DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and MAGIX

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_079135.3	Gene:	MAGIX / 79917	HGNCID:	30006	Length:	334	Species:	Homo sapiens

Alignment Length:	401	Identity:	82/401 - (20%)
Similarity:	125/401 - (31%)	Gaps:	143/401 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1833 NPVALHKVEHILNRV------VRTAPDGSGTV-HSDELISLRQL----------VNFTDGQQPQQ 1880
            :|:|......:|.|:      .|.|.|.:..| .:...:.||:.          :..||.:.|..
Human    21 SPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHA 85

  Fly  1881 SENSANPSEEATSEDGPAAANSGSPPATMTTRSKTRQKSAAAAAAAKNKSQSG------------ 1933
            :.....|......       ...:||..:..::::..|.:.|:.....:...|
Human    86 TIVDHRPQHRWLE-------TCNAPPQLIQGKARSAPKPSQASGHFSVELVRGYAGFGLTLGGGR 143

  Fly  1934 ---GSPPIPKRTQKIILNEEQVGLSKFD----CGRI-IGSIVDLLQPSHQMLNETKLSLLRLCAR 1990
               |..|:..|           ||.|..    |||: :|.:|                 |.:...
Human   144 DVAGDTPLAVR-----------GLLKDGPAQRCGRLEVGDLV-----------------LHINGE 180

  Fly  1991 LTRNYDNAQVF--IRRGGVRMLLHLQQACSFMGFPTYANIILRHVLEAPPVLQEAMERVLGMRAA 2053
            .|:...:||..  ||.||.:  |||               ::|..||..|    ...|.:|....
Human   181 STQGLTHAQAVERIRAGGPQ--LHL---------------VIRRPLETHP----GKPRGVGEPRK 224

  Fly  2054 GIVPVGHRDLIYVLTQVSSAVSRNPQIFVAAAKEMLKGEYLINTNSTTLAD--DARVMVKSKFGQ 2116
            |:||              |...|:|.   ....|:...    .::||:|..  .:|..:|...|.
Human   225 GVVP--------------SWPDRSPD---PGGPEVTGS----RSSSTSLVQHPPSRTTLKKTRGS 268

  Fly  2117 ---QPTAAAGGATPHNQTPTPPPAAKDELKDDPQVQSSVAVLKELLHGLVQPCWHYGGTGSLDRG 2178
               .|.|||.|.|      ..||..:.|   ||..|         :.|...| |.......|.|.
Human   269 PEPSPEAAADGPT------VSPPERRAE---DPNDQ---------IPGSPGP-WLVPSEERLSRA 314

  Fly  2179 ---QGAAELLQ 2186
               :|||:|.|
Human   315 LGVRGAAQLAQ 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033
		HECTc	4820..5148	CDD:214523
MAGIX	NP_079135.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		2/4 (50%)
		PDZ_signaling	124..206	CDD:238492	23/126 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..306		33/140 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900