DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp6 and ACTL9

DIOPT Version :9

Sequence 1:	NP_511165.1	Gene:	Arp6 / 32514	FlyBaseID:	FBgn0011741	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_848620.3	Gene:	ACTL9 / 284382	HGNCID:	28494	Length:	416	Species:	Homo sapiens

Alignment Length:	398	Identity:	98/398 - (24%)
Similarity:	172/398 - (43%)	Gaps:	54/398 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VVLDNGAHTAKVGLANQDEPHVVPNCIMKAKSER--------RRAFVGNQIDECRDTSALYYILA 62
            ||:|.|..|.|||.|.|..|......|:..:.::        .:.|:|   :..|....|..:..
Human    52 VVIDMGTGTCKVGFAGQASPTYTVATILGCQPKKPATSGQSGLQTFIG---EAARVLPELTLVQP 113

  Fly    63 FQRGYLLNWHTQKTVWDYIFSKDGIGCSLENRNIVITEPQMNFQSIQEATLEILFEEYKVDGVYK 127
            .:.|.:::|...:.:|.::...| :..:..:..::.::|..:..:.:|..:|:.||..:...:|.
Human   114 LRSGIVVDWDAAELIWRHLLEHD-LRVATHDHPLLFSDPPFSPATNREKLVEVAFESLRSPAMYV 177

  Fly   128 TTAADLAAFNYVADSEERTTMESLNCIIIDVGYSFTHVVPFVLGRRVLQGIRRIDMGGKALTNQL 192
            .:.:.|:.:.:          ..::.:::|.|:..|:.||...|..:|....|:|:.|..||..|
Human   178 ASQSVLSVYAH----------GRVSGLVVDTGHGVTYTVPVFQGYNLLHATERLDLAGNNLTAFL 232

  Fly   193 KELISYRHLNV-MDESHVVNQIKEDVCFVAEDFKQAMQVHYSEEKRREVTVDYVLPDFTTVKRGY 256
            .|::....|.: ..:..:|..||...|:||.|| |..|....:|.:|.:.    |||..||..|
Human   233 AEMLLQAGLPLGQQDLDLVENIKHHYCYVASDF-QKEQARPEQEYKRTLK----LPDGRTVTLG- 291

  Fly   257 VRVPGKPREDEEQQQMVSLCNERFTVPELLFNPSDI-GVQQVGIPEAVADCLKACPWEAHRELLL 320
                                .|.|..|||||||.:: |:..||:.......|:....|...:|..
Human   292 --------------------KELFQCPELLFNPPEVPGLSPVGLSTMAKQSLRKLSLEMRADLAQ 336

  Fly   321 NILIVGGSAQFPGFLPRLKRDLRALVPDDLEVSLICPEDPVR--YAWYGGKEVATSPNFEEFVYT 383
            |:|:.|||:.|.||..|.:.:|...:|  .|..::....|.|  ..|.||..:|:...|:.....
Human   337 NVLLCGGSSLFTGFEGRFRAELLRALP--AETHVVVAAQPTRNFSVWIGGSILASLRAFQSCWVL 399

  Fly   384 QDDYEEYG 391
            ::.|||.|
Human   400 REQYEEQG 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp6	NP_511165.1	ACTIN	3..398	CDD:214592	98/398 (25%)
Arp6	NP_511165.1	COG5277	6..391	CDD:227602	97/396 (24%)
ACTL9	NP_848620.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		NBD_sugar-kinase_HSP70_actin	49..416	CDD:302596	98/398 (25%)
		ACTIN	49..415	CDD:214592	98/398 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920