DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp6 and POTEJ

DIOPT Version :9

Sequence 1:	NP_511165.1	Gene:	Arp6 / 32514	FlyBaseID:	FBgn0011741	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	XP_011509985.1	Gene:	POTEJ / 653781	HGNCID:	37094	Length:	1048	Species:	Homo sapiens

Alignment Length:	398	Identity:	105/398 - (26%)
Similarity:	186/398 - (46%)	Gaps:	47/398 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AVVVLDNGAHTAKVGLANQDEPHVV-PNCI-------MKAKSERRRAFVGNQIDECRDTSALYYI 60
            ||:|:|||:...|.|.|..|.|..| |:.:       |.....::.::||.:....|....|.|
Human   679 AVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGCPRQQGMMGGMHQKESYVGKEAQSKRGILTLKY- 742

  Fly    61 LAFQRGYLLNWHTQKTVWDYIFSKDGIGCSLENRNIVITEPQMNFQSIQEATLEILFEEYKVDGV 125
             ..:.|.:.||...:.:|.:.|..: :..:.|...|::||..:|.::.:|...:|:||.:....:
Human   743 -PMEHGIITNWDDMEKIWHHTFYNE-LRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTPAM 805

  Fly   126 YKTTAADLAAFNYVADSEERTTMESLNCIIIDVGYSFTHVVPFVLGRRVLQGIRRIDMGGKALTN 190
            |....|.|:.:     :..|||     .|::|.|...||.||...|..:.....|:|:.|:.||:
Human   806 YVAIQAMLSLY-----TSGRTT-----GIVMDSGDGVTHTVPIYDGNALPHATLRLDLAGRELTD 860

  Fly   191 QLKELISYR--HLNVMDESHVVNQIKEDVCFVAEDFKQAMQVHYSEEKRREVTVDYVLPDFTTVK 253
            .|.::::.|  ....|.|..:|..|||.:|:||.||:|.|.:..|.....:   .|.|||
Human   861 YLMKILTERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMAMVASSSSLEK---SYELPD----- 917

  Fly   254 RGYVRVPGKPREDEEQQQMVSLCNERFTVPELLFNPSDIGVQQVGIPEAVADCLKACPWEAHREL 318
                            .|::::.||.|..||.||.|..:|::..||.|...:.:.....:..::|
Human   918 ----------------GQVITISNEWFRCPEALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDL 966

  Fly   319 LLNILIVGGSAQFPGFLPRLKRDLRALVPDDLEVSLICPEDPVRYAWYGGKEVATSPNFEEFVYT 383
            ..|.::.||:..:||...|:::::.||.|..:::.:|.|.......|.||..:|:...|::...:
Human   967 YTNTVLSGGTTMYPGMAHRMQKEIAALAPSMMKIRIIAPPKRKYSVWVGGSILASLSTFQQMWIS 1031

  Fly   384 QDDYEEYG 391
            :.:|:|.|
Human  1032 KQEYDESG 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp6	NP_511165.1	ACTIN	3..398	CDD:214592	105/398 (26%)
Arp6	NP_511165.1	COG5277	6..391	CDD:227602	102/394 (26%)
POTEJ	XP_011509985.1	Ank_2	106..209	CDD:289560
		ANK	130..265	CDD:238125
		ANK repeat	137..166	CDD:293786
		ANK repeat	168..209	CDD:293786
		ANK	206..330	CDD:238125
		ANK repeat	211..242	CDD:293786
		Ank_2	216..308	CDD:289560
		ANK repeat	244..275	CDD:293786
		ANK repeat	277..308	CDD:293786
		NBD_sugar-kinase_HSP70_actin	674..1048	CDD:302596	105/398 (26%)
		ACTIN	678..1048	CDD:214592	105/398 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920