DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and TRIP12

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	XP_024308991.1	Gene:	TRIP12 / 9320	HGNCID:	12306	Length:	2092	Species:	Homo sapiens

Alignment Length:	2305	Identity:	455/2305 - (19%)
Similarity:	762/2305 - (33%)	Gaps:	695/2305 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  3175 PHLIKELKAAHQQRKQEEAARQSTTPASGSNASATSSSTTSVVGTAAPTATSSIASGLLANAVSA 3239
            ||...:.:...|:::.:.|...||:.|....:.||..|.:.     ....|.|       :.|.:
Human   149 PHSKSKKRHLDQEQQLKSAQSPSTSKAHTRKSGATGGSRSQ-----KRKRTES-------SCVKS 201

  Fly  3240 GSGSSSLVVPPVAASATGGTRRSSIPVLIS-----------STLGPSSASSATSATGNGATSDAT 3293
            ||||.|          ||...||:.|..::           ||:..||::::||::.:...|.::
Human   202 GSGSES----------TGAEERSAKPTKLASKSATSAKAGCSTITDSSSAASTSSSSSAVASASS 256

  Fly  3294 TTTGGPTRNFSSVDSNVSSETQTTTRP-PRQRGGLRQQSQL----PFNIYA----EIDLTNEQDS 3349
            |...| .|.....|.|.:..:::.:.| ||:....::||:.    .|:..|    ::.|...:.|
Human   257 TVPPG-ARVKQGKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLS 320

  Fly  3350 EGDRSTSTTTGTAADGAESQSQHNSSSTAAQVAVPQHQRHPPVPLLPSSGRPSRPHTRLDETELL 3414
            ....|.|.|:.....|.:::......||      .:....||..|         |..|
Human   321 LPGSSKSETSKPGPSGLQAKLASLRKST------KKRSESPPAEL---------PSLR------- 363

  Fly  3415 LLQLTDRQIRNRLQGSSGHTNSSRTSGSALINARPNRDLPACLQRHDHPAGSIFPRPSANRTPAP 3479
                  |..|.:..||...| |.|.||.....|...|       |.:
Human   364 ------RSTRQKTTGSCAST-SRRGSGLGKRGAAEAR-------RQE------------------ 396

  Fly  3480 TLVSMPTPMSNAALEQLNVTAPDVVRTDRNFALPSSLEVDVDVLPGIVDLPQQEAQPEDDQL--- 3541
               .|..|.||.  |.:|.:|   .|||.   .|........|...:......|::.:|.::
Human   397 ---KMADPESNQ--EAVNSSA---ARTDE---APQGAAASSSVAGAVGMTTSGESESDDSEMGRL 450

  Fly  3542 -LLPPPPPPPPSDTTPLVHAEDDLWPGTVVSAGTREESSAPAVATESTEAVNESNQPEPTPE--- 3602
             .|......||....||......|:..|:.|..    ||......:..:|.:||.|.:...|
Human   451 QALLEARGLPPHLFGPLGPRMSQLFHRTIGSGA----SSKAQQLLQGLQASDESQQLQAVIEMCQ 511

  Fly  3603 ----SSESTSPNPQAPSAEP---TPLEPGAAVDASVGAQTPATTEEAASTAGASGTTATITDMSP 3660
                .:|.|.......|..|   |.|:    ::.:......|.............::|.:.|..|
Human   512 LLVMGNEETLGGFPVKSVVPALITLLQ----MEHNFDIMNHACRALTYMMEALPRSSAVVVDAIP 572

  Fly  3661 EVRAALGDLEVPEGVDPSFLAALPSEM-----REEVIQEH------LRMQRIRQRAQQNAIQIAH 3714
               ..|..|:|.:.:|.:..|....||     .:.::|..      |.::.....||:||:.||.
Human   573 ---VFLEKLQVIQCIDVAEQALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAA 634

  Fly  3715 DSLVEVNPE---FLA-ALPLNIQSEVLMQQRIEQQRQAAQTANPEDPVDTAAFFQNL------PE 3769
            :....:.|:   |:| :|||      |.|:...|.:::.::        |...|..|      .|
Human   635 NCCQSITPDEFHFVADSLPL------LTQRLTHQDKKSVES--------TCLCFARLVDNFQHEE 685

  Fly  3770 NLRQAI-----LTDMEESQIASLP---------------------PELAAEAQFLRRD------- 3801
            ||.|.:     ||::::..:.:.|                     |.||  .|.::::
Human   686 NLLQQVASKDLLTNVQQLLVVTPPILSSGMFIMVVRMFSLMCSNCPTLA--VQLMKQNIAETLHF 748

  Fly  3802 --WESRNGA---RMDAHP--------------------PSNALSRFQTTL-----QSLDDTRWHS 3836
              ..:.||:   ::|..|                    |...:....|.|     |:.|...|.
Human   749 LLCGASNGSCQEQIDLVPRSPQELYELTSLICELMPCLPKEGIFAVDTMLKKGNAQNTDGAIWQ- 812

  Fly  3837 SIWYDASGNAQPQHHQHTTIVHQHPHAHHAPNMGKPLALLMMEDENILLDPDSLATLLLFLFVED 3901
              |.|..|...|.:...:.|:....|     .:|        |||      .||:||.....::
Human   813 --WRDDRGLWHPYNRIDSRIIEVAAH-----QVG--------EDE------ISLSTLGRVYTID- 855

  Fly  3902 QKVNSMRLHRVIRNLCHHEPTRDWIISALISIIQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGY 3966
              .|||                           |:.|||.....|.|....|    |......||
Human   856 --FNSM---------------------------QQINEDTGTARAIQRKPNP----LANSNTSGY 887

  Fly  3967 KSNIFLINRLYEGSARSISINPQAAQMIVRNCLDLLFVLAKHYPSSFVPFNRDVKARRILSAVFG 4031
            ..     ::..:..|:.:..:|:.|:..::.   |..||.:.|.||..|..|....|.||..::.
Human   888 SE-----SKKDDARAQLMKEDPELAKSFIKT---LFGVLYEVYSSSAGPAVRHKCLRAILRIIYF 944

  Fly  4032 MPSPTAGS--GGGAGSGSAASGGLTGYDDVPPGGTLD------------FRSRFCRYQVVNRLRS 4082
            ..:.....  ...|.|...|| .|:..|.....|.|.            |...|.|..|:::::.
Human   945 ADAELLKDVLKNHAVSSHIAS-MLSSQDLKIVVGALQMAEILMQKLPDIFSVYFRREGVMHQVKH 1008

  Fly  4083 IFDDH---PAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAGSQNKHSVPYQTNAKNFWDVVLNID 4144
            :.:..   .:|..:.........|..:.:...|||....|......|:.:..:.        ::|
Human  1009 LAESESLLTSPPKACTNGSGSMGSTTSVSSGTATAATHAAADLGSPSLQHSRDD--------SLD 1065

  Fly  4145 QQTQVRLANV---AQFPLTSQPAWEWQP--------NTADFLSFSESPFGQLLEMLPYKVICRSP 4198
            ...|.||::|   .:.|.......::.|        |.|...:.::||              :|.
Human  1066 LSPQGRLSDVLKRKRLPKRGPRRPKYSPPRDDDKVDNQAKSPTTTQSP--------------KSS 1116

  Fly  4199 HLTDMLVKLLASLSTELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENTATAT 4263
            .|..:..|....|||:.....              |.|.:.||.:..|.        |.:..|.:
Human  1117 FLASLNPKTWGRLSTQSNSNN--------------IEPARTAGGSGLAR--------AASKDTIS 1159

  Fly  4264 EIGDGLAANIEEQASPASGNPASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVI 4328
            ...:.:...|:|||.                               ....|...|:|.......:
Human  1160 NNREKIKGWIKEQAH-------------------------------KFVERYFSSENMDGSNPAL 1193

  Fly  4329 EVLTHQCGTTEGL----DNVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIR 4389
            .||...|..||.|    |..|:.:|                          |:|..:..  :::.
Human  1194 NVLQRLCAATEQLNLQVDGGAECLV--------------------------EIRSIVSE--SDVS 1230

  Fly  4390 MYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAP--- 4451
            .:.|..            ||.......|:.:.|...     ||...|...||.  ||..|:|
Human  1231 SFEIQH------------SGFVKQLLLYLTSKSEKD-----AVSREIRLKRFL--HVFFSSPLPG 1276

  Fly  4452 ----KNAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIF-MQVRDMYEAQNGLSTGG--------- 4502
                ...:|.....|.::...|:|..:|      ::.| ::|.| :.:.||  |||
Human  1277 EEPIGRVEPVGNAPLLALVHKMNNCLSQ------MEQFPVKVHD-FPSGNG--TGGRGSQALKFF 1332

  Fly  4503 ---GVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTISPPPPMETNQIAQD----GDDDEE 4560
               .:.|....:.|.....:..||          |.....::....:|...:.:.    .:|||:
Human  1333 NTHQLKCQLQRHPDCANVKQWKGG----------PVKIDPLALVQAIERYLVVRGYGRVREDDED 1387

  Fly  4561 DDDEARSFPGVGNHAVASASKSTKPTLSQILC-LDVLW-NTLSECLVALEE--------SKDEFA 4615
            .||:     |.......|..:...||:..:|. :..|| ..|..|.:...:        .:.:|.
Human  1388 SDDD-----GSDEEIDESLVRYYIPTMYNVLYKVQGLWLKWLLLCFIQAAQFLNSGNVRHRLQFY 1447

  Fly  4616 V--------LVLQPTVEAFFLIHASHRGA----SKKSGRSFMPNAAGFGLRA------------A 4656
            :        :.:...|..|.:.....|.:    |...||      ||...:.            .
Human  1448 IGEHLLPYNMTVYQAVRQFSIQAEDERESTDDESNPLGR------AGIWTKTHTIWYKPVREDEE 1506

  Fly  4657 AGAGAIGGLGAAAPSAQEYSPFMDDVSSANTPSSASFDDE-------PRMQDASTNTPL-----V 4709
            :....:||....|.:|          .:..:|.:|...||       |     |.:.||     .
Human  1507 SNKDCVGGKRGRAQTA----------PTKTSPRNAKKHDELWHDGVCP-----SVSNPLEVYLIP 1556

  Fly  4710 TNPSTST----------------AMSAHEAQLRQD--------RQKFLQ---FAEKHRTVLNQIL 4747
            |.|...|                |:|.:...|..:        ..:|:.   .|:.:|.:.:.::
Human  1557 TPPENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQLQDPLV 1621

  Fly  4748 RQS---PTHLSD----GPFAVLVD----------------HTRILDFDVKRKYFQTELERLDEGI 4789
            ..:   ||.|::    .||....|                ..|:||.:.:.....::..|:...:
Human  1622 IMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRL 1686

  Fly  4790 RREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPM 4854
            .|::.||:  |..:.:.:..|:..||..  :....|.:|:|.|...|..| |:|.::|:|:....
Human  1687 DRKKRTVN--REELLKQAESVMQDLGSS--RAMLEIQYENEVGTGLGPTL-EFYALVSQELQRAD 1746

  Fly  4855 YALFCVSPGDRVTYMINPSSH---------------------ANPNHLS----YFKFVGRVIAKA 4894
            ..|:   .|:.|| :.||...                     |.|.|::    .|:|:|:::|||
Human  1747 LGLW---RGEEVT-LSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKA 1807

  Fly  4895 VHDNKLLECYFTRSFYKHIL------------------GKQVKHTD--------MESQDYEFYKG 4933
            :.|.:|::......|||.:|                  .:.|.|.:        :|....:..:.
Human  1808 IMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKES 1872

  Fly  4934 LDYLMKN------DISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKM 4992
            |.|.::.      .:..||.:.|..      |...| :||..|:|..||..|..||::||....:
Human  1873 LQYALETLTMNGCSVEDLGLDFTLP------GFPNI-ELKKGGKDIPVTIHNLEEYLRLVIFWAL 1930

  Fly  4993 SGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEY----HKYTSKSA 5053
            :..:.:|.|:|.:||..:.|...:..|..:||:.|:.| ...|..|.|...|.    |.||..|.
Human  1931 NEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCG-SKADTWDAKTLMECCRPDHGYTHDSR 1994

  Fly  5054 QIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTC 5118
            .:::.:..|.|||...:..|||||||:.::|:.||.||.....|.:......:...|.||...||
Human  1995 AVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTC 2059

  Fly  5119 FNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            .|.|.||.|.|.:.:|..||.|..|..:.|
Human  2060 VNYLKLPDYSSIEIMREKLLIAAREGQQSF 2089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740	14/85 (16%)
		DUF4414	3675..3779	CDD:291075	30/129 (23%)
		HECTc	4796..5149	CDD:238033	110/414 (27%)
		HECTc	4820..5148	CDD:214523	104/388 (27%)
TRIP12	XP_024308991.1	SR-25	99..>233	CDD:313680	23/105 (22%)
		Arm_3	489..>714	CDD:330530	49/245 (20%)
		WWE	808..874	CDD:308464	23/117 (20%)
		HECTc	1690..2090	CDD:238033	111/417 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900