DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp6 and Acta1

DIOPT Version :9

Sequence 1:	NP_511165.1	Gene:	Arp6 / 32514	FlyBaseID:	FBgn0011741	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_001258970.1	Gene:	Acta1 / 11459	MGIID:	87902	Length:	377	Species:	Mus musculus

Alignment Length:	396	Identity:	106/396 - (26%)
Similarity:	190/396 - (47%)	Gaps:	47/396 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VVLDNGAHTAKVGLANQDEPHVV-PNCIMKAKSE-------RRRAFVGNQIDECRDTSALYYILA 62
            :|.|||:...|.|.|..|.|..| |:.:.:.:.:       ::.::||::....|....|.|  .
Mouse    10 LVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKY--P 72

  Fly    63 FQRGYLLNWHTQKTVWDYIFSKDGIGCSLENRNIVITEPQMNFQSIQEATLEILFEEYKVDGVYK 127
            .:.|.:.||...:.:|.:.|..: :..:.|....::||..:|.::.:|...:|:||.:.|..:|.
Mouse    73 IEHGIITNWDDMEKIWHHTFYNE-LRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYV 136

  Fly   128 TTAADLAAFNYVADSEERTTMESLNCIIIDVGYSFTHVVPFVLGRRVLQGIRRIDMGGKALTNQL 192
            ...|.|:.:     :..|||     .|::|.|...||.||...|..:...|.|:|:.|:.||:.|
Mouse   137 AIQAVLSLY-----ASGRTT-----GIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYL 191

  Fly   193 KELISYRHLNVMD--ESHVVNQIKEDVCFVAEDFKQAMQVHYSEEKRREVTVDYVLPDFTTVKRG 255
            .::::.|..:.:.  |..:|..|||.:|:||.||:..|....|.....:   .|.|||
Mouse   192 MKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK---SYELPD------- 246

  Fly   256 YVRVPGKPREDEEQQQMVSLCNERFTVPELLFNPSDIGVQQVGIPEAVADCLKACPWEAHRELLL 320
                          .|::::.||||..||.||.||.||::..||.|...:.:..|..:..::|..
Mouse   247 --------------GQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYA 297

  Fly   321 NILIVGGSAQFPGFLPRLKRDLRALVPDDLEVSLICPEDPVRYAWYGGKEVATSPNFEEFVYTQD 385
            |.::.||:..:||...|:::::.||.|..:::.:|.|.:.....|.||..:|:...|::...|:.
Mouse   298 NNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQ 362

  Fly   386 DYEEYG 391
            :|:|.|
Mouse   363 EYDEAG 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp6	NP_511165.1	ACTIN	3..398	CDD:214592	106/396 (27%)
Arp6	NP_511165.1	COG5277	6..391	CDD:227602	105/394 (27%)
Acta1	NP_001258970.1	PTZ00281	4..377	CDD:173506	106/396 (27%)
		Interaction with alpha-actinin. /evidence=ECO:0000250\|UniProtKB:P68135	112..125		2/12 (17%)
		Interaction with alpha-actinin. /evidence=ECO:0000250\|UniProtKB:P68135	360..372		4/9 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54227
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930