Protein Alignment HUWE1 and UPL2

DIOPT Version :9

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_177189.1
• Gene: UPL2 / 843368
• AraportID: AT1G70320
• Length: 3658
• Species: Arabidopsis thaliana
• Alignment Length: 5425
• Identity: 1115/5425 - (20%)
• Similarity: 1835/5425 - (33%)
• Gaps: 2053/5425 - (37%)

  Fly     9 KKGSSELTAECRELIDELTKRRTRAELLEFLDTVHVWIYGKCELYHWIEILDRFDKILEEASRHV 73
            ::.:||:..:....|:.:|.  ...||::.......|.:.|.:.:||:::...||...|   :||
plant     5 RRRASEVPTKISLFINSVTS--VPLELIQEPLASFRWEFDKGDFHHWVDLFYHFDTFFE---KHV 64

  Fly    74 NGNEFVLQCDTNFQETDVTL----LLHVLNFTTLLIEHSFSRHLYNSIE-HLTVLLSSQNMDIVL 133
            ...: .|:.:..|.|:|...    :|.||....|::|:..::..|.|.| ||::||:|.:.|:|.
plant    65 KVRK-DLRIEEEFDESDPPFPKDAVLQVLRVIRLVLENCTNKQFYTSYEQHLSLLLASTDADVVE 128

  Fly   134 AVLNLLYMFSKRSNFIPRLPFEKKEL----LIVKLFNIAERWGDPNYGLSLKDCCIGEPKLEFLY 194
            |.|..|..|.||       |..|..:    |.:|||::|:.||....||.|..|.......:...
plant   129 ACLQTLAAFLKR-------PTGKYSIRDASLNLKLFSLAQGWGGKEEGLGLTSCATEHSCDQLFL 186

  Fly   195 QLCIDYVDEH--GHAAQLEIPDMMDLCHTASAPEVI-----------KTIAGQISKPSEAIKMRI 246
            ||....:.|.  ...:..|:|..:.:.|   .|:|.           |.:......||  ::..:
plant   187 QLGCTLLFEFYASDESPSELPGGLQVIH---VPDVSMRSESDLELLNKLVIDHNVPPS--LRFAL 246

  Fly   247 AHRVRLISGFNNYKLRLQFVQARLQAVSILIYSNALQDNTDKVLYAGFGE-----ELCELIDKED 306
            ..|:|....|::...|.|:...||.|..:|:.::.   :|:.|:....||     ||..|:..||
plant   247 LTRLRFARAFSSLATRQQYTCIRLYAFIVLVQASG---DTENVVSFFNGEPEFVNELVTLVSYED 308

  Fly   307 VHLVEIRAAVLRTLTSMLH-FDRNPNVPRAGSRLMKIVHYTGAERQGGTLPLLVRDCIDNLTTHG 370
            ....:||...|::|.::.. ..|.|.|..|.:        :|..|  |.|..|::..||::..:
plant   309 TVPAKIRILCLQSLVALSQDRTRQPTVLTAVT--------SGGHR--GLLSGLMQKAIDSVICN- 362

  Fly   371 LTERYPLILATSLFSLLYHLASYEMGGTALVKSGMMQSLLCVISWPGVDLEHITFVTRAVRVIDL 435
             |.::.|..|.:|.||:..|.|...|.:|:.::|::.:|:.:|.  ..|.:|:..|:.||.::::
plant   363 -TSKWSLAFAEALLSLVTVLVSSSSGCSAMREAGLIPTLVPLIK--DTDPQHLHLVSTAVHILEV 424

  Fly   436 I---TNIDIARFHQNNGLNVFIDRLEKEIKSCCKALADIGITLKESTLRDDHKLDTSLDHVDEDV 497
            .   :|...|.|....||:..|.||::|:                             ...::||
plant   425 FMDYSNPAAALFRDLGGLDDTIFRLKQEV-----------------------------SRTEDDV 460

  Fly   498 EDGSGENASVTSGNASPRRDNSSDGATGAGSIVYRAYHEHIGGAGSGAGLLDIGGARSSLSGGSS 562
            ::     ....||:..|..|
plant   461 KE-----IVCCSGSNGPEDD--------------------------------------------- 475

  Fly   563 GTSGMGAGSINRDGSAARPPAIMYPTNSYYARPLAERKAELSSQLPSSLAPKKPSCVTQRAALLK 627
                                                     :.|||.|.|    .....|..|||
plant   476 -----------------------------------------TEQLPYSEA----LISYHRRLLLK 495

  Fly   628 SMLNFLKKSIQDHA-HFSNMRNIMETSLTQSLRHIIANAEYYGPSLFLLATDVVTVYVFNEPSLL 691
            ::|..:  |:..:| ..:|:....|:.|.:.|..|...|:.:|..:|.||..|::..:..:|:..
plant   496 ALLRAI--SLGTYAPGNTNLYGSEESLLPECLCIIFRRAKDFGGGVFSLAATVMSDLIHKDPTCF 558

  Fly   692 SSLQDLGITSVMLKALLQKDVPATREVLGSLPNVFSALCLNERGLFEFLSYDPFDKVLKVLLSPD 756
            ::|...|:||..|.| :..:|..:.|.:..:|....|||||..||......:.....:|:..||.
plant   559 NALDSAGLTSAFLDA-ISDEVICSAEAITCIPQCLDALCLNNSGLQAVKDRNALRCFVKIFSSPS 622

  Fly   757 YLVAMRRRRSSDPLGDTATNLGNAMDDLIKHHPYLRADATEAIVRLLNELVRLGSDPSFICWRAN 821
            ||.|:        ..||..:|.:.:|:|::|...||....:..:.:||.::.:||         .
plant   623 YLKAL--------TSDTPGSLSSGLDELLRHQSSLRTYGVDMFIEILNSILIIGS---------G 670

  Fly   822 KESSGSGSGSGSHGGGHHVASTPSPMVMVAGTGSASSVLQGAADTNDSSGDDDDDDDEMSSASQQ 886
            .|::.|.|..        |.:..:|:.|                        :.|.||.|.|...
plant   671 MEATTSKSAD--------VPTDAAPVPM------------------------EIDVDEKSLAVSD 703

  Fly   887 QQQPTTPGQGGGPSTPRTQQAGGVVGSGAGATGTPAAASQAVKVVTPPEREAIPLIDYILNVMKF 951
            :.:|::.                                      |.|....:.|.|.:.||.:.
plant   704 EAEPSSD--------------------------------------TSPANIELFLPDCVCNVARL 730

  Fly   952 IEAIFSNSPNGDHCREFVLHGGLKPILQLLSLPNLPVDSPV---------STTSQAVANVCKAIL 1007
            .|.:..|:   :.|..||...|:..:|||.|||.:|:.:.:         :.:.|..|.:.:.:.
plant   731 FETVLQNA---EVCSLFVEKKGIDTVLQLFSLPLMPLSTSLGQSFSVAFKNFSPQHSAGLARILC 792

  Fly  1008 SQAQETKVLDVALKQLADIVAQLKPLIKHFTFPGGSVLLAELVCCQRLEDGFANAEYTPILHNMS 1072
            |..:|      .||:..:::..::          |:.||       :||    :|..|.||.::|
plant   793 SYLRE------HLKKTNNLLVSIE----------GTQLL-------KLE----SAVQTKILRSLS 830

  Fly  1073 FVHGYVVMLVHLCRNASNDMRTILLKRWGVNRETGVQLLQQLVQLYISLVWESTILLNLCSDEPT 1137
            .:.|.:.:...|.:.:::.:..:......|.:|.|:        .|...:|:    :.||:|...
plant   831 CLEGMLSLSNFLLKGSASVISELSAANADVLKELGI--------TYKQTIWQ----MALCNDTKE 883

  Fly  1138 QHPDLIWDEIAAQMSAAAGTADPLTEAELSRKLE---------RAAEFRTKYTPEEQF-RYIKSL 1192
            .....:.......:||::.||:..::.:.|..|.         |::..::.:....:| ..::|.
plant   884 DEKKSVDRASDNSVSASSSTAERESDEDSSNALAVRYTNPVSIRSSSSQSIWGGHREFLSVVRSG 948

  Fly  1193 LAASSRLGRALAELLGTLVKLSVGSPQTRQRRINDLISNITKVP-----TPEAREIARILSSILV 1252
            .........|:|.:.|           .|.||..:..:..:::|     |..:.|:.:..:.:|:
plant   949 RGVHGHTRHAIARMRG-----------GRTRRHLESFNFDSEIPADLPVTSSSHELKKKSTEVLI 1002

  Fly  1253 NGFSHESILPKPVPKLKLTFLICSVGFT--------GPML------------------------- 1284
                 ..||.|....|:..|.....|||        ||.|
plant  1003 -----AEILNKLNCTLRFFFTSLVKGFTSANRRRIDGPSLSSASKTLGTALAKVFLEALNFQGYG 1062

  Fly  1285 ---------------------------FDDKRS-AFHLMISQFCAENGLKAFFEMFYWALSLDNV 1321
                                       ||.:|. .|..|::.|......|.....|      :..
plant  1063 AAAGPDTSLSLKCRYLGKVVDDITFLTFDTRRRVCFTAMVNSFYVHGTFKELLTTF------EAT 1121

  Fly  1322 SQ---KFEFDQWASMEDLMQSHEDDKRDCPEGTGEFLDAWLQLLEKMVNPRAMLDSPYTMSP--- 1380
            ||   |..|...||..:..:|.|.:.....:...:.|..:.:.|:..||      |.|.:||
plant  1122 SQLLWKVPFSIRASSTENEKSGERNLWSHSKWLVDTLQNYCRALDYFVN------STYLLSPTSQ 1180

  Fly  1381 -RLNYMPDS---------VPFEPVFYLIHIHQLAMQALRRIWARRPIPNYGPSMFETMILILKHL 1435
             :|...|.|         ||.||..::.::....::.:..||.....|:..|:...::..::.|:
plant  1181 TQLLVQPASVDLSIGLFPVPREPETFVRNLQSQVLEVILPIWNHPMFPDCNPNFVASVTSLVTHI 1245

  Fly  1436 IKSHQTLLDRYHTRMKEIKFEN---LYIRSTDDGLNADHIKTLTDMGFMHYHVIEALR---TNAS 1494
               :..::|....|....:..|   |.:: .|:.:    :..:.:|||......:|||   || |
plant  1246 ---YSGVVDTRENRSGATQGTNQRALPLQ-PDEAI----VGMIVEMGFSRSRAEDALRRVGTN-S 1301

  Fly  1495 LEEATDYLLNNPE---------ASSLSTTGGQSSSSAPPPPPPPSASTMDIDVDVPADGESTQSK 1550
            :|.|.|:|..|||         |.:|:.:.|.||.:       |.....:..||||.:    :::
plant  1302 VEMAMDWLFTNPEDPVQEDDELAQALALSLGNSSET-------PKLEDTEKPVDVPQE----EAE 1355

  Fly  1551 SSTSPNSSYDYKHLKLMPSLIFDRFCDEAISRAFEFMEAIPDTVNSAADLIAVLYRRHNHLNKQV 1615
            ....|                    .||.|:.:.:..::.........||...|..|:...::..
plant  1356 PKEPP--------------------VDEVIAASVKLFQSDDSIAFPLVDLFVTLCNRNKGEDRPK 1400

  Fly  1616 FVTNFVRNI-IQWVDFTLQLFEPAKTTGSKASRLEECLTGMTATRLFVRLKTSTLLLEENYSDLH 1679
            .|...::.: :..:||       :|.||              |..:...:....|..::|
plant  1401 IVFYLIQQLKLVQLDF-------SKDTG--------------ALTMIPHILALVLSEDDN----- 1439

  Fly  1680 RPLVEAITAQDAMVSLVKLLDCMSQWMLEQSTETNTGQQRATVPRWVQNLVDLIDAIDSISHILQ 1744
               ...|.|||.:|::.  :..::.:.|:..:||:     ...|:.:..|: |:     :|.:||
plant  1440 ---TREIAAQDGIVAVA--IGILTDFNLKSESETD-----ILAPKCISALL-LV-----LSMMLQ 1488

  Fly  1745 RKANMRAVSSDVWRWYDASTGKWNAYSEANNELIRNAYAAGERWLYINIGRQRCTVSLNCMTQVS 1809
            .:..:   ||:              |.|.|
plant  1489 AQTRL---SSE--------------YVEGN----------------------------------- 1501

  Fly  1810 EASGTHRPVCPALKLSEAITSLNNPVALHKVEHILNRVVRTAPDGSGTVHSDELISLRQLVNFTD 1874
                                                       .|...|.||
plant  1502 -------------------------------------------QGGSLVLSD------------- 1510

  Fly  1875 GQQPQQSENSANPSEEATSEDGPAAANSGSPPATMTTRSKTRQKSAAAAAAAKNKSQSGGSPPIP 1939
              .||               |..||.                 |.|.::..||.:|.........
plant  1511 --SPQ---------------DSTAAL-----------------KDALSSDVAKGESNQALESMFG 1541

  Fly  1940 KRTQKIILNEEQVGLSKFDCGRIIGSIVDLLQPSHQMLNETKLSLLRLCARLTRNYDNAQVFIRR 2004
            |.|..:.: ||...:....||.|...:..::..          ::|:||||||:::..|..|:..
plant  1542 KSTGYLTM-EESSKVLLIACGLIKQRVPAMIMQ----------AVLQLCARLTKSHALAIQFLEN 1595

  Fly  2005 GGVRMLLHLQQACSFMGFPTYANIILRHVLEAPPVLQEAMERVLGMRAAGIVPVGHRDLIYVLTQ 2069
            ||:..|.:|.:.|.|.|:.|.|::|:||::|.|..||.|||..:....:|...:|.......||.
plant  1596 GGLSSLFNLPKKCFFPGYDTVASVIVRHLVEDPQTLQIAMETEIRQTLSGKRHIGRVLPRTFLTT 1660

  Fly  2070 VSSAVSRNPQIFVAAAKEMLKGEYLINTNSTTLADDARVMVKSKFGQQPTAAAGGATPHNQTPTP 2134
            ::..:||:|.:|:.|.....:   |.::..|    |..::.|.|  ::|..:   .:.|..:...
plant  1661 MAPVISRDPVVFMKAVASTCQ---LESSGGT----DFVILTKEK--EKPKVS---GSEHGFSLNE 1713

  Fly  2135 PPAAKDELKDDPQVQSS----------VAVLKELLHGLVQPCWHYGGTGSLDRGQG-AAELLQPD 2188
            |....:....|...:.|          :.|:.:|:..::.    :.|   |.|.:| ||.|:..|
plant  1714 PLGISENKLHDGSGKCSKSHRRVPTNFIQVIDQLIDIVLS----FPG---LKRQEGEAANLISMD 1771

  Fly  2189 QPPGTAQGCHDDELYFRFQETPAPVSSKKQSSSGGGAAAAGQTGQA---TEKFEPCCCTWHIPTS 2250
            .          ||          |.:..|      |.:..|:..:|   :||.|
plant  1772 V----------DE----------PTTKVK------GKSKVGEPEKAELGSEKSE----------- 1799

  Fly  2251 GHTHAKPTISRAT-LLKLLADSTRAYQSLVPRVL--------LSHVYTPADSP----LISAPQQT 2302
                   .::|.| :||||:|....|......:|        |.....|.|||    ||......
plant  1800 -------ELARVTFILKLLSDIVLMYLHGTSVILRRDTEISQLRGSNLPDDSPGNGGLIYHVIHR 1857

  Fly  2303 FLGVLLDRFL-PITQRHHVPEVSTMTRVLICSLSDCYQQPGVQVHVAEELHAAVARALAQPDSAE 2366
            .|.:.|::|: |...:..:.|.::...|::||.|:..::     .:..||
plant  1858 LLPISLEKFVGPEEWKEKLSEKASWFLVVLCSRSNEGRK-----RIINEL--------------- 1902

  Fly  2367 KHTR-LQVLMSLFPNLIESPMLYDK-VHMHRNNMYRVLLRQ----------------------GV 2407
              || |.|..||..:..:|.:|.|| |....|.:|.:|.:.                      |.
plant  1903 --TRVLSVFASLGRSSSQSVLLPDKRVLAFANLVYSILTKNSSSSNFPGCGCSPDVAKSMIDGGT 1965

  Fly  2408 MTYLTKVAQYKDLSNHNTLSTLAAILRPMEILLRFSVSTTTLGSKRILFGSGGPGGPNASGNGNN 2472
            :..||.:....||.:.:....:..||:.:|.|.|.:.:...|.|:          .||..
plant  1966 IQCLTSILNVIDLDHPDAPKLVTLILKSLETLTRAANAAEQLKSE----------VPNEQ----- 2015

  Fly  2473 TAGGSSGNGPGSGNTYGTIINRRLYPRLAARTGFGSAMERSNAMGGEHVLRDIIRNVLSDRRHAF 2537
                                                                  :|..||.||
plant  2016 ------------------------------------------------------KNTDSDERH-- 2024

  Fly  2538 EFIFNSDDMAVDSEDAAAPGSGVGGGGSGAGSVGGGVSGSVSGNSSAAVIDVVEERSNGGDTNDP 2602
                       ||.                            |.|::..:|.:
plant  2025 -----------DSH----------------------------GTSTSTEVDEL------------ 2038

  Fly  2603 PANVSSASSGAGQSSTSGGPVRPVVNFDQLWDDFLQSEGLRLASRSGGGAGSGSGSVGASSSGQQ 2667
              |.:::|......:...|..:|.|:        .||||.|
plant  2039 --NQNNSSLQQVTDAVDNGQEQPQVS--------SQSEGER------------------------ 2069

  Fly  2668 NGSNTTASSTNSGNNSGIGNLRLRTNPDVDVGSGNGSGSGSGSNAGVVNDNGISGGGGSDGASTS 2732
                                                   ||.....::.:..|.|
plant  2070 ---------------------------------------GSSLTQAMLQEMRIEG---------- 2085

  Fly  2733 SDTGAPGGAR--DLNASLLGD-VSTSESDSDPSTENDERNEEDEDEDDDAPDEDVDEHSE----- 2789
            .:|..|...:  .....:.|| :..|....|.:.::.:.:.:||.|||:..|||.|...:
plant  2086 DETILPEPIQMDFFREEIEGDQIEMSFHVEDRADDDVDDDMDDEGEDDEGDDEDADSVEDGAGVM 2150

  Fly  2790 ----TDVDEERSRQFIEVFDHIYEPESSETAS--NDADVDNDDDDDE---DDVDDDDDDDED--N 2843
                |||:               :||.:....  ||..||.|::|::   ||:.|:|:||||  |
plant  2151 SIAGTDVE---------------DPEDTGLGDEYNDDMVDEDEEDEDEYNDDMVDEDEDDEDEYN 2200

  Fly  2844 DDDVREEVQSVMDAE-IENRIDIALALVSSNNRPRRSAAVNASGDGSANRTNPDDEVDDEDDDVD 2907
            ||.|.|:.....:.. ||.|...||..:.      ....|..||.|:.           ..||:.
plant  2201 DDMVDEDEDDFHETRVIEVRWREALDGLD------HFQIVGRSGGGNG-----------FIDDIT 2248

  Fly  2908 ADPDGDPDVDPISGPSAAQAEAYLYERLGSGLMPTPPVGFRVRMNSSIAQPLDIDVNGGNAGSGS 2972
            |:|....:||          :.:...|         .:||..|..:           |.::...|
plant  2249 AEPFEGVNVD----------DLFALRR---------SLGFERRRQT-----------GRSSFDRS 2283

  Fly  2973 NAGATGSSGGSGQRSSTGGTTASIGAIASAALRPS-SGSWMAPDFNFIRISGGDSSMGSGPAIGG 3036
            .:...|.......|.|..|.|||:.|.|.:..|.| :||:....|
plant  2284 GSEVHGFQHPLFSRPSQTGNTASVSASAGSISRHSEAGSYDVAQF-------------------- 2328

  Fly  3037 NANGGDMNVFITPSMSLERAGGAPGSGQTMSELLNEQPTGAGGGGGG----------GSASGVGG 3091
                   .:|.:|.:..::....|.|.:.             ||||.          |..|...|
plant  2329 -------YMFDSPVLPFDQVPVDPFSDRL-------------GGGGAPPPLTDYSVVGMDSSRRG 2373

  Fly  3092 VGANGGTTGQHPNATLCTNGVRRRLLYLDQQYCVCMPTHQNPTEETQMETFTQDALHWWLEEATL 3156
            ||.:..|...||..:..:..:
plant  2374 VGDSRWTDVGHPQPSSLSASI-------------------------------------------- 2394

  Fly  3157 LDMESQTDACLYAAHFLLPHLIKELKAAHQQRKQEEAARQSTTPASGSNASATSSSTTSVVGTAA 3221
                         |..:..|.|..|:|                                    :|
plant  2395 -------------AQLIEEHFITNLRA------------------------------------SA 2410

  Fly  3222 PTATSSIASGLLANAVSAGSGSSSLVVPPVAASATGGTRRSSIPVLISSTLGPSSASSATSATGN 3286
            |
plant  2411 P---------------------------------------------------------------- 2411

  Fly  3287 GATSDATTTTGGPTRNFSSVDSNVSSETQTTTRPPRQRGGLRQQSQLPFNIYAEIDLTNEQDSEG 3351
                               ||:.|..||.||....      :||..:|.::.:|
plant  2412 -------------------VDTVVERETNTTEVQE------QQQPDVPPSVGSE----------- 2440

  Fly  3352 DRSTSTTTGTAADGAESQSQHNSSSTAAQVAVPQHQRHPPVPLLPSSGRPSRPHTRLDETELLLL 3416
                 |..|...:|.|...:|                                       |||
plant  2441 -----TVLGDGNEGGEQSEEH---------------------------------------ELL-- 2459

  Fly  3417 QLTDRQIRNRLQGSSGHTNSSRTSGSALINARPNRDLPACLQRHDHPAGSIFPRPSANRTPAPTL 3481
                              |::.......:|:.||.     :.|.:...|...|....:|.....:
plant  2460 ------------------NNNEVMHPLPLNSTPNE-----IDRMEVGEGGGAPIEQVDREAVHLI 2501

  Fly  3482 VSMPTPMSNAALEQLNVTAPDVVRTDRNFALPSSLEVDVDVLPGIVDLPQQEAQPEDDQLLLPPP 3546
            .|.......:.::.::|||                                          :|||
plant  2502 SSAQGQSDTSGIQNVSVTA------------------------------------------IPPP 2524

  Fly  3547 PPPPPSDTTPLVHAEDDLWPGTVVSAGTREESSAPAVATESTEAVNESNQPEPTPESSESTSPNP 3611
            ...|.|:..|.|..:       :.|.|.                  |.||
plant  2525 VDDPDSNFQPSVDVD-------MSSDGA------------------EGNQ--------------- 2549

  Fly  3612 QAPSAEPTPLEPGAAVDASVGAQTPATTEEAASTAGASGTTATITDMSPEVRAALGDLEVPEGVD 3676
               |.:|:||:......:|:.|......:|........|       .:|||.|          :|
plant  2550 ---SVQPSPLDGDNNELSSMEATQDVRNDEQVDEGSLDG-------RAPEVNA----------ID 2594

  Fly  3677 PSFLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQ---IAHDSLVEVNPEFLAALPLNIQSEVLM 3738
            |:||.|||.::|.||:..        |:||  ::|   ....|:.:::||||||||..||.|||.
plant  2595 PTFLEALPEDLRAEVLAS--------QQAQ--SVQPPTYEPPSVDDIDPEFLAALPPEIQREVLA 2649

  Fly  3739 QQRIEQQRQAAQTANPEDPVDTAAFFQNLPENLRQAILTDMEESQIASLPPELAAEAQFLR---- 3799
            |||.::..|.:| ..|.| :|.|:....||.:||:.:|....|:.:|:|||.|.||||.||
plant  2650 QQRAQRMLQQSQ-GQPVD-MDNASIIATLPADLREEVLLTSSEAVLAALPPPLLAEAQMLRDRAM 2712

  Fly  3800 RDWESRNGARMDAHPPSNALSRFQTTLQSLDDTRWHSSIWYDASGNAQPQHHQHTTIVHQHPHAH 3864
            |.:::|:.....:|..:|..:.....|..::.....:....|.|.:|.
plant  2713 RHYQARSRVFGSSHRLNNRRNGLGYRLTGMERGVGVTIGQRDVSSSAD----------------- 2760

  Fly  3865 HAPNMGKPLALLMMEDE-NILLDPDSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTRDWIIS 3928
                     .|.:.|.| :.|::.|:|.:|:..|.:. |.:....|.|::.|||.|..||..::.
plant  2761 ---------GLKVKEIEGDPLVNADALKSLIRLLRLA-QPLGKGLLQRLLLNLCAHSFTRANLVQ 2815

  Fly  3929 ALISIIQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGYKSNIFLIN--RLYEGSARSISINPQAA 3991
            .|:.:|                 :||...|        .|.:.|.|  |||
plant  2816 LLLDMI-----------------RPEMETL--------PSELALTNPQRLY-------------- 2841

  Fly  3992 QMIVRNCLDLLFVLAKHYPSSFVPFNRDVKARRILSAVFGMPSPTAGSGGGAGSGSAASGGLTGY 4056
                 .|.                          |:.|:|.              |....||
plant  2842 -----GCQ--------------------------LNVVYGR--------------SQLLNGL--- 2858

  Fly  4057 DDVPPGGTLDFRSRFCRYQVVNRLRSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAGS 4121
               ||   |.||      :|:..|..:..:|.|....:...::...|:.::.|
plant  2859 ---PP---LVFR------RVLEVLTYLATNHSAVADMLFYFDSSLLSQLSSRK------------ 2899

  Fly  4122 QNKHSVPYQTNAKNFWDVVLNIDQQTQVRLANVAQFPLTSQPAWEWQPNTADFLSFSESPFGQLL 4186
             .|..|.::|::::.                   :.||..            ||.....|  |||
plant  2900 -GKEKVTHETDSRDL-------------------EIPLVV------------FLKLLNRP--QLL 2930

  Fly  4187 EMLPYKVICRSPHLTDMLVKLLASLSTELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPP 4251
            :        .:.||..::..|...:.|...:.|...| |..:|..:...||
plant  2931 Q--------STSHLALVMGLLQVVVYTAASRIEGWSP-SSGVPEKLENKPV-------------- 2972

  Fly  4252 PQPPAENTATATEIGDGLAANIEEQASPASGNPASGDSNAGAKRTQLPTLSVALPVTPSKPRRKI 4316
                                          |..||.::...|:    ..||||        ||
plant  2973 ------------------------------GEEASSETQKDAE----SELSVA--------RR-- 2993

  Fly  4317 YSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQY--LTAAILGLAEEVRQ 4379
              ||.::|.                    .:.:.|.|....:..:.:.|  |:..|..||.||
plant  2994 --KNCAELY--------------------NIFLQLPQSDLCNLCMLLGYEGLSDKIYSLAGEV-- 3034

  Fly  4380 AIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAE 4444
                 |.::...::......|...:...||.:::|...:.|:|
plant  3035 -----LKKLAAVDVTHRKFFTKELSELASGLSSSTVRVLATLS---------------------- 3072

  Fly  4445 HVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAG 4509
                :..|.::.||             |.|....||.|::...:
plant  3073 ----TTQKMSQNTC-------------SMAGASILRVLQVLSSL--------------------- 3099

  Fly  4510 DNDDDIIDIEGDGGASGGSSSDMAPGSASTISPPPPMETNQIAQDGDDDEEDDDEARSFPGVGNH 4574
                                       .|||.     ::|.    |.|.|.|.:|.....|:.
plant  3100 ---------------------------TSTID-----DSNV----GTDKETDQEEQNIMQGLK-- 3126

  Fly  4575 AVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEFA----------VLVLQPT------- 4622
                            :.|:.||..|.:|:...|...|..|          ||.:.||
plant  3127 ----------------VALEPLWQELGQCISMTELQLDHTAATSNVNPGDHVLGISPTSSLSPGT 3175

  Fly  4623 ------VEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSPFMDD 4681
                  :||||::
plant  3176 QSLLPLIEAFFVL---------------------------------------------------- 3188

  Fly  4682 VSSANTPSSASFDDEPRMQDASTNTPLVTNPST--STAMSAHEAQLRQDRQ-KFLQFAEKHRTVL 4743
            .....|||..       .|||:.....|...||  |::.:..::|.:.|.. .|.:|.||||.:|
plant  3189 CEKIQTPSML-------QQDATVTAGEVKESSTHGSSSKTIVDSQKKIDGSVTFSKFVEKHRRLL 3246

  Fly  4744 NQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERLDEGIRREEH-----TVSVRRVTV 4803
            |..:||:|: |.:..|::::...|::|||.|:.||::.:..     :.::|     .:||||..|
plant  3247 NSFVRQNPS-LLEKSFSMMLKAPRLIDFDNKKAYFRSRIRH-----QHDQHISGPLRISVRRAYV 3305

  Fly  4804 FEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTY 4868
            .|||:..|....|::.|.|..:.|:.|||.|||||.||||.::||.||:....|| .:.|:..|:
plant  3306 LEDSYNQLRMRSPQDLKGRLNVQFQGEEGIDAGGLTREWYQLLSRVIFDKGALLF-TTVGNDATF 3369

  Fly  4869 MINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKG 4933
            ..||:|.....||||||||||::|||:.|.:||:.||||||||||||.:|.:.|:|:.|.::||.
plant  3370 QPNPNSVYQTEHLSYFKFVGRMVAKALFDGQLLDVYFTRSFYKHILGVKVTYHDIEAVDPDYYKN 3434

  Fly  4934 LDYLMKNDISTLGYELTFSTEVQE-----FGVTQIRD--LKPNGRDTAVTEENKFEYVQLVCQLK 4991
            |.:|::||:|.: .:||||.:..|     :..|::.|  |||.||:..||||.|.|||.||....
plant  3435 LKWLLENDVSDI-LDLTFSMDADEEKHILYEKTEVTDYELKPGGRNIRVTEETKHEYVDLVADHI 3498

  Fly  4992 MSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQ 5056
            ::.:||.|::|||||..::||:.|:||||::||||||||||:||.:||||||||..||..|..|:
plant  3499 LTSAIRPQINAFLEGLNELIPRELVSIFNDKELELLISGLPEIDFDDLKANTEYTSYTVGSPVIR 3563

  Fly  5057 WFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQ 5121
            |||..:::|.:.|.|:|||||||||||||:||.:|:|::|.|:.|||:...|.:|||.|||||||
plant  3564 WFWEVVKAFSKEDMARFLQFVTGTSKVPLEGFKALQGISGPQRLQIHKAYGSPERLPSAHTCFNQ 3628

  Fly  5122 LDLPMYKSYDKLRSCLLKAIHECSEGFGFA 5151
            ||||.|:|.::::..||.||||.:||||||
plant  3629 LDLPEYQSKEQVQERLLLAIHEANEGFGFA 3658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630	68/263 (26%)
		DUF913	621..989	CDD:283642	84/368 (23%)
		UBA_like_SF	1467..1506	CDD:304366	13/41 (32%)
		WWE	1756..1828	CDD:128922	3/71 (4%)
		40S_SA_C	3575..3651	CDD:292740	10/75 (13%)
		DUF4414	3675..3779	CDD:291075	42/106 (40%)
		HECTc	4796..5149	CDD:238033	189/359 (53%)
		HECTc	4820..5148	CDD:214523	178/334 (53%)
UPL2	NP_177189.1	DUF908	88..358	CDD:283630	77/294 (26%)
		DUF913	416..765	CDD:283642	106/565 (19%)
		UBA_atUPL1_2_like	1275..1312	CDD:270512	13/41 (32%)
		DUF4414	2593..2688	CDD:291075	42/106 (40%)
		HECTc	3296..3656	CDD:238033	189/361 (52%)
		HECTc	3320..3655	CDD:214523	178/336 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	330	1.000	Domainoid score	I261
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	879	1.000	Inparanoid score	I59
OMA	1	1.010	-	-		QHG55621
OrthoDB	1	1.010	-	-		D25515at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3148
orthoMCL	1	0.900	-	-		OOG6_101783
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3469
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.840