DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and HECTD3

DIOPT Version :10

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_078878.3 Gene:HECTD3 / 79654 HGNCID:26117 Length:861 Species:Homo sapiens


Alignment Length:466 Identity:110/466 - (23%)
Similarity:196/466 - (42%) Gaps:97/466 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  4723 AQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERLDE 4787
            ::::|.:| ||..:.:...::.|.||.|.:  |...|             :.|.|....|..   
Human   437 SEIKQVKQ-FLLLSRQRPGLVAQCLRDSES--SKPSF-------------MPRLYINRRLAM--- 482

  Fly  4788 GIRREEHTVSVRRVTVFEDS-FRVLYR-LGPEE---------WKNRFYIVFEDE---EG-QDAGG 4837
                 ||.....|....::: |..:|. |.|.:         |..|:...:|.:   || .|.||
Human   483 -----EHRACPSRDPACKNAVFTQVYEGLKPSDKYEKPLDYRWPMRYDQWWECKFIAEGIIDQGG 542

  Fly  4838 LLREWYVIISREIFNPMYALFCVSPGD---------------------RVTYMINPSSHANPNHL 4881
            ..|:....:|.|:        |.|..|                     |..|:.|||.    ...
Human   543 GFRDSLADMSEEL--------CPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNPSC----RDF 595

  Fly  4882 SYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHT-DMESQDYEFYKGLDYLMKNDIST- 4944
            :.::::|:::..|:...:.|........:|.:.|::|..: |..:.|....|.|:.:...|..| 
Human   596 AKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVMEGMDKETF 660

  Fly  4945 ---LGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEG 5006
               .|.||||:|.:.:   .|:.:|.|.|....|...::..::|||.:.::..| ::|:.|...|
Human   661 EFKFGKELTFTTVLSD---QQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEES-KEQVAAMQAG 721

  Fly  5007 FYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRA 5071
            ...::|:.::.:...||||..:.|.|::.::.|:..|.:..:....:::|:||.||.:|...||:
Human   722 LLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDSRVQYFWEALNNFTNEDRS 786

  Fly  5072 KFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDD---RSTDRLPCAHTCFNQLDLPMYKSYDKL 5133
            :||:||||.|::|             .:..|:.|.   .:||.||.:.||.:.|.||.|.|....
Human   787 RFLRFVTGRSRLP-------------ARIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVC 838

  Fly  5134 RSCLLKAIHEC 5144
            ...|..|.:.|
Human   839 EEKLRYAAYNC 849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:428721
DUF913 621..989 CDD:461803
UBA_like_SF 1467..1506 CDD:473871
WWE 1756..1828 CDD:128922
DUF5585 3288..3672 CDD:465521
UBM 3670..3700 CDD:464159
UBM 3719..3746 CDD:464159
HECTc 4796..5149 CDD:238033 95/393 (24%)
HECTD3NP_078878.3 APC10-HECTD3 238..371 CDD:176487
HECT 579..845 CDD:459880 74/286 (26%)
Blue background indicates that the domain is not in the aligned region.

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