DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp6 and Actr2

DIOPT Version :9

Sequence 1:	NP_511165.1	Gene:	Arp6 / 32514	FlyBaseID:	FBgn0011741	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_001349828.1	Gene:	Actr2 / 66713	MGIID:	1913963	Length:	399	Species:	Mus musculus

Alignment Length:	420	Identity:	117/420 - (27%)
Similarity:	181/420 - (43%)	Gaps:	73/420 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VVVLDNGAHTAKVGLANQDEP-HVVPNCI-------------MKAKSERRR-AFVGNQIDECRDT 54
            |||.|||....|.|.|..:.| |:.|..:             ::.|:.::. ..||::..|.|..
Mouse     8 VVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKNNKKMDLMVGDEASELRSM 72

  Fly    55 SALYYILAFQRGYLLNWHTQKTVWDYIFSKDGIGCSLENRNIVITEPQMNFQSIQEATLEILFEE 119
            ..:.|  ..:.|.:.||...|.:|||.|..:.:.....|..|::|||.||....:|..:|::||.
Mouse    73 LEVNY--PMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNREKIVEVMFET 135

  Fly   120 YKVDGVYKTTAADLAAFNYVADSEERTTMESLNCIIIDVGYSFTHVVPFVLGRRVLQGIRRIDMG 184
            |:..|||....|.|..:          ....|..:::|.|...||:.|...|..:....||:|:.
Mouse   136 YQFSGVYVAIQAVLTLY----------AQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIA 190

  Fly   185 GKALTNQLKELISYR--HLNVMDESHVVNQIKEDVCFVAEDFKQAMQVHYSEEK-RREVTV---D 243
            |:.:|..|.:|:..|  ..|...:...|..|||.:|:|..:.:|       |:| ..|.||   .
Mouse   191 GRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQ-------EQKLALETTVLVES 248

  Fly   244 YVLPDFTTVKRGYVRVPGKPREDEEQQQMVSLCNERFTVPELLFNPSDIGVQQVGIPEAVADCLK 308
            |.|||...:|.|                     .|||..||.||.|..|.|:.||:.|.:.:.::
Mouse   249 YTLPDGRIIKVG---------------------GERFEAPEALFQPHLINVEGVGVAELLFNTIQ 292

  Fly   309 ACPWEAHRELLLNILIVGGSAQFPGFLPRLKRDLRALV--------PDDLEVSLICPEDPVR--- 362
            |...:...|...:|::.|||..:||...||:|:|:.|.        .:.|....|..|||.|
Mouse   293 AADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKH 357

  Fly   363 YAWYGGKEVA-TSPNFEEFVYTQDDYEEYG 391
            ..:.||..:| ...:.:.|..|:.:|:|.|
Mouse   358 MVFLGGAVLADIMKDKDNFWMTRQEYQEKG 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp6	NP_511165.1	ACTIN	3..398	CDD:214592	117/420 (28%)
Arp6	NP_511165.1	COG5277	6..391	CDD:227602	115/417 (28%)
Actr2	NP_001349828.1	ACTIN	6..393	CDD:214592	117/420 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010