DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and HERC3

DIOPT Version :10

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_055421.1 Gene:HERC3 / 8916 HGNCID:4876 Length:1050 Species:Homo sapiens


Alignment Length:435 Identity:107/435 - (24%)
Similarity:193/435 - (44%) Gaps:51/435 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly  4747 LRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELE-------------------RLDEGIRRE 4792
            ::..|:.:.|  ...|..:..|.|...|.|..||:.|                   .|:..:.|.
Human   637 MKARPSIIQD--TVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARS 699

  Fly  4793 EHTV-SVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYA 4856
            ...| .|||..:..|:.|.|......:.|....::|:.||..||||:.:|:::::.:|:.||:|.
Human   700 PFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYG 764

  Fly  4857 LFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILG------ 4915
            :|.......:.:.   |......| ::|..:|.....|::::.:::.:|..:.||.:|.      
Human   765 MFTYYQDSNLLWF---SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLE 825

  Fly  4916 --KQVKHTDMES-QDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTE 4977
              |::..|:..| |:...|.|      .|:... :.|.|:...:.:||.:.:.|.|.|.:..|.:
Human   826 DLKELSPTEGRSLQELLDYPG------EDVEET-FCLNFTICRESYGVIEQKKLIPGGDNVTVCK 883

  Fly  4978 ENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKAN 5042
            :|:.|:|..........|:.:...||..||..:....::.:|...||..::.|..:.:.|:|:..
Human   884 DNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEET 948

  Fly  5043 TEYH-KYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDD 5106
            ..|. .|::....::.||.....|....:.|||.|:||:.::|:.|..||:       ..|....
Human   949 AIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ-------IVIQSTA 1006

  Fly  5107 RSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFGFA 5151
            ...:.||.||||:|.||||.|.|.:.|.:.|.:|: :..|||..|
Human  1007 SGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQAL-DNYEGFSLA 1050

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:428721
DUF913 621..989 CDD:461803
UBA_like_SF 1467..1506 CDD:473871
WWE 1756..1828 CDD:128922
DUF5585 3288..3672 CDD:465521
UBM 3670..3700 CDD:464159
UBM 3719..3746 CDD:464159
HECTc 4796..5149 CDD:238033 93/363 (26%)
HERC3NP_055421.1 RCC1 1 1..51
ATS1 3..341 CDD:444065
RCC1 2 52..101
RCC1 3 102..154
RCC1 4 156..207
RCC1 5 208..259
RCC1 6 261..311
RCC1 313..377 CDD:395335
RCC1 7 313..366
HECTc 702..1048 CDD:238033 93/364 (26%)
Blue background indicates that the domain is not in the aligned region.

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