	CDD:275368	6/19 (32%)
		zf-H2C2_2	708..733	CDD:290200	10/52 (19%)
		C2H2 Zn finger	724..744	CDD:275368	7/19 (37%)
E4f1	NP_001288713.1	Required for ubiquitin ligase activity. /evidence=ECO:0000250	40..84
		Mediates dimerization, DNA-binding, transcription repression of CCNA2 and interaction with HMGA2. /evidence=ECO:0000250	185..264		21/75 (28%)
		COG5048	193..594	CDD:227381	79/387 (20%)
		C2H2 Zn finger	195..215	CDD:275368	6/19 (32%)
		zf-C2H2	221..243	CDD:278523	4/21 (19%)
		C2H2 Zn finger	223..243	CDD:275368	4/19 (21%)
		zf-H2C2_2	235..258	CDD:290200	5/25 (20%)
		C2H2 Zn finger	251..269	CDD:275368	7/17 (41%)
		Mediates interaction with CDKN2A. /evidence=ECO:0000250	368..565		43/202 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..407		3/20 (15%)
		Interaction with BMI1. /evidence=ECO:0000250	434..598		37/139 (27%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		zf-C2H2	462..484	CDD:278523	7/23 (30%)
		C2H2 Zn finger	464..484	CDD:275368	7/21 (33%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		zf-H2C2_2	504..529	CDD:290200	5/24 (21%)
		Mediates interaction with TP53. /evidence=ECO:0000250	520..579		12/49 (24%)
		C2H2 Zn finger	520..540	CDD:275368	3/19 (16%)
		zf-H2C2_2	534..555	CDD:290200	4/20 (20%)
		C2H2 Zn finger	548..568	CDD:275368	7/19 (37%)
		zf-H2C2_2	560..584	CDD:290200	4/9 (44%)
		Mediates interaction with RASSF1. /evidence=ECO:0000250	574..596
		C2H2 Zn finger	576..595	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100