Protein Alignment HUWE1 and ube3a

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_001007319.1
• Gene: ube3a / 792398
• ZFINID: ZDB-GENE-041114-190
• Length: 857
• Species: Danio rerio
• Alignment Length: 1110
• Identity: 238/1110 - (21%)
• Similarity: 403/1110 - (36%)
• Gaps: 360/1110 - (32%)

  Fly  4085 DDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAGSQNKHSVPYQTNAKNFWDVVLNIDQQTQV 4149
            |.||:.|      .|.|.....:||.|......:.|..|...:|  ...::|.|  ||.
Zfish    61 DPHPSKK------GASSAFPENSAKGAHNFSACSNGKMNHKDLP--PTREDFRD--LNF------ 109

  Fly  4150 RLANVAQFPLTSQPAWEWQ---PNTADFLSFSESPFGQLLEMLPYKVICRSPHLTDMLVKLLASL 4211
                     ||....:|..   ..|.|:     ||.        .:||.|.....:.||:.....
Zfish   110 ---------LTEDKVYEILSICSETEDY-----SPL--------IRVIGRVFSSAESLVQSFRKA 152

  Fly  4212 STELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENTATATEIGDGLAANIEEQ 4276
            .....:|.:.|...|:                           ..:.....|..|...|..:|.:
Zfish   153 KQHTKEELKSLQAKDE---------------------------DKDEDEKETASGSSTAMEVEPE 190

  Fly  4277 ASPASGNPAS-GDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEG 4340
            ||.:||:.:| |::|.    .:|..:.|::.:...   |::|.:..|
Zfish   191 ASASSGDGSSHGENNV----QKLGPVEVSVDIDAV---RRVYDRLLS------------------ 230

  Fly  4341 LDNVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNIHQGGAGTTSQAA 4405
                          ::...|.|:.    |::.|:..|.       .::..:|::
Zfish   231 --------------NEKIEAAFLN----ALVYLSPNVE-------CDLTYHNVY----------- 259

  Fly  4406 STSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKL-- 4468
                  ||..:|:...  ..::.|..:|        :.|::.|:.|:..|...:|.||::.||
Zfish   260 ------AADPNYLNVF--IIVMENSNLH--------SPEYLEIALPQFCKAMSKLPLPALAKLAR 308

  Fly  4469 MSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDD-------IIDIEGDGGASG 4526
            :.:........|.::.|.|:.......|..|:...|      |:||       .:.|.......|
Zfish   309 LWSQYGVDQIRRLVETFQQLITYTVISNEFSSDNLV------NEDDGVVAATKCLKIVYYANVLG 367

  Fly  4527 GSSSDMAPGSASTISPPPPMETNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQIL 4591
            |   |:                     |.|.:||||||             ...:|::.||.::|
Zfish   368 G---DL---------------------DTDHNEEDDDE-------------PIPESSELTLQELL 395

  Fly  4592 CLDVLWNTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAA 4656
            .               ||.::                          |.|....|.....|:|
Zfish   396 G---------------EERRN--------------------------KKGPRVDPLETEMGIR-- 417

  Fly  4657 AGAGAIGGLGAAAPSAQEYSPFMDDVSSANTPSS---------ASFDDEPRMQDASTNTPLVTNP 4712
                       |:...:...||.:.:   |.|.:         ..|..|...:.:....|.:.|.
Zfish   418 -----------ASDCRKPLIPFEEFI---NEPLNEVLEMDKDYTFFKVETESKFSFMTCPFILNA 468

  Fly  4713 STSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKY 4777
            .|......::.::|       .::|:..|.|                                 |
Zfish   469 VTKNLGLYYDNRIR-------MYSERRITAL---------------------------------Y 493

  Fly  4778 FQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRL------GPEEWKNRFYIVFEDEEGQDAG 4836
            ...:.::|:..:|     :.|||..:.:|:   |.||      .|.:.|.:.|:.||.|:|.|.|
Zfish   494 SLVQGQQLNPYLR-----LKVRRDHIIDDA---LVRLEMIAMENPADLKKQLYVEFEGEQGVDEG 550

  Fly  4837 GLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLL 4901
            |:.:|::.::..|||||...:|......:: :..||||..|...   |..:|.|:..|:::|.:|
Zfish   551 GVSKEFFQLVVEEIFNPDIGMFTYDESTKL-FWFNPSSFENEGQ---FTLIGIVLGLAIYNNCIL 611

  Fly  4902 ECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYE--------LTFS-TEVQE 4957
            :.:|....|:.::||:....|:.......::.|..||:       ||        :||. ::...
Zfish   612 DVHFPMVIYRKLMGKKGTFRDLADSHPVLFQSLKDLME-------YEGNVEEDMMITFQISQTDL 669

  Fly  4958 FGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLIS----- 5017
            ||...:.|||.:|....||.||:.::|.|..:..::.|:.:|..||..||      |:::
Zfish   670 FGNPLMYDLKESGDKIPVTNENRKDFVALYAEYMLNKSVEKQFKAFRRGF------HMVTNESPL 728

  Fly  5018 --IFNEQELELLISGLPDIDIEDLKANTEYH-KYTSKSAQIQWFWRALRSFDQADRAKFLQFVTG 5079
              :|..:|:||||.|..::|.:.|:.:|||. .|...|..|:.||..:.||:|..:..||||.||
Zfish   729 KYLFRPEEIELLICGSRNLDFQALEESTEYDGGYNKDSRIIRDFWETVHSFEQEKKRLFLQFTTG 793

  Fly  5080 TSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHEC 5144
            |.:.|:.|.|.|       |..|.::...:||||.:|||||.|.||.|.:.:||:..||||| ..
Zfish   794 TDRAPVGGLGKL-------KMIIAKNGPDSDRLPTSHTCFNVLLLPEYSTVEKLKERLLKAI-TY 850

  Fly  5145 SEGFG 5149
            ::|||
Zfish   851 AKGFG 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	120/375 (32%)
ube3a	NP_001007319.1	AZUL	6..60	CDD:465173
		HECTc	505..855	CDD:238033	121/382 (32%)