| Sequence 1: | NP_001285288.1 | Gene: | HUWE1 / 32510 | FlyBaseID: | FBgn0030674 | Length: | 5151 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001244066.1 | Gene: | ITCH / 83737 | HGNCID: | 13890 | Length: | 903 | Species: | Homo sapiens |
| Alignment Length: | 865 | Identity: | 252/865 - (29%) |
|---|---|---|---|
| Similarity: | 395/865 - (45%) | Gaps: | 144/865 - (16%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 4324 LQLVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEI 4388
Fly 4389 RMYNIHQGGAGTTSQAASTSGAAAATASYVPT----------------VSGASLLPNLAVHEGIM 4437
Fly 4438 QDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGG 4502
Fly 4503 GVACGAGDNDDD------IIDIEGDGGASGGSSSDMAPGSASTISPPPPMETNQIAQDGDDDEED 4561
Fly 4562 DDEARSF--------PG----VGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEF 4614
Fly 4615 AVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFG---LRAAAGAGAIGGLGAAAPSAQEYS 4676
Fly 4677 PFMDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRT 4741
Fly 4742 VLNQI-LRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERLDEGIRREEH-TVSVRRVTVF 4804
Fly 4805 EDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYM 4869
Fly 4870 INPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGL 4934
Fly 4935 DYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQ 4999
Fly 5000 LDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRS 5064
Fly 5065 FDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKS 5129
Fly 5130 YDKLRSCLLKAIHECSEGFG 5149 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| HUWE1 | NP_001285288.1 | DUF908 | 90..326 | CDD:283630 | |
| DUF913 | 621..989 | CDD:283642 | |||
| UBA_like_SF | 1467..1506 | CDD:304366 | |||
| WWE | 1756..1828 | CDD:128922 | |||
| 40S_SA_C | 3575..3651 | CDD:292740 | |||
| DUF4414 | 3675..3779 | CDD:291075 | |||
| HECTc | 4796..5149 | CDD:238033 | 152/352 (43%) | ||
| HECTc | 4820..5148 | CDD:214523 | 142/327 (43%) | ||
| ITCH | NP_001244066.1 | C2_E3_ubiquitin_ligase | 17..140 | CDD:175988 | |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 197..301 | 21/132 (16%) | |||
| WW | 328..357 | CDD:306827 | 7/28 (25%) | ||
| HUL4 | <359..903 | CDD:227354 | 198/593 (33%) | ||
| Required for interaction with FYN. /evidence=ECO:0000269|PubMed:16387660 | 395..471 | 14/90 (16%) | |||
| MAP kinase docking site. /evidence=ECO:0000250 | 574..583 | 2/8 (25%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||