DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11679 and RMND1

DIOPT Version :9

Sequence 1:	NP_573063.1	Gene:	CG11679 / 32515	FlyBaseID:	FBgn0030678	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_060379.2	Gene:	RMND1 / 55005	HGNCID:	21176	Length:	449	Species:	Homo sapiens

Alignment Length:	372	Identity:	138/372 - (37%)
Similarity:	204/372 - (54%)	Gaps:	46/372 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 TQWMMD-RRRWLASEATSSAAAPAQAASVPRTQTQPRVK-PLPLAEERLESILSPIRTRIIRKKR 87
            ::|.:. .:|..:|.:|.:        .||: |..|:|| ||..:..|     .|.||.:   ..
Human   116 SKWFIKILKRHFSSVSTET--------FVPK-QDFPQVKRPLKASRTR-----QPSRTNL---PV 163

  Fly    88 LAIDELSALGFLNTRGYTTAEEYNLEDLQIALREQNLYETKRFFSTDNLDVEQNVLFVAAKYPTG 152
            |:::|    ..::...:.||:||:|.:|...|......|.     |.......|:|.:..:....
Human   164 LSVNE----DLMHCTAFATADEYHLGNLSQDLASHGYVEV-----TSLPRDAANILVMGVENSAK 219

  Fly   153 Q-QPREIFFFREGSVVFWNCSDIETNNVLSFLRAFERESYVSALVHGESEVMPYTYIPSTAVDVE 216
            : .|..|||||||:.||||..|....:|:..|...|.:.|..||||.|:|.:.|       :.:|
Human   220 EGDPGTIFFFREGAAVFWNVKDKTMKHVMKVLEKHEIQPYEIALVHWENEELNY-------IKIE 277

  Fly   217 GDLVAESSDFNVTSRAFFQNGKFFVTADTDSFLYKYTFSNAMAQSIKLGMWEATLDRYIDSIEHL 281
            |.......:..:.|.....          |:.|.|:.||||:..|:||.:|||:||::|:||:.:
Human   278 GQSKLHRGEIKLNSELDLD----------DAILEKFAFSNALCLSVKLAIWEASLDKFIESIQSI 332

  Fly   282 TEDLKRGRRLRISRAAMLRKTGELFALRHVINLSSDLLDAPDFYWDREELEALYLQVCSYFSISR 346
            .|.||.|:::::|...:::|.||||||||.||||||.|..||||||||.||.||.:.|.:.||.|
Human   333 PEALKAGKKVKLSHEEVMQKIGELFALRHRINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGR 397

  Fly   347 RTKVMNEKINHCVELAELVSHNLNDAHHIRLEWMIIILIMVEVGFEV 393
            |.||||||:.||:||.:|:.::||:...:||||||:|||.:||.||:
Human   398 RVKVMNEKLQHCMELTDLMRNHLNEKRALRLEWMIVILITIEVMFEL 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11679	NP_573063.1	DUF155	158..352	CDD:280704	84/193 (44%)
RMND1	NP_060379.2	DUF155	226..403	CDD:280704	84/193 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152777
Domainoid	1	1.000	166	1.000	Domainoid score	I3911
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5675
Inparanoid	1	1.050	221	1.000	Inparanoid score	I3561
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D415618at33208
OrthoFinder	1	1.000	-	-		FOG0003403
OrthoInspector	1	1.000	-	-		oto89267
orthoMCL	1	0.900	-	-		OOG6_101806
Panther	1	1.100	-	-	LDO	PTHR16255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2342
SonicParanoid	1	1.000	-	-		X2300
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.930