DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HUWE1 and itch

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_001072737.1 Gene:itch / 780194 XenbaseID:XB-GENE-976485 Length:853 Species:Xenopus tropicalis


Alignment Length:814 Identity:235/814 - (28%)
Similarity:358/814 - (43%) Gaps:154/814 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly  4429 NLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYE 4493
            :|.:||.::.:....|.||::          :||.|.::.:.:.|.             ..|..:
 Frog    99 SLNLHETLLSNNMKLEEVIVT----------MQLLSDRETVGDLSV-------------CLDGMQ 140

  Fly  4494 AQNGLSTGGGVACGAGDNDDDIIDIEGDGGA---------------SGGSSSDMAPGSASTISPP 4543
            ....|...|..|..:|..|:...::|....:               :|.||..:|.|......||
 Frog   141 VDPELLANGDPAVSSGSTDNSSTEVESQAASAESSNGTNSTDSRTTNGMSSPSLANGGFKASRPP 205

  Fly  4544 ----PPMETNQIAQD-----GDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDV---- 4595
                ||..|.:.|..     .:.....:.|....|...:...|.|..||.|...||..::|    
 Frog   206 RPSRPPPPTPRRASGVVTAISEAPPPPEAELLPTPATASLPEAQAPSSTPPVSRQIAPINVDGQR 270

  Fly  4596 ---------------------------------LWNTLSECLVALEESKDEFAVLVL-------- 4619
                                             .|:.........|...|....:..        
 Frog   271 MGLVNQGPLPPGWEQRVDQQGRVYYVDHVAKRTTWDRPEPLPPGWERRVDNMGRIYYVDHITRTT 335

  Fly  4620 ---QPTVEA------FFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEY 4675
               :||:|:      :.|.....:||.::..:.|:                .|.........:||
 Frog   336 TWQRPTLESVRNYEQWQLQRNQLQGAMQQFNQRFI----------------YGTQETGTTQNKEY 384

  Fly  4676 SPF----------MDD---VSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQ 4727
            .|.          ||.   |...|..:..:..::||.|......||         ....|.:...
 Frog   385 DPLGPLPVGWEKRMDGNGRVYFVNHTTRTTQWEDPRNQGQLNEKPL---------PEGWEMRFTV 440

  Fly  4728 DRQKFLQFAEKHRTVLNQI-LRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERLDEGIRR 4791
            |...:  |.:.:|.....| .|...:.|.:||....|     .||..|.:||:...::|    ..
 Frog   441 DGIPY--FVDHNRKTTTYIDPRTGKSALDNGPHIAYV-----RDFKAKVQYFRFWCQQL----YM 494

  Fly  4792 EEHT-VSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMY 4855
            .:|. ::|.|.|:|||||:.:.....::.:.|.:|:...|||.|.||:.|||:.::|.|:.||||
 Frog   495 PQHVKITVNRKTLFEDSFQQIMSFNAQDLRRRLWIIIPGEEGLDYGGVAREWFFLLSHEVMNPMY 559

  Fly  4856 ALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKH 4920
            .||..:..|.....|||:|:.||:||.||:|:||.||.|:...|.::..|:..|||.||.|.|..
 Frog   560 CLFEYAGKDNYCLQINPASYINPDHLRYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGL 624

  Fly  4921 TDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQ 4985
            .|:||.|.|||..|.::..|:|...|.|:.||.:.:..|..:..||||:|.:..||||||.||::
 Frog   625 KDLESVDPEFYNSLIWIKDNNIEECGLEMFFSVDKEILGDVKSHDLKPDGSNIQVTEENKEEYIR 689

  Fly  4986 LVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTS 5050
            ||.:.::|..:.:|..||.|||.:|:|:..:..|:.:|||:|:.|:.:||:.|.:.||.|..||.
 Frog   690 LVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRNTIYRHYTR 754

  Fly  5051 KSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCA 5115
            .|.||.|||:.::..|...|.:.|||||||.::|:.||..|.|.||.|||.|.:..:. :.||.:
 Frog   755 TSKQIIWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKE-NWLPRS 818

  Fly  5116 HTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
            |||||:||||.||||::|:..||.||.| :||||
 Frog   819 HTCFNRLDLPPYKSYEQLKEKLLFAIEE-TEGFG 851

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033 155/352 (44%)
HECTc 4820..5148 CDD:214523 146/327 (45%)
itchNP_001072737.1 C2_E3_ubiquitin_ligase 17..137 CDD:175988 10/60 (17%)
WW 279..308 CDD:306827 1/28 (4%)
HUL4 <310..853 CDD:227354 196/580 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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