DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and Arel1

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_001351118.1	Gene:	Arel1 / 68497	MGIID:	1915747	Length:	823	Species:	Mus musculus

Alignment Length:	400	Identity:	137/400 - (34%)
Similarity:	214/400 - (53%)	Gaps:	38/400 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  4771 FDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDA 4835
            |..|..:||.||.::.......:.|:.|.|..:.|.|.:........:|...|.:||:|||..|.
Mouse   439 FQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDW 503

  Fly  4836 GGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPN-----HLSYFKFVGRVIAKAV 4895
            ||..|||:.:|.:.:|:....||.     |.|.......|.|||     .|..::|.||::.|.:
Mouse   504 GGPRREWFELICKALFDTTSQLFA-----RFTDSNQALVHPNPNRPAHLRLKMYEFAGRLVGKCL 563

  Fly  4896 HDNKLLECY-------FTRSFYKHILGKQVKHTDMESQDYEFYKG-LDYLMKNDISTLGYELTFS 4952
            :::.|...|       |||||...|:|.::.:...|:.|.||||. :.:::.||:|.:  ||.|:
Mouse   564 YESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEM--ELVFA 626

  Fly  4953 TE-VQEFG-VTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHL 5015
            .| ..:.| :.:|.:|...|..|.||..||..|:.|:.|.:::..::::::.||:|..:::|::|
Mouse   627 EEKYNKSGQLDKIVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENL 691

  Fly  5016 ISIFNEQELELLISGLPDIDIEDLKANT-----EYHKYTSKSAQIQWFWRALRSFDQADRAKFLQ 5075
            ::||:|.|||||:.|..||::.|.||:.     .:|   .:...::|||..:.|..|.:.|:.||
Mouse   692 LAIFDENELELLMCGTGDINVSDFKAHAVVVGGSWH---FREKVMRWFWAVVSSLTQEELARLLQ 753

  Fly  5076 FVTGTSKVPLQGFGSLEGMNGIQKFQ-IHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLK 5139
            |.||:|::|..||.:|     ...|| |.....||  ||.||||||||.||.|.||:::...|..
Mouse   754 FTTGSSQLPPGGFAAL-----CPSFQIIAAPTHST--LPTAHTCFNQLCLPTYDSYEEVHRMLQL 811

  Fly  5140 AIHECSEGFG 5149
            ||.|..||||
Mouse   812 AISEGCEGFG 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	128/373 (34%)
		HECTc	4820..5148	CDD:214523	122/348 (35%)
Arel1	NP_001351118.1	Filamin	56..154	CDD:395505
		Filamin	64..158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..345
		HECTc	464..821	CDD:238033	128/373 (34%)
		Interaction with SOCS2. /evidence=ECO:0000250\|UniProtKB:O15033	483..789		106/322 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140374at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820