Protein Alignment HUWE1 and TOM1

DIOPT Version :9

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_010745.3
• Gene: TOM1 / 852068
• SGDID: S000002865
• Length: 3268
• Species: Saccharomyces cerevisiae
• Alignment Length: 5372
• Identity: 975/5372 - (18%)
• Similarity: 1614/5372 - (30%)
• Gaps: 2341/5372 - (43%)

  Fly     9 KKGSSELTAECRELIDELTKRRTRAELLEFLDTVHVWIYGKCELYHWIEILDRFD-KILEEASRH 72
            |....:|.|..:.|:|.|....| ...||.::.:..|...:.:||.||.||||.| .:|:.|.::
Yeast     9 KARKEKLAAGYKPLVDYLIDCDT-PTFLERIEAIQEWDRSRDDLYVWIPILDRMDGLLLKVAEKY 72

  Fly    73 VNGNEFVLQCDTNFQET---DVTLLLHVLNFTTLLIEHSFSRHLYNSIEHLTVLLSSQNMDIVLA 134
            ....:...:|:....|.   ||...|.:|.||..|:.::.:|.:|:|.:.|..||:..|..|.||
Yeast    73 KYKQDPKKECEVKLVEMEAHDVDYCLKMLKFTRRLLLNTENRFVYSSGDVLMYLLNCPNFTIKLA 137

  Fly   135 VLNLLYMFSKRSNFIPRLPFEKKELLIVKLFNIAERWGDPNYGLSLKDCCIGEPKLEFLYQLCID 199
            |:.:|.:..:|  |:    ..:::::...:|      ||.|         :.:..|:....|...
Yeast   138 VMRILAILGER--FV----IAREKIVAHNIF------GDHN---------LRKKTLKLALSLSSS 181

  Fly   200 YVDEHGHAAQLEIPDMMDLCHTASAPEVIKTIAGQISKPSEAIKMRIAHRVRLISGFNNYKLRLQ 264
            .:||.|     |...::||.....            ..|.:..|:|..|...     |::|...|
Yeast   182 VMDEDG-----EHFSLVDLYFDKK------------KVPQKWRKLRFTHYTS-----NDFKKSSQ 224

  Fly   265 FVQARLQAVSILIYSNALQDNTDKVLYAGFGEELCE------------LIDKEDVHLVEIRAAVL 317
                  |..:|    |..|.:..||...  .:||||            |:..|......|:|:|.
Yeast   225 ------QKNNI----NETQTSIKKVTMT--TQELCEHSLQQIFDKGMALLPAESWFDFSIKASVA 277

  Fly   318 RTLTSMLHFDRNPNV-----------------------PRAGSRLMKIVHY-------------T 346
            :..:.    |...|:                       |:..|:|.::..|             |
Yeast   278 KAFSD----DSGENIDLRNIIIETKLNAIAFVNTIFSPPQVSSKLFELDPYAFNSLTDLISLSET 338

  Fly   347 GAERQGGTLPLLVRDCID-----------NL---TTHGLTERYPLILATSLFSLLYHLASYEMGG 397
            ...::..|..|...:||.           ||   .:|||           ||.:|.::|......
Yeast   339 KIPKELRTDALFTLECISLKHVWCSDIIRNLGGNISHGL-----------LFQILRYIAKTLREA 392

  Fly   398 TALVKSGMMQSLLCVISWPGVDLEHITFVTRAVRVIDLITNI-DIARFHQNNGLNVFIDRLEK-- 459
            |                 ..:|.|:      .||...||:|: |:...|::......|..|.:
Yeast   393 T-----------------DEIDEEY------NVRFFYLISNLADVKPLHESLFAAGLIPTLLEIV 434

  Fly   460 EIKSCCKALADIGITLKESTLRDDHKLDTSLDHVDEDVE--DGSGENASVTSGNASPRRDNSSDG 522
            .|::|         ..|.:.....|.|:|.:|:.:...|  :..|....:||
Yeast   435 SIRNC---------PYKRTLASATHLLETFIDNSETTTEFIENDGFTMLITS------------- 477

  Fly   523 ATGAGSIVYRAYHEHIGGAGSGAGLLDIGGARSSLSGGSSGTSGMGAGSINRDGSAARPP--AIM 585
              .|..|.:...|.                                        ...:||  :::
Yeast   478 --VANEIDFTLAHP----------------------------------------ETWQPPKYSVV 500

  Fly   586 YPTNSYYARPLAERKAELSSQLPSSLAPKKPSCVTQRAALLKSMLNFLKKSIQDHAHFSNMRNIM 650
            |.:.|:  |.||..:                       :|||.:|..|.....|     .:||::
Yeast   501 YYSISF--RELAYIR-----------------------SLLKLVLKLLSTDSGD-----RIRNLI 535

  Fly   651 ETSLTQSLRHIIANAEYYGPSLFLLATDVVTVYVFNEPSLLSSLQDLGITSVMLKALLQKDVPAT 715
            ::.:..||:.|:.|...:|.:|.....|||...:.:||::...|.:.|:...::.. ..|.:..:
Yeast   536 DSPILVSLKKILENKLVFGLTLITYTLDVVQKVINSEPTIYPVLVEAGLIPYVIDN-FPKLIGPS 599

  Fly   716 REVLGSLPNVFSALCLNERGLFEFLSYDPFDKVLKVLLSPDYLVAMRRRRSSDPLGDTATNLGNA 780
            .|:|..||:|.||:|||..||.:.......:.:...||..|:...:..       ||.:|..|..
Yeast   600 AELLSLLPDVVSAICLNPEGLKQVKEKGLINNLFDFLLDADHARILTG-------GDRSTEYGTD 657

  Fly   781 MDDLIKHHPYLRADATEAIVRLL--------NE---LVRLGSDPSFICWRANKESSGSGSGSGSH 834
            :|:|.:|:|.|:|:..||:..::        ||   |.....|..:...|.|:|..   :....|
Yeast   658 IDELARHYPDLKANIVEALCNVIRKMPSTFRNEREFLFTSPKDQKYFFHRKNEEIL---TDKEEH 719

  Fly   835 GGGHHVASTPSPMVMVAGTGSASSVLQGAADTNDSSGDDDDDDDEMSSASQQQQQPTTPGQGGGP 899
            ...:........|:     .:.:|||.|.:
Yeast   720 EPAYWELLDKGTML-----DTFTSVLFGMS----------------------------------- 744

  Fly   900 STPRTQQAGGVVGSGAGATGTPAAASQAVKVVTPPEREAIPLIDYILNVMKFIEAIFSNSPNGDH 964
                       :|:|:                                        ||..|....
Yeast   745 -----------LGNGS----------------------------------------FSQVPQHLE 758

  Fly   965 CREFVLHGGLKPILQLLSLPNLPVDSPVSTTSQAVANVCKAILSQAQETKVLDVA----LKQLAD 1025
            .|:|         |.::.:.|.|.:   ..||.|::||.:.:  |..:.|..|.|    :|.|.|
Yeast   759 ARDF---------LAIIFMENPPYE---YFTSVAISNVTEVL--QYLDEKYEDYAFMDVMKVLND 809

  Fly  1026 IVAQLKPLIKHFTFPGGSVLLAELVCCQRLEDGFANAEYTPILHNMSFVHGYVVML---VHLCRN 1087
               ||:.|......|.......|       .||         .:::...|..:..|   :::..|
Yeast   810 ---QLENLNDFLNSPNDRSFFLE-------RDG---------ENSVRSCHSKLCRLAAILNIVTN 855

  Fly  1088 ASNDMRTILLKRWGVNRETGVQLLQQLVQLY-------ISLVWESTILLNLCSDEP---TQH-PD 1141
            ...|:.|:..||              ::|:|       .||:....:|...|:.|.   .|| ||
Yeast   856 VYIDLTTLSCKR--------------IMQIYSYFDKRGFSLIKNLKLLFQKCALEEMYIRQHMPD 906

  Fly  1142 -LIWDEIAAQMSAAAGTADPL----TEAELSRKLERAAEFRTKYTPEEQFRYIKSLLAASSRLGR 1201
             :|.:.:...:...:|...||    .:.:...:..:....:|:.|  .|.|.|...|.:::
Yeast   907 SVITETMPLPIVDVSGDGPPLQIYIDDPKKGDQKGKITSVKTRNT--LQMRTILYTLQSNT---- 965

  Fly  1202 ALAELLGTLVKLSVGSPQTRQRR--------INDLISNITKVPTPEAREIARILSSILV--NGFS 1256
              |.|....::||.......:.:        ..:::.|:  :...:|.|:...|..|||  |..:
Yeast   966 --AILFRCFLRLSHSRNMDLEHKDLTTEVHIFENVVENV--IEMLKATELEGHLPYILVLLNFNT 1026

  Fly  1257 HESILPKPVPK----LKL--TFLICSVGFTGPMLFDDKRSAFHLMISQFCAENGLKAFFEMFYWA 1315
            ....:||..|.    |:.  .::....|  |.:|:      .|::...|.....:|..
Yeast  1027 FVFTIPKASPNSTEILQTIPAYIFYQKG--GYLLY------LHIIRDLFTRMTKIKDL------- 1076

  Fly  1316 LSLDNVSQKFEFDQWASMEDLMQSHEDDKRDCPEGTGEFLDAWLQLLEKMVNPRAM------LDS 1374
            .||||::...|.:...::..|:.:.            .|.:..:| .|.|.|.:::      :|.
Yeast  1077 SSLDNINYIDESNGILTLSCLINAL------------TFYNKSMQ-TETMENVQSIGKYYVSIDD 1128

  Fly  1375 PYTMSPRLNYMPDSVPFEPVFYLIHIHQLAM-------QALRRIWARRPIPNYGPSMFETMILIL 1432
            .|.:...|     :||       |.:..|||       .:|.:..:|    |...|:|:.::.:|
Yeast  1129 DYNIMKAL-----TVP-------IKVMALAMILDLDKSDSLFKTQSR----NVPYSVFKQLLSML 1177

  Fly  1433 KHLIKSHQTLLDRYHTRMKEIKFENLYIRSTDDGLNADHIKTLTDMGFMHYHVIEALRTNASLEE 1497
            |::                   |.|:.|          :.|.|.:   :|:.:|.......||.|
Yeast  1178 KNI-------------------FTNVNI----------YTKELYE---LHWDLIFPPIKKISLFE 1210

  Fly  1498 ATDYLLNNPEASSLSTTGGQSSSSAPPPPPPPSASTMDIDVDVPADGESTQSKSSTSPNSSYDYK 1562
            ... :..:..|:.|:.||.                      |:|||    .|....||.....||
Yeast  1211 QVG-IPGDVAANYLTDTGD----------------------DLPAD----NSIGLFSPEQWEKYK 1248

  Fly  1563 HL-----------------------KLMPSLIFDRFCDEAISRAFEFMEAIPDTVNSAADLIAVL 1604
            .|                       |.:..|....|.|...||.|..:...|..||:.|..:..:
Yeast  1249 KLIGEDKSIYYPQPMQAQYYKGCSSKELDELRDTFFNDGLPSRIFTVLPFYPKLVNAFAKTLLQI 1313

  Fly  1605 YRRHNHLNKQVFVTNFVRNIIQWVDFTLQLFEPAKTTGSKASRLEECLTGMTATRLFVRLKTSTL 1669
            :.:::. ..:||....:..|::     ..|.:||              |..:...||      .:
Yeast  1314 FTKYDE-PTEVFAGRILDRILE-----TDLDDPA--------------TLSSLIHLF------GI 1352

  Fly  1670 LLEENY-----SDLHRPLVEAITAQDAMVSLVKLLDCMSQWMLEQSTETNTGQQRATVPRWVQNL 1729
            .|.|.|     |.|.:..:|                     .||:|.:    .:....| |....
Yeast  1353 FLNEKYIYQKASHLMQRFIE---------------------YLEKSLK----PEHVNTP-WFSKA 1391

  Fly  1730 VDLIDAIDSISHILQRKANMRAVSSDVWRWYDASTGKWNAYSEANNELIRNAYAAGERWLYINIG 1794
            :.:.:.|.:.|.:    .::..:|.||...|
Yeast  1392 LYVYEIILAKSEL----PHLEELSKDVLLRY---------------------------------- 1418

  Fly  1795 RQRCTVSLNCMTQVSEASGTHRPVCPALKLSEAITSLNNPVALHKVEHILNRVVRTAPDGSGTVH 1859
                                     |.|.::             ||..|        ||......
Yeast  1419 -------------------------PLLSMA-------------KVFRI--------PDPMKQKL 1437

  Fly  1860 SDELISLRQLVNFTDGQQPQQSENSANPSEEATSEDGPAAANSGSPPATMTTRSKTRQKSAAAAA 1924
            .|.||.:..:.||.              |..|||.             .:...|:..       .
Yeast  1438 FDILIRVSDISNFY--------------SALATSR-------------ILIFYSRDE-------L 1468

  Fly  1925 AAKNKSQSGGSPPIPKRTQKIILNEEQVGLSKFDCGRIIGSIVDLLQPSHQMLNETKLSLLRLCA 1989
            .|.|.::||    |..|..|:|.:.:::....|                   |..:.|.|.|.|.
Yeast  1469 YANNIARSG----ILSRLLKVIGSFQKLDKINF-------------------LESSFLLLTRRCF 1510

  Fly  1990 RLTRNYDNAQVFIRRGGVRMLLHLQQACSFMGFPTYANIILRHVLEAPPVLQEAMERVLGMRAAG 2054
            ..|.|.|                                         .:::..:.|....|..|
Yeast  1511 ETTENVD-----------------------------------------ALIRAEINRSFTARPLG 1534

  Fly  2055 IVPVGHRDLIYVLTQVSSAVSRNPQIFVAAAKEMLKGEYLINTNSTTLADDARVMV----KSKFG 2115
            ......|:|..:|.:.:..|.|:|..|:         :.|..|......||...:|    |...|
Yeast  1535 GGDDAVRELTTILEEKAHVVMRSPSQFI---------DVLCETARFHEFDDQGALVDYSLKRFLG 1590

  Fly  2116 QQPTAAAGGATPHNQTPTPPPAAKDELKDDPQVQSSVAVLKELLHGLV---QPCWHYGGTGSLDR 2177
            ::.......:|.               |.|  :.....::..||..|:   :..|......|.|.
Yeast  1591 EKDKNTQASSTE---------------KSD--IYERTGIMHLLLSQLMAASEKDWLSEPANSSDL 1638

  Fly  2178 GQGAAELLQPDQPPGTAQGCHDDELYFRFQETPAPVSSKKQSSSGGGAAAAGQTGQATEKFEPCC 2242
            .:.....|.|.:.|                                                  .
Yeast  1639 PENKKAQLDPSRNP--------------------------------------------------V 1653

  Fly  2243 CTWHIPTSGHTHAKPTISRATLLKLLADSTRAY-QSLVPRVLLSHVYTPADSPLISAPQQTFLGV 2306
            |.:.|               .|||||.:...:| |.....:..|...|.|:.|   .|:.|.:..
Yeast  1654 CAYMI---------------FLLKLLVELVSSYNQCKFEFLTFSRRNTYAERP---RPRTTAINF 1700

  Fly  2307 LLDRFL--PITQRHHVPE------VSTMTRVLICSLSDCYQQPGVQVHVAEELHAAVARALAQPD 2363
            .|.|.|  |:...|...|      :..:.|.:|.         |....|.::........||.|.
Yeast  1701 FLYRLLDKPVGTDHDKHEAKRREVIGMLARSVII---------GFLATVQDDRTTKTDVKLADPH 1756

  Fly  2364 -SAEKHTRLQVLMSLFPNLIESPMLYDKVHMHRNNMYRVL----------LRQGVMTYLTKVAQY 2417
             :..:...::.::....|...|..|.:..|:..:..:|::          |||.:.:...:..||
Yeast  1757 MNFIRKFAIEAIIKAIRNATSSSKLLESNHLKLDMWFRIITSMVYVQAPYLRQLLDSNKVEADQY 1821

  Fly  2418 K------DLSNHNTLSTLAAILRPMEILLRFSVSTTTLGSKRILFGSGGPGGPNASGNGNNTAGG 2476
            :      ||...:.::...|           |:......||:|
Yeast  1822 QLCKLVIDLGLPSVITEAMA-----------SIDLNYPFSKKI---------------------- 1853

  Fly  2477 SSGNGPGSGNTYGTIINRRLYPRLAARTGFGSAMERSNAMGGEHVLRDIIRNVLSDRRHAFEFIF 2541
                                         |..|:|              ..|.:|..|:.|...|
Yeast  1854 -----------------------------FNVAVE--------------ALNTISSTRNNFSEHF 1875

  Fly  2542 NSDDMAVDSEDAAAPGSGVGGGGSGAGSVGGGVSGSVSGNSSAAVIDVVEERSNGGDTNDPPANV 2606
            ..:|.                                         |.||:..:..|..:.|
Yeast  1876 KIEDH-----------------------------------------DEVEDEVDESDKEEIP--- 1896

  Fly  2607 SSASSGAGQSSTSGGPVRPVVNFDQLWDDFLQSEGLRLASRSGGGAGSGSGSVGASSSGQQNGSN 2671
                                       |.|
Yeast  1897 ---------------------------DMF----------------------------------- 1899

  Fly  2672 TTASSTNSGNNSGIGNLRLRTNPDVDVGSGNGSGSGSGSNAGVVNDNGISGGGGSDGASTSSDTG 2736
                     .||.:|
Yeast  1900 ---------KNSALG-------------------------------------------------- 1905

  Fly  2737 APGGARDLNASLLGDVSTSESDSDPSTENDERNEEDEDEDDDAPDEDVDEHSETDVDEERSRQFI 2801
                        :.||                 |:.|::|||......|:.:...||.:..
Yeast  1906 ------------MYDV-----------------EDIEEDDDDDTSLIGDDDAMAFVDSDNG---- 1937

  Fly  2802 EVFDHIYEPESSETASNDADVDNDDDDDEDDVDDDDDDDEDNDDDVREEVQS--VMDAEIENRID 2864
              |:.::.             |.|||..|:|.||...|.|:|  ::..|:||  ....:::..:|
Yeast  1938 --FEVVFS-------------DEDDDMGEEDADDARSDSEEN--ELSSEMQSSTADGTDVDYEVD 1985

  Fly  2865 IALALVSSNNRPRRSAAVNASGDGSANRTNPDDEVDDEDDDVD----ADPDGDPDVDPISGPSAA 2925
            .|..|:.:.::|        |||        |:|:.|.|.::.    ::.:.|..:|.|
Yeast  1986 DADGLIINIDQP--------SGD--------DEEMADYDANISHSSHSENEDDASMDVI------ 2028

  Fly  2926 QAEAYLYERLGSGLMPTPPVGFRVRMNSSIAQPLDIDVNGGNAGSGSNAGATGSSGGSGQRSSTG 2990
              |.| .:.|.|        |:.|.::       |.||:..:..||.::
Yeast  2029 --EVY-DDELSS--------GYDVDLS-------DYDVDESDWDSGLSS---------------- 2059

  Fly  2991 GTTASIGAIASAALRPSSGSWMAPDFNFIRISGGDSSMGSGPAIGGNANGGDMNVFITPSMSLER 3055
                                        :.||..|
Yeast  2060 ----------------------------LSISDED------------------------------ 2066

  Fly  3056 AGGAPGSGQTMSELLNEQPTGAGGGGGGGSASGVGGVGANGGTTGQHPNATLCTNGVRRRLLYLD 3120
                       ||...::|                   .|....|......|...||..
Yeast  2067 -----------SESSEDEP-------------------INSTRMGDSRRRWLIAEGVEL------ 2095

  Fly  3121 QQYCVCMPTHQNPTEETQMETFTQDALHWWLEEATLLDME---SQTDACLYAAHFLLPHLIKELK 3182
                         |:::|.|:...|       ......:|   |..:..|:..|       .|::
Yeast  2096 -------------TDDSQGESEEDD-------RGVFRGIEHIFSNENEPLFRVH-------DEMR 2133

  Fly  3183 AAHQQRKQEEAARQSTTPASGSNASATSSSTTSVVGTAAPTATSSIASGLLANAVSAGSGSSSLV 3247
            ..:..|                          |:..|...:|.|:.:..||    :.|..:.|.:
Yeast  2134 HRNHHR--------------------------SINRTHFHSAMSAPSLSLL----NRGRRNQSNL 2168

  Fly  3248 VPPVAASATGGTRRSSIPVLISSTLGPSSASSATSATGNGATSDATTTTGGPTRNFSSVDSNVSS 3312
            :.|:                                              |||
Yeast  2169 INPL----------------------------------------------GPT------------ 2175

  Fly  3313 ETQTTTRPPRQRGGLRQQSQLPFNIYAEIDLTNEQDSEGDRSTSTTTGTAADGAESQSQHNSSST 3377
                         ||.|                   .|.|.|...|  .|..|:..:|.|
Yeast  2176 -------------GLEQ-------------------VENDISDQVT--VAGSGSRPRSHH----- 2201

  Fly  3378 AAQVAVPQHQRHPPVPLLPSSGRPSRPHTRLDETELLLLQLTDRQIRNRLQGSSGHTNSSRTSGS 3442
                                          |..:|:|:
Yeast  2202 ------------------------------LHFSEVLV--------------------------- 2209

  Fly  3443 ALINARPNRDLPACLQRHDHPAGSIFPRPSANRTPAPTLVSMPTPMSNAALEQ---LNVTAPDVV 3504
                                 :||.|..|..:.....:.||....:.:...:.   .|...|.|:
Yeast  2210 ---------------------SGSFFDEPVLDGIILKSTVSRWKDIFDMFYDSKTYANCIIPTVI 2253

  Fly  3505 RTDRNFALPSSLEVDVDVLPGIVDLPQQEAQPEDDQLLLPPPPPPPPSDTTPLVHAEDDLWPGTV 3569
              :|.:.:..:|:.|:            |.:.|.::|           ....|:..|
Yeast  2254 --NRLYKVSLALQKDL------------ENKREQEKL-----------KNKNLLFNE-------- 2285

  Fly  3570 VSAGTREESSAPAVATESTEAVNESNQPEPTPESSESTSPNPQAPSAEPTPLEPGAAVDASVGAQ 3634
              |.....:|:.|::.|..: :.|||   .|.:..|......|           |:.||  :|.
Yeast  2286 --AKVESHNSSDAISVEQDD-IQESN---VTHDDHEPVYVTIQ-----------GSEVD--IGG- 2330

  Fly  3635 TPATTEEAASTAGASGTTATITDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEVIQEHLRMQ 3699
                                 ||                 :||.|:.|||.::|.:|..:|:|.:
Yeast  2331 ---------------------TD-----------------IDPEFMNALPDDIRADVFAQHVRER 2357

  Fly  3700 RIRQRAQQNAIQIAHDSLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQTANPEDPVDTAAFF 3764
              |..|:.|:....|..  |::.:||.|
Yeast  2358 --RAEARLNSDHNVHSR--EIDSDFLEA------------------------------------- 2381

  Fly  3765 QNLPENLRQAIL-TDMEE----SQIASLPPELAAEAQFLRRDWESRNGARMDAHPPSNALSRFQT 3824
              :||::|:.|| |:.||    .:|.|....:.|:......|.|..||  :| |..||
Yeast  2382 --IPEDIREGILDTEAEEQRMFGRIGSSADVIRADDDVSNNDEEVENG--LD-HGNSN------- 2434

  Fly  3825 TLQSLDDTRWHSSIWYDASGNAQPQHHQHTTIVHQHPHAHHAPNMGKPLALLMMEDENILLDPDS 3889
                             ...||.|:..:...|       :.||                |:|...
Yeast  2435 -----------------DRNNADPEKKKPARI-------YFAP----------------LIDRAG 2459

  Fly  3890 LATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTRDWIISALISIIQKTNEDNANFGAGQAGGKPE 3954
            :|:|:..:|:....:.....|.:...||..:..|:.:::..:.|:.:...|..:
Yeast  2460 IASLMKSVFISKPYIQREIYHELFYRLCSSKQNRNDLMNTFLFILSEGIIDQHS----------- 2513

  Fly  3955 WLKLRVDAAFGYKSNIFLINRLYEGSARSISINPQAAQMIVRNCLDLLFVLAKHYPSSFVPFNRD 4019
                 ::..:.      :|:....|.|::.::                    :..||...|....
Yeast  2514 -----LEKVYN------IISSRAMGHAKTTTV--------------------RQLPSDCTPLTVA 2547

  Fly  4020 VKARRILSAVFGMPSPTAGSGGGAGSGSAASGGLTGYDDVPPGGTLDFRSRFCRYQVVNRLRSIF 4084
            .:...||.::                                   :|..||. :|.::
Yeast  2548 NQTIEILQSL-----------------------------------IDADSRL-KYFLI------- 2569

  Fly  4085 DDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAGSQNKHSVPYQTNAKNFWDVVLNIDQQTQV 4149
                |...::.:::|.:.|:                   |.::|   :.|..|
Yeast  2570 ----AEHDNLIVNKANNKSR-------------------KEALP---DKKLRW------------ 2596

  Fly  4150 RLANVAQFPLTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVICRSPHLTDML-------VKL 4207
                         |.|                  .|..:|..|:|.....|.|:|       .|.
Yeast  2597 -------------PLW------------------HLFSLLDRKLITDESVLMDLLTRILQVCTKT 2630

  Fly  4208 LASLSTELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENTATATEIGDGLAAN 4272
            ||.|||....:|.|
Yeast  2631 LAVLSTSSNGKENL--------------------------------------------------- 2644

  Fly  4273 IEEQASPASGNPASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVIEVLTHQCGT 4337
                                :|:..||                  |.:...|..::.::.....|
Yeast  2645 --------------------SKKFHLP------------------SFDEDDLMKILSIIMLDSCT 2671

  Fly  4338 TEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNIHQGGAGTTS 4402
            |........:|.||::. |...:||.::|.:..:.:..:::.|:..|..|:        |..||.
Yeast  2672 TRVFQQTLNIIYNLSKL-QGCMSIFTKHLVSLAISIMSKLKSALDGLSREV--------GTITTG 2727

  Fly  4403 QAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKK 4467
            ...::......|   :|:...|.||..|...:      |...|......:|.|
Yeast  2728 MEINSELLQKFT---LPSSDQAKLLKILTTVD------FLYTHKRKEEERNVK------------ 2771

  Fly  4468 LMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDM 4532
                               .::.:|:..||
Yeast  2772 -------------------DLQSLYDKMNG----------------------------------- 2782

  Fly  4533 APGSASTISPPPPMETNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVLW 4597
                    .|                                                     :|
Yeast  2783 --------GP-----------------------------------------------------VW 2786

  Fly  4598 NTLSECLVALEESKD-EFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGA 4661
            ::|||||...|:|:. ..:..:|.|.:|:..::
Yeast  2787 SSLSECLSQFEKSQAINTSATILLPLIESLMVV-------------------------------- 2819

  Fly  4662 IGGLGAAAPSAQEYSPFMDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLR 4726
                                               .|..|.|.|        .:||:...:|:|
Yeast  2820 -----------------------------------CRRSDLSQN--------RNTAVKYEDAKL- 2840

  Fly  4727 QDRQK------FLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERL 4785
            .|..|      |..|.:.|:.:|||::|.:| .|..||||:||.:.::||||.||.:|..:|:
Yeast  2841 LDFSKTRVENLFFPFTDAHKKLLNQMIRSNP-KLMSGPFALLVKNPKVLDFDNKRYFFNAKLK-- 2902

  Fly  4786 DEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKN-RFYIVFEDEEGQDAGGLLREWYVIISRE 4849
            .:...|.:..::|||..||.||:|.|:....:|.|| :..|.|:.|.|.||||:.||||.::||:
Yeast  2903 SDNQERPKLPITVRREQVFLDSYRALFFKTNDEIKNSKLEITFKGESGVDAGGVTREWYQVLSRQ 2967

  Fly  4850 IFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHIL 4914
            :|||.||||...|.|:.|:..|.:|..||.|||:|||:|.:|.||:.|...|:|:|:|..||:||
Yeast  2968 MFNPDYALFLPVPSDKTTFHPNRTSGINPEHLSFFKFIGMIIGKAIRDQCFLDCHFSREVYKNIL 3032

  Fly  4915 GKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEEN 4979
            |:.|...||||.|.::||.|.::::|||:.: .|.|||.|..::|..::.:|...|:|..|||.|
Yeast  3033 GRPVSLKDMESLDPDYYKSLVWILENDITDI-IEETFSVETDDYGEHKVINLIEGGKDIIVTEAN 3096

  Fly  4980 KFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTE 5044
            |.:||:.|.:.|:..|:::|:|.||.|||.:|.|.||:||:|||||||||||||||::|.|.||.
Yeast  3097 KQDYVKKVVEYKLQTSVKEQMDNFLVGFYALISKDLITIFDEQELELLISGLPDIDVDDWKNNTT 3161

  Fly  5045 YHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRST 5109
            |..||:...::.:||||:||||..:|||.||||||||||||.||..|.|:||:.||.||||..|:
Yeast  3162 YVNYTATCKEVSYFWRAVRSFDAEERAKLLQFVTGTSKVPLNGFKELSGVNGVCKFSIHRDFGSS 3226

  Fly  5110 DRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFGFA 5151
            :|||.:|||||||:||.|:||:.||..||.||:|..||||.|
Yeast  3227 ERLPSSHTCFNQLNLPPYESYETLRGSLLLAINEGHEGFGLA 3268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630	55/247 (22%)
		DUF913	621..989	CDD:283642	72/378 (19%)
		UBA_like_SF	1467..1506	CDD:304366	7/38 (18%)
		WWE	1756..1828	CDD:128922	4/71 (6%)
		40S_SA_C	3575..3651	CDD:292740	13/75 (17%)
		DUF4414	3675..3779	CDD:291075	24/104 (23%)
		HECTc	4796..5149	CDD:238033	186/353 (53%)
		HECTc	4820..5148	CDD:214523	175/328 (53%)
TOM1	NP_010745.3	DUF908	92..387	CDD:399185	74/364 (20%)
		DUF913	448..>683	CDD:399192	67/327 (20%)
		MSCRAMM_ClfB	<1879..2061	CDD:411414	61/480 (13%)
		DUF4414	2328..2357	CDD:405126	13/67 (19%)
		HUL4	2385..3268	CDD:227354	337/1400 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344332
Domainoid	1	1.000	336	1.000	Domainoid score	I166
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7112
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto99102
orthoMCL	1	0.900	-	-		OOG6_101783
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3469
TreeFam	1	0.960	-	-
	11	10.650