DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and SMURF1

DIOPT Version :10

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_065162.1 Gene:SMURF1 / 57154 HGNCID:16807 Length:757 Species:Homo sapiens


Alignment Length:465 Identity:175/465 - (37%)
Similarity:260/465 - (55%) Gaps:49/465 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly  4701 DASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHL-SDGPFAVLVD 4764
            |.:..|...|:|.....|: |:.||::..|                    |..| |:|       
Human   326 DHNNRTTQFTDPRLHHIMN-HQCQLKEPSQ--------------------PLPLPSEG------- 362

  Fly  4765 HTRILDFDVKRKYFQTELERLDEGIRRE---------EHTVSVRRVTVFEDSFRVLYRLGPEEWK 4820
              .:.|.::..:.::.:|.:..:.:|.|         ...:.|.|..:||:|:|.:.::.|::.|
Human   363 --SLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLK 425

  Fly  4821 NRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFK 4885
            .|..:.|..|||.|.||:.|||..::..|:.||.|.||..|..:.....|||.|..||:|||||.
Human   426 KRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFH 490

  Fly  4886 FVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELT 4950
            ||||::..||.....:...||..|||.:|||.::.:|:||.|.|.:|.|.::::|||:.: .:.|
Human   491 FVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHT 554

  Fly  4951 FSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHL 5015
            |..|...||.....:||||||:..||||||.|||:|....:....|..|..|..:||.::||:||
Human   555 FCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHL 619

  Fly  5016 ISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGT 5080
            :..|:::||||:|.||..||:.|.|:||......:.|..::|||:|:.:||:..||:.||||||:
Human   620 LKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGS 684

  Fly  5081 SKVPLQGFGSLEGMNGI---QKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIH 5142
            ::||||||.:|:|..|.   :.|.||..|.:||.||.||||||::|:|.|:||:||...||.|:.
Human   685 TRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 749

  Fly  5143 E-CSEGFGFA 5151
            | |    |||
Human   750 ETC----GFA 755

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:428721
DUF913 621..989 CDD:461803
UBA_like_SF 1467..1506 CDD:473871
WWE 1756..1828 CDD:128922
DUF5585 3288..3672 CDD:465521
UBM 3670..3700 CDD:464159
UBM 3719..3746 CDD:464159
HECTc 4796..5149 CDD:238033 155/356 (44%)
SMURF1NP_065162.1 C2_Smurf-like 14..138 CDD:176028
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..237
WW 236..267 CDD:197736
WW 307..339 CDD:197736 4/12 (33%)
HECTc 399..754 CDD:238033 155/359 (43%)
Blue background indicates that the domain is not in the aligned region.

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