DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and HUL4

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_012570.3	Gene:	HUL4 / 853494	SGDID:	S000003797	Length:	892	Species:	Saccharomyces cerevisiae

Alignment Length:	465	Identity:	129/465 - (27%)
Similarity:	220/465 - (47%)	Gaps:	55/465 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  4726 RQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELER------ 4784
            :||...:...|:|  |.:||::.:.....:...|: ...:..||...:|....:.|:.|
Yeast   442 KQDFDHWRGVAQK--TKMNQLIEEWGNSTTKKCFS-FCKYPFILSLGIKISIMEYEIRRIMEHEA 503

  Fly  4785 -------LDEGIRREEH-TVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLRE 4841
                   ||:|...:.: .:.|||..:..||.|.:.....:..|: ..|.|.:|.|.|||||.:|
Yeast   504 EQAFLISLDKGKSVDVYFKIKVRRDVISHDSLRCIKEHQGDLLKS-LRIEFVNEPGIDAGGLRKE 567

  Fly  4842 WYVIISREIFNPMYALFC-VSPGDRVTYMINP----SSHANPNHLSYFKFVGRVIAKAVHDNKLL 4901
            |:.::::.:||||..||. :....|..:.|:|    .|....:.|..:...|.|:..|:.::.:|
Yeast   568 WFFLLTKSLFNPMNGLFIYIKESSRSWFAIDPPNFDKSKGKNSQLELYYLFGVVMGLAIFNSTIL 632

  Fly  4902 ECYFTRSFYKHILGKQVKHTD----MESQDYEFYKGLDYLMKN--DISTLGYELTF--------- 4951
            :..|.::.||.:..:.:...|    .........|.|:|...|  |:.:|.:|.|:
Yeast   633 DLQFPKALYKKLCSEPLSFEDYSELFPETSRNLIKMLNYTEDNFEDVFSLTFETTYRNNNWILND 697

  Fly  4952 STEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPK-HL 5015
            |...:|:...::.:   |||:..:|:.||.|:|....:..:..||..|.:.|:.||..:..: :.
Yeast   698 SKSSKEYVTVELCE---NGRNVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNS 759

  Fly  5016 ISIFNEQELELLISGLPD---IDIEDLKANTEY-HKYTSKSAQIQWFWRALRSFDQADRAKFLQF 5076
            |.:||.:|||.|:.|..:   .|.:.|::.|:| ..::..|..:.|||..:.|:|...:.|.|||
Yeast   760 IKLFNSEELERLVCGDEEQTKFDFKSLRSVTKYVGGFSDDSRAVCWFWEIIESWDYPLQKKLLQF 824

  Fly  5077 VTGTSKVPLQGFGSLEGMNGIQKFQIH-RDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKA 5140
            ||.:.::|..|..::       .|:|. .....:|.||.||||||::.|..|.|..||...||.|
Yeast   825 VTASDRIPATGISTI-------PFKISLLGSHDSDDLPLAHTCFNEICLWNYSSKKKLELKLLWA 882

  Fly  5141 IHECSEGFGF 5150
            |:| |||:||
Yeast   883 INE-SEGYGF 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	111/378 (29%)
		HECTc	4820..5148	CDD:214523	104/353 (29%)
HUL4	NP_012570.3	HUL4	1..892	CDD:227354	129/465 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810