DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and hace1

DIOPT Version :10

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_012818577.2 Gene:hace1 / 734146 XenbaseID:XB-GENE-5757512 Length:1012 Species:Xenopus tropicalis


Alignment Length:883 Identity:259/883 - (29%)
Similarity:392/883 - (44%) Gaps:167/883 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly  4366 LTA----AILGLAEEVRQAIQMLLN--------EIRMYNIHQGGAGTTSQAASTSGAAAATASYV 4418
            |||    |:.|..|.:...:|.:.|        :..::...|.|..||......|||....    
 Frog   200 LTAIHWLAVNGRTELLHDLVQHVTNVDVEDAMGQTALHVACQNGHKTTVLCLLDSGADINR---- 260

  Fly  4419 PTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPK------NAKP-----------TCELQL---- 4462
            |.||||:.|.....|    ..|.||:.:::...|      ...|           ||::.:    
 Frog   261 PNVSGATPLYFACSH----GQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETCDILIQHHP 321

  Fly  4463 ---PSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGD--- 4521
               .::.::..|...:...||  ::...:....|.|. |....|:|..|..|...::.|...   
 Frog   322 RLFQTLIQMTQNEDLRENTLR--QVLEHLSQQSEVQY-LKILTGLAEVATTNGHKLLSISSSYEA 383

  Fly  4522 ------------------GGASGGSSSDMAPGSASTISPPPPMETNQIAQDGDDDEEDDDEARSF 4568
                              |.:|..:.:||......|    |..:..::....|...:.:.:..:.
 Frog   384 QMKSLLRIVRIFCHVFRIGPSSPNNGNDMGYNGNKT----PRNQVFKVRNVYDVFRKINIKEMNL 444

  Fly  4569 PGVGNHA-VASASKSTKPTLSQILCLDVLWNTLSE--CLVALEESKDE-----FAVLVLQPTVEA 4625
            |   ||. :..|:....|       |::||::|.|  .|:|.|.:|::     .|.::|:.....
 Frog   445 P---NHTLIYQATSEQDP-------LELLWHSLDEWLVLIATELTKNKRDSSNIACILLKQNQLD 499

  Fly  4626 FFLIHASHRGASKKSGR----SFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSPFMD--DVSS 4684
            ...|..:|:.|..:||.    |....|..|...:|||               :..|..|  ||.|
 Frog   500 QQDISLAHQSAIGESGSYDHLSSSTRAEDFESCSAAG---------------KQEPVADGQDVIS 549

  Fly  4685 ANTPSSASFDDEPRMQDASTNTPL-VTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILR 4748
            . |.:..|...:......|...|. :|:|                  :|::|..||..||...:.
 Frog   550 M-TANRLSAVIQAFYMCCSCQMPQGMTSP------------------RFIEFVCKHDDVLKCFVT 595

  Fly  4749 QSPTHLSDGPFAVLVDH-----------TRILDFDVKRKYFQTELERLDEGIR------------ 4790
            ::|        .::.||           :|.:.. :|.:.|:...|...|.:.            
 Frog   596 RNP--------KIIFDHFHFLLECPELMSRFMHI-IKAQPFKERCEWFYEHLLAGQPDSDMVHRP 651

  Fly  4791 -REEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPM 4854
             .|...:.|.|.::|..|..|:::...|:.|....:.|..|||. ..|::|||:.|:|.||.||.
 Frog   652 VNENDILLVHRDSIFRSSCEVVFKSNCEKLKQGIAVRFHGEEGM-GQGVVREWFDILSSEIINPD 715

  Fly  4855 YALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVK 4919
            ||||..| .|..|:..|.:|..||:||:||:|.|.::..|::..:|:..||||||||||||..|.
 Frog   716 YALFTQS-ADGTTFQPNSNSSVNPDHLNYFRFAGEILGLALYHRQLVNIYFTRSFYKHILGIPVN 779

  Fly  4920 HTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYV 4984
            :.|:.|.|.|:.|.|.:::.||||.||.|||||.|...||..:...|||.|....||:|||.|||
 Frog   780 YQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGASILVTQENKAEYV 844

  Fly  4985 QLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHK-Y 5048
            |||.:|:|:.:|:.|::.||:||:..||..||.:|:|.|||||:||:|:||:.|...||||.. |
 Frog   845 QLVTELRMTRAIQPQINGFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWMKNTEYTSGY 909

  Fly  5049 TSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLP 5113
            ......|||||..::...|.:|...||||||:|:||..||..:.|.:|:|.|.|.....:.:.||
 Frog   910 ERDDQVIQWFWEVVQELTQEERVLLLQFVTGSSRVPHGGFAYIMGGSGLQNFTIAAVAYTPNLLP 974

  Fly  5114 CAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFGFA 5151
            .:.||.|.|.||.|.|.:.|:..||.|:|..|.|:..|
 Frog   975 TSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGYTMA 1012

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:428721
DUF913 621..989 CDD:461803
UBA_like_SF 1467..1506 CDD:473871
WWE 1756..1828 CDD:128922
DUF5585 3288..3672 CDD:465521
UBM 3670..3700 CDD:464159
UBM 3719..3746 CDD:464159
HECTc 4796..5149 CDD:238033 158/353 (45%)
hace1XP_012818577.2 ANKYR 66..317 CDD:440430 29/124 (23%)
ANK repeat 134..163 CDD:293786
ANK repeat 165..196 CDD:293786
ANK repeat 198..229 CDD:293786 8/28 (29%)
ANK repeat 231..262 CDD:293786 7/34 (21%)
ANK repeat 264..289 CDD:293786 8/28 (29%)
HECTc 657..1006 CDD:238033 156/350 (45%)
Blue background indicates that the domain is not in the aligned region.

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