DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HUWE1 and Smurf2

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_079757.2	Gene:	Smurf2 / 66313	MGIID:	1913563	Length:	748	Species:	Mus musculus

Alignment Length:	463	Identity:	180/463 - (38%)
Similarity:	257/463 - (55%)	Gaps:	50/463 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  4696 EPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFA 4760
            :||:   |.|..||.|         .:.||:..:|:             |::...|
Mouse   327 DPRL---SANLHLVLN---------RQNQLKDQQQQ-------------QVVPLCP--------- 357

  Fly  4761 VLVDHTRILDFDVKRKYFQTELERLDEGIRREE----H-TVSVRRVTVFEDSFRVLYRLGPEE-W 4819
               |.|..|.....::....:|:.|.:.:.:::    | .:.|.|..:||:|:|.:.::.|:: |
Mouse   358 ---DDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLW 419

  Fly  4820 KNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYF 4884
            | |..|.|..|||.|.||:.|||..::|.|:.||.|.||..|..|..|..|||.|..||.|||||
Mouse   420 K-RLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYF 483

  Fly  4885 KFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYEL 4949
            .||||::..||.....::..||..|||.:|||.:...|||..|.:.:..|.::::|||:.: .:.
Mouse   484 HFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGV-LDH 547

  Fly  4950 TFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKH 5014
            ||..|...:|.....:|||||:...||||||.|||:|....:....|..|..|..:||.::||:|
Mouse   548 TFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQH 612

  Fly  5015 LISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTG 5079
            |:..|:|:||||:|.||..||:.|.|.||.....|..|..::|||:|:..||:..||:.||||||
Mouse   613 LLKTFDEKELELIICGLGKIDVSDWKVNTRLKHCTPDSNVVKWFWKAVEFFDEERRARLLQFVTG 677

  Fly  5080 TSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHE- 5143
            :|:||||||.:|:|..|.:.|.||:.|..|:.||.||||||::|:|.|:||:||...||.||.|
Mouse   678 SSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEET 742

  Fly  5144 CSEGFGFA 5151
            |    |||
Mouse   743 C----GFA 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	159/354 (45%)
		HECTc	4820..5148	CDD:214523	151/328 (46%)
Smurf2	NP_079757.2	C2_Smurf-like	13..137	CDD:176028
		WW	159..188	CDD:278809
		WW	252..283	CDD:197736
		WW	298..330	CDD:197736	1/2 (50%)
		HECTc	393..745	CDD:238033	159/357 (45%)
		HECTc	420..745	CDD:214523	151/330 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810