DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and hace1

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	XP_012818577.2	Gene:	hace1 / 734146	XenbaseID:	XB-GENE-5757512	Length:	1012	Species:	Xenopus tropicalis

Alignment Length:	883	Identity:	259/883 - (29%)
Similarity:	392/883 - (44%)	Gaps:	167/883 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  4366 LTA----AILGLAEEVRQAIQMLLN--------EIRMYNIHQGGAGTTSQAASTSGAAAATASYV 4418
            |||    |:.|..|.:...:|.:.|        :..::...|.|..||......|||....
Frog   200 LTAIHWLAVNGRTELLHDLVQHVTNVDVEDAMGQTALHVACQNGHKTTVLCLLDSGADINR---- 260

  Fly  4419 PTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPK------NAKP-----------TCELQL---- 4462
            |.||||:.|.....|    ..|.||:.:::...|      ...|           ||::.:
Frog   261 PNVSGATPLYFACSH----GQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETCDILIQHHP 321

  Fly  4463 ---PSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGD--- 4521
               .::.::..|...:...||  ::...:....|.|. |....|:|..|..|...::.|...
Frog   322 RLFQTLIQMTQNEDLRENTLR--QVLEHLSQQSEVQY-LKILTGLAEVATTNGHKLLSISSSYEA 383

  Fly  4522 ------------------GGASGGSSSDMAPGSASTISPPPPMETNQIAQDGDDDEEDDDEARSF 4568
                              |.:|..:.:||......|    |..:..::....|...:.:.:..:.
Frog   384 QMKSLLRIVRIFCHVFRIGPSSPNNGNDMGYNGNKT----PRNQVFKVRNVYDVFRKINIKEMNL 444

  Fly  4569 PGVGNHA-VASASKSTKPTLSQILCLDVLWNTLSE--CLVALEESKDE-----FAVLVLQPTVEA 4625
            |   ||. :..|:....|       |::||::|.|  .|:|.|.:|::     .|.::|:.....
Frog   445 P---NHTLIYQATSEQDP-------LELLWHSLDEWLVLIATELTKNKRDSSNIACILLKQNQLD 499

  Fly  4626 FFLIHASHRGASKKSGR----SFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSPFMD--DVSS 4684
            ...|..:|:.|..:||.    |....|..|...:|||               :..|..|  ||.|
Frog   500 QQDISLAHQSAIGESGSYDHLSSSTRAEDFESCSAAG---------------KQEPVADGQDVIS 549

  Fly  4685 ANTPSSASFDDEPRMQDASTNTPL-VTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILR 4748
            . |.:..|...:......|...|. :|:|                  :|::|..||..||...:.
Frog   550 M-TANRLSAVIQAFYMCCSCQMPQGMTSP------------------RFIEFVCKHDDVLKCFVT 595

  Fly  4749 QSPTHLSDGPFAVLVDH-----------TRILDFDVKRKYFQTELERLDEGIR------------ 4790
            ::|        .::.||           :|.:.. :|.:.|:...|...|.:.
Frog   596 RNP--------KIIFDHFHFLLECPELMSRFMHI-IKAQPFKERCEWFYEHLLAGQPDSDMVHRP 651

  Fly  4791 -REEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPM 4854
             .|...:.|.|.::|..|..|:::...|:.|....:.|..|||. ..|::|||:.|:|.||.||.
Frog   652 VNENDILLVHRDSIFRSSCEVVFKSNCEKLKQGIAVRFHGEEGM-GQGVVREWFDILSSEIINPD 715

  Fly  4855 YALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVK 4919
            ||||..| .|..|:..|.:|..||:||:||:|.|.::..|::..:|:..||||||||||||..|.
Frog   716 YALFTQS-ADGTTFQPNSNSSVNPDHLNYFRFAGEILGLALYHRQLVNIYFTRSFYKHILGIPVN 779

  Fly  4920 HTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYV 4984
            :.|:.|.|.|:.|.|.:::.||||.||.|||||.|...||..:...|||.|....||:|||.|||
Frog   780 YQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGASILVTQENKAEYV 844

  Fly  4985 QLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHK-Y 5048
            |||.:|:|:.:|:.|::.||:||:..||..||.:|:|.|||||:||:|:||:.|...||||.. |
Frog   845 QLVTELRMTRAIQPQINGFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWMKNTEYTSGY 909

  Fly  5049 TSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLP 5113
            ......|||||..::...|.:|...||||||:|:||..||..:.|.:|:|.|.|.....:.:.||
Frog   910 ERDDQVIQWFWEVVQELTQEERVLLLQFVTGSSRVPHGGFAYIMGGSGLQNFTIAAVAYTPNLLP 974

  Fly  5114 CAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFGFA 5151
            .:.||.|.|.||.|.|.:.|:..||.|:|..|.|:..|
Frog   975 TSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGYTMA 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	158/353 (45%)
		HECTc	4820..5148	CDD:214523	151/328 (46%)
hace1	XP_012818577.2	PLN03192	<19..289	CDD:215625	25/96 (26%)
		ANK repeat	134..163	CDD:293786
		ANKYR	<160..288	CDD:223738	25/95 (26%)
		ANK repeat	165..196	CDD:293786
		ANK repeat	198..229	CDD:293786	8/28 (29%)
		ANK repeat	231..262	CDD:293786	7/34 (21%)
		ANK repeat	264..289	CDD:293786	8/28 (29%)
		HECTc	657..1006	CDD:238033	156/350 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140374at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020