DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and BAG3

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_004272.2	Gene:	BAG3 / 9531	HGNCID:	939	Length:	575	Species:	Homo sapiens

Alignment Length:	607	Identity:	133/607 - (21%)
Similarity:	210/607 - (34%)	Gaps:	165/607 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  3200 PASGSNASATSSSTTSVVGTAAPTATS------SIASGLLANAVSAGSGSSSLVVPPV------- 3251
            |:.|...:.:|::..|..|:..|.|..      .:..|.:...| ...|:.:..|.|.
Human    55 PSEGPKETPSSANGPSREGSRLPPAREGHPVYPQLRPGYIPIPV-LHEGAENRQVHPFHVYPQPG 118

  Fly  3252 -----AASATGGTRRSSIPVL-ISSTLGPSSASSATSATGNGATSDATTTTGGPTRNFSSVDSNV 3310
                 ..:|....:||..|:. :..|..|.......:|    |.:.....:.||.|:.|...|:.
Human   119 MQRFRTEAAAAAPQRSQSPLRGMPETTQPDKQCGQVAA----AAAAQPPASHGPERSQSPAASDC 179

  Fly  3311 SSETQTTTRPPRQRGGLRQQSQLPFNIYAEIDLTNEQDSEGDRSTSTTTGTAADGAESQSQHNSS 3375
            ||.:.:.:.|...|..|... |||.. |..|.:.:||:         .|..||    ..|.|.:.
Human   180 SSSSSSASLPSSGRSSLGSH-QLPRG-YISIPVIHEQN---------VTRPAA----QPSFHQAQ 229

  Fly  3376 STAAQVAVPQHQRHPPV------------PLLPSSGRPSRPHTRLDETELLLLQLTDRQIRNRLQ 3428
            .|.......::|.|.||            ||     |.:.|                  .|:.:|
Human   230 KTHYPAQQGEYQTHQPVYHKIQGDDWEPRPL-----RAASP------------------FRSSVQ 271

  Fly  3429 GSSGHTNSSRTSGSALINARPNRDLPACLQRH---DHPAGSIFPRPSANRTPAPTLVSMPTPMSN 3490
            |:|....|...|.:.|.:       |:.::.|   |.|     .:|..:|..||  ||.|
Human   272 GASSREGSPARSSTPLHS-------PSPIRVHTVVDRP-----QQPMTHRETAP--VSQP----- 317

  Fly  3491 AALEQLNVTAPDVVRTDRNFALPSSLEVDVDVLPGIVD---LPQQEAQPEDDQLLLPPPPP---P 3549
               |....:.|..|..:    ||.. .:.:.|:...||   :.|:...|.:...:..||.|   |
Human   318 ---ENKPESKPGPVGPE----LPPG-HIPIQVIRKEVDSKPVSQKPPPPSEKVEVKVPPAPVPCP 374

  Fly  3550 PPSDTTPLVHAEDDLWPGTVVSAGTREESSAPAVATESTEAVNESNQPEPTPESSESTSPNP--- 3611
            |||             ||.     :...||..:||||...|        |:...:|:|.|.|
Human   375 PPS-------------PGP-----SAVPSSPKSVATEERAA--------PSTAPAEATPPKPGEA 413

  Fly  3612 QAPSAEPTPLEPGAAVDASVGAQTPATTEEAASTAGASGTTATITDMSPEVRAALGDLEVPEGVD 3676
            :||...|..|:..|.::...|.:......|...|   ......|.:...:...||      :.||
Human   414 EAPPKHPGVLKVEAILEKVQGLEQAVDNFEGKKT---DKKYLMIEEYLTKELLAL------DSVD 469

  Fly  3677 PSFLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQI-AHDSLVEVNPEFLAALPLNIQSEVLMQQ 3740
            |...|.:....|:.|    .::|.|.::.:|.||.: ....:.|:.|.       |::::..:|.
Human   470 PEGRADVRQARRDGV----RKVQTILEKLEQKAIDVPGQVQVYELQPS-------NLEADQPLQA 523

  Fly  3741 RIEQQRQAA-----QTANPEDP 3757
            .:|....||     ...|.|||
Human   524 IMEMGAVAADKGKKNAGNAEDP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740	20/78 (26%)
		DUF4414	3675..3779	CDD:291075	22/89 (25%)
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
BAG3	NP_004272.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92		7/36 (19%)
		WW	21..53	CDD:197736
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..200		18/81 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..421		59/256 (23%)
		BAG	421..498	CDD:214591	17/89 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..575		5/14 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900