DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp6 and POTEE

DIOPT Version :9

Sequence 1:	NP_511165.1	Gene:	Arp6 / 32514	FlyBaseID:	FBgn0011741	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_001077007.1	Gene:	POTEE / 445582	HGNCID:	33895	Length:	1075	Species:	Homo sapiens

Alignment Length:	398	Identity:	103/398 - (25%)
Similarity:	186/398 - (46%)	Gaps:	47/398 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AVVVLDNGAHTAKVGLANQDEPHVV-PNCIMKAKSE-------RRRAFVGNQIDECRDTSALYYI 60
            ||:|:|||:...|.|.|..|.|..| |:.:.:.:.:       ::.::||.:....|....|.|
Human   706 AVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKY- 769

  Fly    61 LAFQRGYLLNWHTQKTVWDYIFSKDGIGCSLENRNIVITEPQMNFQSIQEATLEILFEEYKVDGV 125
             ..:.|.:.||...:.:|.:.|..: :..:.|...|::||..:|.::.:|...:|:||.:....:
Human   770 -PMEHGIITNWDDMEKIWHHTFYNE-LRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTPAM 832

  Fly   126 YKTTAADLAAFNYVADSEERTTMESLNCIIIDVGYSFTHVVPFVLGRRVLQGIRRIDMGGKALTN 190
            |....|..:.:     :..|||     .|::|.|...||.||...|..:.....|:|:.|:.|.:
Human   833 YVAIQAVPSLY-----TSGRTT-----GIVMDSGDGVTHTVPIYEGNALPHATLRLDLAGRELPD 887

  Fly   191 QLKELISYR--HLNVMDESHVVNQIKEDVCFVAEDFKQAMQVHYSEEKRREVTVDYVLPDFTTVK 253
            .|.::::.|  ....|.|..:|..|||.:|:||.||:|.|....|.....:   .|.|||
Human   888 YLMKILTERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEK---SYELPD----- 944

  Fly   254 RGYVRVPGKPREDEEQQQMVSLCNERFTVPELLFNPSDIGVQQVGIPEAVADCLKACPWEAHREL 318
                            .|::::.||||..||.||.|..:|::..||.|...:.:.....:..::|
Human   945 ----------------GQVITIGNERFRCPEALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDL 993

  Fly   319 LLNILIVGGSAQFPGFLPRLKRDLRALVPDDLEVSLICPEDPVRYAWYGGKEVATSPNFEEFVYT 383
            ..|.::.||:..:||...|:::::.||.|..:::.:|.|.......|.||..:|:...|::...:
Human   994 YTNTVLSGGTTMYPGMAHRMQKEIAALAPSMMKIRIIAPPKRKYSVWVGGSILASLSTFQQMWIS 1058

  Fly   384 QDDYEEYG 391
            :.:|:|.|
Human  1059 KQEYDESG 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp6	NP_511165.1	ACTIN	3..398	CDD:214592	103/398 (26%)
Arp6	NP_511165.1	COG5277	6..391	CDD:227602	100/394 (25%)
POTEE	NP_001077007.1	Ank_4	143..193	CDD:290365
		ANK	167..292	CDD:238125
		ANK 1	172..201
		ANK repeat	174..203	CDD:293786
		Ank_2	177..269	CDD:289560
		ANK repeat	205..236	CDD:293786
		ANK 2	205..234
		ANK	233..357	CDD:238125
		ANK repeat	238..269	CDD:293786
		ANK 3	238..267
		Ank_2	243..335	CDD:289560
		ANK repeat	271..302	CDD:293786
		ANK 4	271..300
		ANK repeat	304..335	CDD:293786
		ANK 5	304..333
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	369..530
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	544..599
		NBD_sugar-kinase_HSP70_actin	701..1075	CDD:302596	103/398 (26%)
		Actin-like	702..1075		103/398 (26%)
		ACTIN	705..1075	CDD:214592	103/398 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920