Protein Alignment Arp6 and ACTA1

DIOPT Version :10

• Sequence 1: NP_511165.1
• Gene: Arp6 / 32514
• FlyBaseID: FBgn0011741
• Length: 398
• Species: Drosophila melanogaster
• Sequence 2: NP_001091.1
• Gene: ACTA1 / 58
• HGNCID: 129
• Length: 377
• Species: Homo sapiens
• Alignment Length: 396
• Identity: 106/396 - (26%)
• Similarity: 190/396 - (47%)
• Gaps: 47/396 - (11%)

  Fly     6 VVLDNGAHTAKVGLANQDEPHVV-PNCIMKAKSE-------RRRAFVGNQIDECRDTSALYYILA 62
            :|.|||:...|.|.|..|.|..| |:.:.:.:.:       ::.::||::....|....|.|  .
Human    10 LVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKY--P 72

  Fly    63 FQRGYLLNWHTQKTVWDYIFSKDGIGCSLENRNIVITEPQMNFQSIQEATLEILFEEYKVDGVYK 127
            .:.|.:.||...:.:|.:.|..: :..:.|....::||..:|.::.:|...:|:||.:.|..:|.
Human    73 IEHGIITNWDDMEKIWHHTFYNE-LRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYV 136

  Fly   128 TTAADLAAFNYVADSEERTTMESLNCIIIDVGYSFTHVVPFVLGRRVLQGIRRIDMGGKALTNQL 192
            ...|.|:.:     :..|||     .|::|.|...||.||...|..:...|.|:|:.|:.||:.|
Human   137 AIQAVLSLY-----ASGRTT-----GIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYL 191

  Fly   193 KELISYRHLNVMD--ESHVVNQIKEDVCFVAEDFKQAMQVHYSEEKRREVTVDYVLPDFTTVKRG 255
            .::::.|..:.:.  |..:|..|||.:|:||.||:..|....|.....:   .|.|||
Human   192 MKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK---SYELPD------- 246

  Fly   256 YVRVPGKPREDEEQQQMVSLCNERFTVPELLFNPSDIGVQQVGIPEAVADCLKACPWEAHRELLL 320
                          .|::::.||||..||.||.||.||::..||.|...:.:..|..:..::|..
Human   247 --------------GQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYA 297

  Fly   321 NILIVGGSAQFPGFLPRLKRDLRALVPDDLEVSLICPEDPVRYAWYGGKEVATSPNFEEFVYTQD 385
            |.::.||:..:||...|:::::.||.|..:::.:|.|.:.....|.||..:|:...|::...|:.
Human   298 NNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQ 362

  Fly   386 DYEEYG 391
            :|:|.|
Human   363 EYDEAG 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arp6	NP_511165.1	ASKHA_NBD_Arp6	5..391	CDD:466816	105/394 (27%)
ACTA1	NP_001091.1	ASKHA_NBD_actin	8..372	CDD:466823	106/396 (27%)
		Interaction with alpha-actinin. /evidence=ECO:0000250|UniProtKB:P68135	112..125		2/12 (17%)
		Interaction with alpha-actinin. /evidence=ECO:0000250|UniProtKB:P68135	360..372		4/9 (44%)