DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HUWE1 and Smurf1

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	XP_006504947.1	Gene:	Smurf1 / 75788	MGIID:	1923038	Length:	757	Species:	Mus musculus

Alignment Length:	465	Identity:	176/465 - (37%)
Similarity:	261/465 - (56%)	Gaps:	49/465 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  4701 DASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHL-SDGPFAVLVD 4764
            |.:..|...|:|.....|: |:.||::..|                    |..| |:|
Mouse   326 DHNNRTTQFTDPRLHHIMN-HQCQLKEPSQ--------------------PLQLPSEG------- 362

  Fly  4765 HTRILDFDVKRKYFQTELERLDEGIRRE---------EHTVSVRRVTVFEDSFRVLYRLGPEEWK 4820
              .:.|.::..:.::.:|.:..:.:|.|         ...:.|.|..:||:|:|.:.::.|::.|
Mouse   363 --SVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLK 425

  Fly  4821 NRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFK 4885
            .|..:.|..|||.|.||:.|||..::..|:.||.|.||..|..:..|..|||.|..||:|||||.
Mouse   426 KRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFH 490

  Fly  4886 FVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELT 4950
            ||||::..||.....:...||..|||.:|||.::.:|:||.|.|.:|.|.::::|||:.: .:.|
Mouse   491 FVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHT 554

  Fly  4951 FSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHL 5015
            |..|...||.....:||||||:..||||||.|||:|....:....|..|..|..:||.::||:||
Mouse   555 FCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHL 619

  Fly  5016 ISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGT 5080
            :..|:::||||:|.||..||:.|.|:||......:.|..::|||:|:.:||:..||:.||||||:
Mouse   620 LKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGS 684

  Fly  5081 SKVPLQGFGSLEGMNGI---QKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIH 5142
            ::||||||.:|:|..|.   :.|.||..|.:||.||.||||||::|:|.|:||:||...||.|:.
Mouse   685 TRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 749

  Fly  5143 E-CSEGFGFA 5151
            | |    |||
Mouse   750 ETC----GFA 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	156/356 (44%)
		HECTc	4820..5148	CDD:214523	149/331 (45%)
Smurf1	XP_006504947.1	C2_Smurf-like	14..138	CDD:176028
		WW	236..267	CDD:197736
		WW	307..339	CDD:197736	4/12 (33%)
		HECTc	399..754	CDD:238033	156/359 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810