DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and SMURF2

DIOPT Version :10

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_047292502.1 Gene:SMURF2 / 64750 HGNCID:16809 Length:750 Species:Homo sapiens


Alignment Length:463 Identity:179/463 - (38%)
Similarity:256/463 - (55%) Gaps:50/463 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly  4696 EPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFA 4760
            :||:   |.|..||.|         .:.||:..:|:             |::...|         
Human   329 DPRL---SANLHLVLN---------RQNQLKDQQQQ-------------QVVSLCP--------- 359

  Fly  4761 VLVDHTRILDFDVKRKYFQTELERLDEGIRREE----H-TVSVRRVTVFEDSFRVLYRLGPEE-W 4819
               |.|..|.....::....:|:.|.:.:.:::    | .:.|.|..:||:|:|.:.::.|:: |
Human   360 ---DDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLW 421

  Fly  4820 KNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYF 4884
            | |..|.|..|||.|.||:.|||..::|.|:.||.|.||..|..|..|..|||.|..||.|||||
Human   422 K-RLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYF 485

  Fly  4885 KFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYEL 4949
            .||||::..||.....::..||..|||.:|||.:...|||..|.:.:..|.::::|||:.: .:.
Human   486 HFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGV-LDH 549

  Fly  4950 TFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKH 5014
            ||..|...:|.....:|||||:...|.||||.|||:|....:....|..|..|..:||.::||:|
Human   550 TFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQH 614

  Fly  5015 LISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTG 5079
            |:..|:|:||||:|.||..||:.|.|.||.....|..|..::|||:|:..||:..||:.||||||
Human   615 LLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTG 679

  Fly  5080 TSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHE- 5143
            :|:||||||.:|:|..|.:.|.||:.|..|:.||.||||||::|:|.|:||:||...||.||.| 
Human   680 SSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEET 744

  Fly  5144 CSEGFGFA 5151
            |    |||
Human   745 C----GFA 748

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:428721
DUF913 621..989 CDD:461803
UBA_like_SF 1467..1506 CDD:473871
WWE 1756..1828 CDD:128922
DUF5585 3288..3672 CDD:465521
UBM 3670..3700 CDD:464159
UBM 3719..3746 CDD:464159
HECTc 4796..5149 CDD:238033 158/354 (45%)
SMURF2XP_047292502.1 C2_Smurf-like 19..139 CDD:176028
HUL4 <161..747 CDD:227354 176/460 (38%)
Blue background indicates that the domain is not in the aligned region.

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