DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp6 and POTEI

DIOPT Version :9

Sequence 1:	NP_511165.1	Gene:	Arp6 / 32514	FlyBaseID:	FBgn0011741	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_001358855.1	Gene:	POTEI / 653269	HGNCID:	37093	Length:	1097	Species:	Homo sapiens

Alignment Length:	398	Identity:	105/398 - (26%)
Similarity:	188/398 - (47%)	Gaps:	47/398 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AVVVLDNGAHTAKVGLANQDEPHVV-PNCIMKAKSE-------RRRAFVGNQIDECRDTSALYYI 60
            ||:|:|||:...|.|.|..|.|..| |:.:.:.:.:       ::.::||.:....|....|.|
Human   728 AVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKY- 791

  Fly    61 LAFQRGYLLNWHTQKTVWDYIFSKDGIGCSLENRNIVITEPQMNFQSIQEATLEILFEEYKVDGV 125
             ..:.|.:.||...:.:|.:.|..: :..:.|...|::||..:|.::.:|...:|:||.:....:
Human   792 -PMEHGIITNWDDMEKIWHHTFYNE-LRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTPAM 854

  Fly   126 YKTTAADLAAFNYVADSEERTTMESLNCIIIDVGYSFTHVVPFVLGRRVLQGIRRIDMGGKALTN 190
            |....|.|:.:     :..|||     .|::|.|...||.||...|..:.....|:|:.|:.||:
Human   855 YVAIQAMLSLY-----TSGRTT-----GIVMDSGDGVTHTVPIYDGNALPHATLRLDLAGRELTD 909

  Fly   191 QLKELISYR--HLNVMDESHVVNQIKEDVCFVAEDFKQAMQVHYSEEKRREVTVDYVLPDFTTVK 253
            .|.::::.|  ....|.|..:|..|||.:|:||.||:|.|.:..|.....:   .|.|||
Human   910 YLMKILTERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMAMAASSSSLEK---SYELPD----- 966

  Fly   254 RGYVRVPGKPREDEEQQQMVSLCNERFTVPELLFNPSDIGVQQVGIPEAVADCLKACPWEAHREL 318
                            .|::::.||.|..||.||.|..:|::..||.|...:.:.....:..::|
Human   967 ----------------GQVITIGNEWFRCPEALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDL 1015

  Fly   319 LLNILIVGGSAQFPGFLPRLKRDLRALVPDDLEVSLICPEDPVRYAWYGGKEVATSPNFEEFVYT 383
            ..|.::.||:..:||...|:::::.||.|..|::.:|.|.......|.||..:|:...|::...:
Human  1016 YTNTVLSGGTTMYPGMAHRMQKEIAALAPSMLKIRIIAPPKRKYSVWVGGSILASLSTFQQMWIS 1080

  Fly   384 QDDYEEYG 391
            :.:|:|.|
Human  1081 KQEYDESG 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp6	NP_511165.1	ACTIN	3..398	CDD:214592	105/398 (26%)
Arp6	NP_511165.1	COG5277	6..391	CDD:227602	102/394 (26%)
POTEI	NP_001358855.1	Ank_2	158..>361	CDD:393464
		ANK repeat	174..203	CDD:293786
		ANK repeat	205..236	CDD:293786
		ANK repeat	238..269	CDD:293786
		ANK repeat	271..302	CDD:293786
		ANK repeat	304..335	CDD:293786
		CCDC144C	670..>723	CDD:373382
		NBD_sugar-kinase_HSP70_actin	723..1097	CDD:388382	105/398 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920