DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HUWE1 and Herc6

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_080268.1 Gene:Herc6 / 67138 MGIID:1914388 Length:1003 Species:Mus musculus


Alignment Length:414 Identity:107/414 - (25%)
Similarity:182/414 - (43%) Gaps:40/414 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly  4752 THLSDGPFAVLVDHTRILDFDVKRKYFQ--------TELERLDEGIRREEHTV-SVRRVTVFEDS 4807
            |..||  ..|..|...:.|...|.|..:        :|:....|.:....:.: .|||..:.||:
Mouse   609 TESSD--MVVFSDFLFVFDLPSKIKLMKCDSFVKLMSEVMAFPEKMSSPPYLILKVRRSHLVEDT 671

  Fly  4808 FRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSP--GDRVTYMI 4870
            .|.|.::...:.:.:..:.|.:|...:|||:..|::..|..|:.:|.|.:| :.|  |..:.:.:
Mouse   672 LRQLRQVEDFDLRKQLSVGFINEIRPEAGGVSSEFFHCIFEEMTDPKYEMF-IYPEKGSSMWFPV 735

  Fly  4871 NPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLD 4935
            ||....:    |||.| |.:...::|:.|::...|..:.||.:|.::....|::.......:.|.
Mouse   736 NPKFEKS----SYFLF-GILCGLSLHNLKVINLPFPLALYKKLLNQKPSLEDLKELSLPLGRNLQ 795

  Fly  4936 YLMK---NDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIR 4997
            .::.   .||..|  .:.||....:..|    ||.|:|....|.|.||.:||........:.||:
Mouse   796 EVLNCEAGDIEEL--HMYFSIYWDQKDV----DLIPDGISVPVNETNKRDYVSKYVDYIFNISIK 854

  Fly  4998 QQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHK-YTSKSAQIQWFWRA 5061
            ...:.|..|||.:....:|..|..:||...|.|....|.:..:.|::|.. |......|..||:|
Mouse   855 TIYEEFHRGFYKVCNWDIIRQFQPEELMTAIIGNATCDWKQFENNSKYKDGYDKSHPTILLFWKA 919

  Fly  5062 LRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHR--DDRSTDRLPCAHTCFNQLDL 5124
            .......::.|||.|:||..::.::|..: ||:       :.|  :..|.:..|.:.||...|||
Mouse   920 FHDLTLDEKKKFLLFLTGCDRLHVKGLQN-EGI-------VFRCSETFSEEDNPRSLTCHRMLDL 976

  Fly  5125 PMYKSYDKLRSCLLKAIHECSEGF 5148
            |.|.|..:::..|..||:. |.||
Mouse   977 PKYSSMRRMKEALQVAINN-STGF 999

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033 97/362 (27%)
HECTc 4820..5148 CDD:214523 88/335 (26%)
Herc6NP_080268.1 RCC1 1 40..91
RCC1 40..89 CDD:278826
RCC1 2 92..144
RCC1 92..142 CDD:278826
RCC1 145..195 CDD:278826
RCC1 3 146..197
RCC1_2 183..211 CDD:290274
RCC1 4 199..252
RCC1_2 237..266 CDD:290274
RCC1 5 253..303
RCC1 253..300 CDD:278826
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..281
chaperonin_like <570..>652 CDD:295468 10/44 (23%)
HECTc 658..999 CDD:238033 95/361 (26%)
HECTc 682..999 CDD:214523 88/337 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.