Protein Alignment Arp6 and ACTL6B

DIOPT Version :9

• Sequence 1: NP_511165.1
• Gene: Arp6 / 32514
• FlyBaseID: FBgn0011741
• Length: 398
• Species: Drosophila melanogaster
• Sequence 2: NP_057272.1
• Gene: ACTL6B / 51412
• HGNCID: 160
• Length: 426
• Species: Homo sapiens
• Alignment Length: 434
• Identity: 91/434 - (20%)
• Similarity: 188/434 - (43%)
• Gaps: 64/434 - (14%)

  Fly     6 VVLDNGAHTAKVGLANQDEPHV-VPNCI--MKAKSERRRAFVGNQIDECR----DTSALY----- 58
            :|.|.|:.:.:.|.|.:|.|.. .|..:  :.|:........|::..:.:    ||:||:
Human    14 LVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKEKKGKIFHIDTNALHVPRDG 78

  Fly    59 --YILAFQRGYLLNWHTQKTVWDYIFSKDGIGCSLENRNIVITEPQMNFQSIQEATLEILFEEYK 121
              .:...:.|.:.:|...:.:.|:.:||. :........::::|...|.::.:|...|::||:|.
Human    79 AEVMSPLKNGMIEDWECFRAILDHTYSKH-VKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYN 142

  Fly   122 VDGVYKTTAADLAAFNYVADSEERTTMESLNCIIIDVGYSFTHVVPFVLGRRVLQGIRRIDMGGK 186
            :...:....|.|.||     :..|:|     .:::|.|.:.|..:|...|..:.|||.:..:.|.
Human   143 IPAFFLCKTAVLTAF-----ANGRST-----GLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGD 197

  Fly   187 ALTNQLKELISYRHLNVMDESHVVNQIKEDVCFVAEDFKQAMQVHY-SEEKRREVTVDY------ 244
            .::.|.:||.....::::....:.  .||.|       ::....:: .:||..:|:..:
Human   198 FISMQCRELFQEMAIDIIPPYMIA--AKEPV-------REGAPPNWKKKEKLPQVSKSWHNYMCN 253

  Fly   245 -VLPDFTTVKRGYVRVPGKPREDEEQQQMVSL------------CNERFTVPELLFNPSDI---- 292
             |:.||   :...::|...|.:::...||.::            ..||..:||.||:||::
Human   254 EVIQDF---QASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLS 315

  Fly   293 GVQQVGIPEAVADCLKACPWEAHRELLLNILIVGGSAQFPGFLPRLKRDLRALVPDDLEVSLICP 357
            |...:|:...|...:..|..:....|..::::.||:....||..||.|:|....|..:.:.||..
Human   316 GNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIAS 380

  Fly   358 EDPVR---YAWYGGKEVATSPNFEEFVYTQDDYEEYGFQGINQR 398
            ...:.   ..|.||..:|:...|::...::.:|||.|.|.:.::
Human   381 NSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERK 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arp6	NP_511165.1	ACTIN	3..398	CDD:214592	91/432 (21%)
		COG5277	6..391	CDD:227602	89/425 (21%)
ACTL6B	NP_057272.1	Actin	11..426	CDD:394979	91/434 (21%)
		Essential for mediating its function in dendritic development, may contribute to neuronal-specific targeting. /evidence=ECO:0000250|UniProtKB:Q99MR0	39..82		6/42 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010