DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HUWE1 and HACE1

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_065822.2 Gene:HACE1 / 57531 HGNCID:21033 Length:909 Species:Homo sapiens


Alignment Length:978 Identity:265/978 - (27%)
Similarity:414/978 - (42%) Gaps:205/978 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  4293 AKRTQLP-----TLSVALPVTPSKPRRKI--------YSKN--FSQLQLVIEVLTHQCGTTEGLD 4342
            |:..:||     .:...:|:..:...|.:        :..|  |.:::..:..:...||:.|.|.
Human    18 ARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLV 82

  Fly  4343 NVAKLIVN-----LTQCSQASSAI----------FIQY-----------LTA----AILGLAEEV 4377
            .:.|...|     ::.|:....|.          .::|           |||    |:.|..|.:
Human    83 LLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELL 147

  Fly  4378 RQAIQML--------LNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHE 4434
            ...:|.:        :.:..::...|.|..||.|....|||....    |.||||:.|.....| 
Human   148 HDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINR----PNVSGATPLYFACSH- 207

  Fly  4435 GIMQDRFTAEHVIISAPK------NAKP-----------TCELQL-------PSMKKLMSNSSAQ 4475
               ..|.||:.:::...|      ...|           |||:.:       .::.::..|...:
Human   208 ---GQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETCEVLIQYHPRLFQTIIQMTQNEDLR 269

  Fly  4476 PYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSAST- 4539
            ...||  ::...:....|:|. |.....:|..|..|...::.:..:..|...|...:....... 
Human   270 ENMLR--QVLEHLSQQSESQY-LKILTSLAEVATTNGHKLLSLSSNYDAQMKSLLRIVRMFCHVF 331

  Fly  4540 -ISPPPPMETNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVLWNTLSEC 4603
             |.|..|.....:..:|:.                   ...|:..||       |::||::|.|.
Human   332 RIGPSSPSNGIDMGYNGNK-------------------TPRSQVFKP-------LELLWHSLDEW 370

  Fly  4604 LVAL-------EESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGA 4661
            ||.:       :....|...::|                  |:.|:.  .:||........|.|:
Human   371 LVLIATELMKNKRDSTEITSILL------------------KQKGQD--QDAASIPPFEPPGPGS 415

  Fly  4662 IGGLGA----AAPSA----QEYSPFMDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAM 4718
            ...|..    :.|.|    ||.|....||.|......::......|..:....|.:|:|      
Human   416 YENLSTGTRESKPDALAGRQEASADCQDVISMTANRLSAVIQAFYMCCSCQMPPGMTSP------ 474

  Fly  4719 SAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDH-----------TRILDFD 4772
                        :|::|..||..||...:.::|        .::.||           :|.:.. 
Human   475 ------------RFIEFVCKHDEVLKCFVNRNP--------KIIFDHFHFLLECPELMSRFMHI- 518

  Fly  4773 VKRKYFQTELERLDEGIR-------------REEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFY 4824
            :|.:.|:...|...|.:.             .|...:.|.|.::|..|..|:.:....:.|....
Human   519 IKAQPFKDRCEWFYEHLHSGQPDSDMVHRPVNENDILLVHRDSIFRSSCEVVSKANCAKLKQGIA 583

  Fly  4825 IVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGR 4889
            :.|..|||. ..|::|||:.|:|.||.||.||||..| .|..|:..|.:|:.||:||:||:|.|:
Human   584 VRFHGEEGM-GQGVVREWFDILSNEIVNPDYALFTQS-ADGTTFQPNSNSYVNPDHLNYFRFAGQ 646

  Fly  4890 VIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTE 4954
            ::..|::..:|:..||||||||||||..|.:.|:.|.|.|:.|.|.:::.||||.||.|||||.|
Human   647 ILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVE 711

  Fly  4955 VQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIF 5019
            ...||..:...|||.|....||:.||.||||||.:|:|:.:|:.|::|||:||:..||..||.:|
Human   712 TDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLF 776

  Fly  5020 NEQELELLISGLPDIDIEDLKANTEYHK-YTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKV 5083
            :|.|||||:||:|:||:.|...||||.. |..:...|||||..:....|.:|...||||||:|:|
Human   777 DEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRV 841

  Fly  5084 PLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            |..||.::.|.:|:|.|.|.....:.:.||.:.||.|.|.||.|.|.:.|:..||.|:|..|.|:
Human   842 PHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGY 906

  Fly  5149 GFA 5151
            ..|
Human   907 TMA 909

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033 157/353 (44%)
HECTc 4820..5148 CDD:214523 151/328 (46%)
HACE1NP_065822.2 Ank_2 <27..>283 CDD:330894 46/265 (17%)
ANK 1 64..93 6/28 (21%)
ANK repeat 66..95 CDD:293786 6/28 (21%)
ANK 92..217 CDD:238125 28/132 (21%)
ANK repeat 97..128 CDD:293786 3/30 (10%)
ANK 2 97..126 3/28 (11%)
ANK repeat 130..161 CDD:293786 7/30 (23%)
ANK 3 130..159 7/28 (25%)
ANK repeat 163..194 CDD:293786 8/34 (24%)
ANK 4 163..192 8/28 (29%)
ANK 5 196..226 9/33 (27%)
ANK repeat 196..221 CDD:293786 8/28 (29%)
ANK 6 228..257 4/28 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..433 7/36 (19%)
HECTc 554..903 CDD:238033 155/350 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D140374at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11254
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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