| Sequence 1: | NP_001285288.1 | Gene: | HUWE1 / 32510 | FlyBaseID: | FBgn0030674 | Length: | 5151 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001034568.1 | Gene: | AREL1 / 9870 | HGNCID: | 20363 | Length: | 823 | Species: | Homo sapiens |
| Alignment Length: | 529 | Identity: | 161/529 - (30%) |
|---|---|---|---|
| Similarity: | 252/529 - (47%) | Gaps: | 78/529 - (14%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 4677 PFMDDVSSANTPSSASFDDEPRMQDASTNTP-LVTNPS------TSTAMSAHEAQLRQDRQKFLQ 4734
Fly 4735 FAEKHRTVLNQILRQSPTH------LSDG---PFAVLVDHTRIL----------------DFDVK 4774
Fly 4775 RKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLL 4839
Fly 4840 REWYVIISREIF---NPMYALFCVSPGDRVTYMINPSSHANPN-----HLSYFKFVGRVIAKAVH 4896
Fly 4897 DNKLLECY-------FTRSFYKHILGKQVKHTDMESQDYEFYKG-LDYLMKNDISTLGYELTFST 4953
Fly 4954 E-VQEFG-VTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLI 5016
Fly 5017 SIFNEQELELLISGLPDIDIEDLKANT-----EYHKYTSKSAQIQWFWRALRSFDQADRAKFLQF 5076
Fly 5077 VTGTSKVPLQGFGSLEGMNGIQKFQ-IHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKA 5140
Fly 5141 IHECSEGFG 5149 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| HUWE1 | NP_001285288.1 | DUF908 | 90..326 | CDD:283630 | |
| DUF913 | 621..989 | CDD:283642 | |||
| UBA_like_SF | 1467..1506 | CDD:304366 | |||
| WWE | 1756..1828 | CDD:128922 | |||
| 40S_SA_C | 3575..3651 | CDD:292740 | |||
| DUF4414 | 3675..3779 | CDD:291075 | |||
| HECTc | 4796..5149 | CDD:238033 | 126/376 (34%) | ||
| HECTc | 4820..5148 | CDD:214523 | 120/351 (34%) | ||
| AREL1 | NP_001034568.1 | Filamin | 52..158 | ||
| Filamin | 56..154 | CDD:395505 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 315..345 | 10/30 (33%) | |||
| Interaction with SOCS2. /evidence=ECO:0000269|PubMed:31578312 | 483..789 | 104/325 (32%) | |||
| HECTc | 486..820 | CDD:214523 | 121/353 (34%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_COG5021 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D140374at33208 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.820 | |||||