DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HUWE1 and Magi3

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_001152826.1 Gene:Magi3 / 99470 MGIID:1923484 Length:1476 Species:Mus musculus


Alignment Length:1628 Identity:302/1628 - (18%)
Similarity:477/1628 - (29%) Gaps:567/1628 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  2217 KQSSSGGGAAAAGQTGQATEKFEPCCCTWHIPTSGHT---------HAKPTISRATLL--KLLAD 2270
            :..:.|||......:|:|....:........|.||.|         |.:..|...|:.  |::..
Mouse    49 RDEAGGGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINK 113

  Fly  2271 STRAYQSL----------VPRVLLSHVY---------TPADSPL-------ISAPQQTFL---GV 2306
            ..|.|.||          :.:|:..::|         .|.|..:       ||..|...|   |.
Mouse   114 DLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGA 178

  Fly  2307 LLD---------------------------------RFLPITQRHHVPEVSTMTRVLICSLSDCY 2338
            ||:                                 .|...:||.....||.|.| :..||.:  
Mouse   179 LLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDTESQRKRTTSVSKMER-MDSSLPE-- 240

  Fly  2339 QQPGVQVHVAEELHAAVARALAQPDSAEKHTRL-QVLMSLFPNLIESPMLYD-KVHMHRNNMYRV 2401
                    ..|:............::.|.|:.. ...|...|:..::....| :.:|.|:.....
Mouse   241 --------EEEDEDKEAVNGSGSMETREMHSETSDCWMKTVPSYNQTNSSMDFRNYMMRDENLEP 297

  Fly  2402 LLRQGVMTYL-TKVAQYKDLSNHNTLSTLAAILRPMEILLRFSVSTTTLGSKRILFGSGGPGGPN 2465
            |.:...|.|. |.:..:.|   |||                   .|||....|:...:   ..|.
Mouse   298 LPKNWEMAYTDTGMIYFID---HNT-------------------KTTTWLDPRLCKKA---KAPE 337

  Fly  2466 ASGNGNNTAGGSSGNGPGSGNTYGTIINRRLYPRLAARTGFGSAME---RSNAMG---------- 2517
            ...:|....|......|..|..|...:|:        :|.|.:.:|   |...:|          
Mouse   338 DCEDGELPYGWEKIEDPQYGTYYVDHLNQ--------KTQFENPVEEAKRKKQLGQAEIHSAKTD 394

  Fly  2518 --GEHVLRD-------IIRNVLSDRRHAFEF-IFNSD--DMAVDSEDAAAPGSGVGGGGSGAGSV 2570
              ..|..||       ::|..|......|.| |...|  |..:..::....|.....|....|.|
Mouse   395 VERAHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDV 459

  Fly  2571 GGGVSGS-VSGNSSAAVIDV-----VEERSN---------GGDTNDPPANVSSASSGA-GQSSTS 2619
            ...::|: |.|::.|.|:.:     |.:..|         ..|:.||..::.:|:... |||.|.
Mouse   460 IVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTK 524

  Fly  2620 GGPVRPVVNFDQLWDDFLQSEGLRLASRSGGGAGSGSGSVGASS--SGQQNGSNTTASSTNSGNN 2682
            |.......:|         ..|..:..::|     .||.:.||.  :|....|...||..:||::
Mouse   525 GETCMNTQDF---------KLGAMVLDQNG-----KSGQILASDRLNGPSESSEQRASLASSGSS 575

  Fly  2683 SGIGNLRLRTNPDVDVGSGNG---SGSGSGSNAGVVNDN----GISGG----------------- 2723
            ..    .|.|.|.:....|.|   :.|.:|....::.|:    |:..|                 
Mouse   576 QP----ELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHL 636

  Fly  2724 ---------------------GG----SDGASTSSDTGAPGGARD-LNASLLGDV----STSESD 2758
                                 ||    :..|.|.:||....|:.: :|..:...:    |...|.
Mouse   637 QVVEVLKQFPVGADVPLLILRGGPCSPTKTAKTKTDTKENSGSLETINEPIPQPMPFPPSIIRSG 701

  Fly  2759 S---DPST---------ENDERNEEDEDE--------------DDDAPDEDV------------- 2784
            |   |||.         |:...|.:|.|.              ..|.||:.:             
Mouse   702 SPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEK 766

  Fly  2785 -------DEHSETDVDEERSRQFIEVFDHIYEPESSETASNDADV-----------DNDDDDDED 2831
                   ||....|....:.:...:|.|.:      .||:.:..|           :...:|:..
Mouse   767 DGRLRAADELMCIDGIPVKGKSHKQVLDLM------TTAARNGHVLLTVRRKIFYGEKQPEDESH 825

  Fly  2832 DVDDDDDDDEDNDDDV--REEVQSVMDAEIENRID--IALALVSSNNRPRRSAAVNASG---DGS 2889
            .....:.....|..::  |...|...|..::.:.:  ....:::|.::|......:..|   |||
Mouse   826 QAFSQNGSPRLNRAELPTRSAPQEAYDVTLQRKENEGFGFVILTSKSKPPPGVIPHKIGRVIDGS 890

  Fly  2890 -ANR------------TNPDDEVD-DEDDDVDADPDGDPDV-----------DPISGP-SAAQAE 2928
             |:|            .|....|| ..|:.|....|....|           .|.||. ||.|:.
Mouse   891 PADRCGGLKVGDHISAVNGQSIVDLSHDNIVQLIKDAGVTVTLTVVAEEEHHGPPSGTNSARQSP 955

  Fly  2929 AYLYERLGSGLMPTPPVGFRVRMNSSIAQPLDIDVNGGNAGSGSNAGATGSSGGSGQRSSTGGTT 2993
            |..:..:|.......| |.|:.:...|               |.:..::.....|..:......|
Mouse   956 ALQHRPMGQAQANHIP-GDRIALEGEI---------------GRDVCSSYRHSWSDHKHLAQPDT 1004

  Fly  2994 ASIGAIASAALRPSSGSWMAP------DFNFIRISGGDSSMG--------SGPAI-GGNANGGDM 3043
            |.|..:.|.. ..|.|.:...      .|.|....|.:.:||        .|||| .|..:.||.
Mouse  1005 AVISVVGSRH-NQSLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQ 1068

  Fly  3044 NVFITPSMSLERAGGAPGSGQTMS---ELLNEQPTGAGGGGGGGSA-----SGVGGVGANGGTTG 3100
            .|.|         .|.|..|.|.:   ||:.         .||...     .|.|.:..:|....
Mouse  1069 IVEI---------NGEPTQGITHTRAIELIQ---------AGGNKVLLLLRPGTGLIPDHGDWDT 1115

  Fly  3101 QHPNATLCTNGVRRRLLYLDQQYCVCMPTHQNPTEETQMETFTQDALHWWLEEATLLDMESQTDA 3165
            ..|:::        .::| |:|......:|...|.|......|:|:|             ::...
Mouse  1116 NSPSSS--------NVIY-DEQPPPLPSSHSASTFEESHVPATEDSL-------------TRVQI 1158

  Fly  3166 CLYAAHFLLPHLIKELKAAHQQRK------QEEAARQST-------TPASGSNASATS-----SS 3212
            |..|         :|||...|::|      |.|...||.       .|..||.....|     :.
Mouse  1159 CEKA---------EELKDTVQEKKSTLNGSQPEMKYQSVHKTMSKKDPPRGSGHGEKSRLKGENG 1214

  Fly  3213 TTSVVGTAAP--------------------------------TATSSIASGLLANAVSAGSG--- 3242
            .|....:|:|                                :.....:.|.|  .:.||||   
Mouse  1215 VTRRGRSASPKKSVNRHSEEHLEKIPRPLKSDPKEKSRDRSLSPRKGESKGRL--TIKAGSGQDP 1277

  Fly  3243 -------SSSLVVPPVAASATGGTRRSSIPVLISSTLGPSSASSATSATGNGATSDATTTTGGPT 3300
                   |||    |......||..       :|:|.|..|.:.:..|.|:...|......|...
Mouse  1278 NRKDRGRSSS----PKKQQKIGGNS-------LSNTEGKLSEAGSRRAAGHPRDSTEQLPDGREK 1331

  Fly  3301 RNFSSVDSNVSSETQTTTRPPRQRGGLRQQSQLPFNIYAEIDLTNEQDSEGDRSTSTTTGTAADG 3365
            ...|..|...|...:|.|:.|.::.....::.||                 .:.||:|.|.....
Mouse  1332 SGVSRKDLKQSQPGKTRTKSPEKKSSKVDETSLP-----------------SKKTSSTAGRVVSE 1379

  Fly  3366 AESQSQHNSSSTAAQVAVPQHQRHPPVPLLPSSGRPSR---PHTRLDETELLLLQLTDRQIRNRL 3427
            .|...:                        |::|..||   .||          |::.:|::...
Mouse  1380 KEKGKK------------------------PTAGETSRETVEHT----------QISAKQLKQEA 1410

  Fly  3428 QGSSGHTNSSRTSGSALINARPNRDLPACLQRHDHPAGSIFPRPS-----ANRTPAPTLVSMPTP 3487
            |..:...|:....|      |.:.....|.:|    ||.. |:.|     |..||.|..|    |
Mouse  1411 QEKTALGNADDHKG------RESEVTDRCRER----AGCT-PQSSSLVKKAPITPGPWRV----P 1460

  Fly  3488 MSN 3490
            .:|
Mouse  1461 RAN 1463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033
HECTc 4820..5148 CDD:214523
Magi3NP_001152826.1 Interaction with ADRB1 and TGFA. /evidence=ECO:0000269|PubMed:15652357 18..108 12/58 (21%)
PDZ_signaling 24..103 CDD:238492 11/53 (21%)
NK 125..>199 CDD:302627 11/73 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..266 12/92 (13%)
WW 297..329 CDD:197736 11/53 (21%)
WW 345..375 CDD:238122 7/37 (19%)
Interaction with PTEN. /evidence=ECO:0000250 413..495 18/81 (22%)
PDZ 416..496 CDD:214570 17/79 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..575 8/23 (35%)
PDZ 578..659 CDD:214570 10/80 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 664..691 6/26 (23%)
PDZ 729..812 CDD:214570 12/88 (14%)
Interaction with ADGRB1. /evidence=ECO:0000250 729..811 12/87 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..844 2/25 (8%)
PDZ_signaling 851..936 CDD:238492 16/84 (19%)
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250 852..939 16/86 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..966 8/26 (31%)
PDZ_signaling 1023..1101 CDD:238492 22/95 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1109..1151 9/50 (18%)
MIP-T3 <1166..>1431 CDD:287245 59/334 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1168..1476 71/375 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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