DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and plekha7a

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_001129715.1 Gene:plekha7a / 571486 ZFINID:ZDB-GENE-050419-75 Length:1197 Species:Danio rerio


Alignment Length:1464 Identity:260/1464 - (17%)
Similarity:429/1464 - (29%) Gaps:562/1464 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  2925 AQAEAYLYERLGSGLMPTPPVGFRVRMNSSIAQPLDIDVNGG-----NAGSGSNAGATGSSGGS- 2983
            |:|..:|:.|.|                    ||    ||.|     :..||...|.| ..|.| 
Zfish    31 ARATTWLHPRTG--------------------QP----VNSGHMIRSDLPSGWEEGFT-KEGASF 70

  Fly  2984 ----GQRSSTGGTTASIGAIASAALRPSSGSWMAPDFNFIRISGGDSSMGSGPAIGGNANGGDMN 3044
                .||::|             .:.|.:|.        |.....|..:...|       ||.| 
Zfish    71 FIDHNQRTTT-------------FIHPVTGQ--------ISTENSDFRLQDQP-------GGRM- 106

  Fly  3045 VFITPSMSLERAGGAPGSGQTMSELLNEQPTGAGGGGGGGSASG-VGGVGANGGTTGQHPNATLC 3108
             ...||.::..|          |..:......:..|..|..:|| |...|.......::|: .:.
Zfish   107 -LKQPSSTISEA----------STTVTTSTVDSTSGSKGSRSSGRVHSFGKRDHAIKRNPSXPVV 160

  Fly  3109 ---------TNGVR--RRLLYLDQQYC---------------VCMPTHQ----NP---------- 3133
                     ::|:|  :|..::...:|               :.:|::.    .|          
Zfish   161 VRGWLYKQDSSGMRLWKRKWFVLADFCLFYYKDSREESVLGSIPLPSYTIAPVGPEDHISRKYAF 225

  Fly  3134 -TEETQMETF-----TQDALHWW---LEEATLLDMESQTDACLYAAHFLLPHLIKELKAAHQQR- 3188
             .|.|.|.|:     ||:.::.|   :.:|.|:    ||            |.:|..:..|... 
Zfish   226 KAEHTGMRTYYFSADTQEDMNGWVRAMNQAALM----QT------------HTVKRDECGHPDHV 274

  Fly  3189 KQEEAARQSTTPASGSNASATSSSTTSVVGTAAPTATSSIASGLLANAVSAGSGSSSLVVPP--- 3250
            ...|..::...|           .|..:.....|......:.||..:......|...:.|.|   
Zfish   275 NVSEKLKKQAVP-----------QTNHINSYVIPKPEVIQSDGLPEDKREGFVGEVEIQVTPREM 328

  Fly  3251 -VAASATGGTRRSSIPVLISSTLGPSSASSATSATGNGATSDATTTTGGPTRNFSSVDSNVSSET 3314
             .|...:..:|...:.||...:..||..:|.       |.|.|.:|.....||.:.::.|     
Zfish   329 EQARGKSPASRVVEVEVLAPGSTPPSRVASR-------APSRAVSTPPVVQRNGTPIEQN----- 381

  Fly  3315 QTTTRPPRQRGGLRQQSQLPFNIYAEIDL--------TNEQDSEGDRSTSTTT-----------G 3360
               ..|..|||. ...:|.|..:.....|        ..:::..|..||.:|.           |
Zfish   382 ---GMPGCQRGA-TPSAQTPVQVQRRSTLEQVENWVKVQKEERHGLVSTESTVPRRTPPIHPKYG 442

  Fly  3361 TAADGAESQSQHNSSSTAAQVAVPQHQRHPPVPLLPSSGRPSRPHTRLDETELLLLQLTDRQIRN 3425
            | .|..:|..:.:..|..|    |.||       |||..:.|  |.||                |
Zfish   443 T-MDKYQSLPKTSRQSPPA----PHHQ-------LPSEYKYS--HDRL----------------N 477

  Fly  3426 RLQGSSGHTNSSRTSGSA---LINARPNRDLPACLQRHDHPAGSIFPRPSANRTPAPTLVSMPTP 3487
            ..|...|||....|..:.   |...:..:..     ||..|...::       ||||...:..:.
Zfish   478 HFQKIHGHTKRPTTHDNTVWQLFEWQQRQQF-----RHGSPFAPVY-------TPAPDYSTAVSS 530

  Fly  3488 MSNAALEQLNVTAPDVVRTDRNFALPSSLEVDVDVLPGIVDLPQQEAQPEDDQLLLPPPPPPPPS 3552
            ..|         .|||.|:             |.|.|.:.|:                 |||.| 
Zfish   531 TRN---------NPDVSRS-------------VSVPPTLADI-----------------PPPGP- 555

  Fly  3553 DTTPLVHAEDDLWPGTVVSAGTREESSAPAVATESTEAVNESNQPEPTPESSESTSPNP----QA 3613
                         ||..:.:..|..:.|..|.....|       ..|..|...|.||:.    ::
Zfish   556 -------------PGARLMSPRRPHTPAERVTVRPLE-------DRPIVEVPPSNSPHRLRSYKS 600

  Fly  3614 PSAEPTPLEPGAAVDASVGAQTPATTEEAASTA-------------GASGTTATITDMSPEVRAA 3665
            .:.|...:.|.|.:..:|.|  |:...:.|...             ..|||.|.....:..|:.|
Zfish   601 ATIERRSMPPSAYITHTVSA--PSLRGKTADDTYMHLKKGLEYLDLKVSGTEALKGRPAKPVKVA 663

  Fly  3666 LGDLEVPEGVDPSFLAALPSEMREEVIQE-HLRMQRIRQRAQ--QNAIQIAHDSLVEVNPEFLAA 3727
            ..|::|.       |:.|..:  ::::|| ..|:..::....  ::.:.::|..:.:...:    
Zfish   664 ESDVDVT-------LSRLCEQ--DKILQELEFRLSGLKDDKDKLESVLDVSHQQMEQYKDQ---- 715

  Fly  3728 LPLNIQSEVLMQQRIEQQ----------RQAAQTANPEDPVDTAAFFQNLPENLRQAILTDMEES 3782
             |.: ..::..|||:.|:          |.:.:.....|  |.:...|:: |.||..:.|.|   
Zfish   716 -PSH-TDKIAYQQRLLQEDLVHIRADISRVSTEMERAWD--DYSGMEQSV-EQLRDVLQTQM--- 772

  Fly  3783 QIASLPPELAAEAQFLRRDWESRNGARMDAHPPSNALSRFQTTLQSLDDTRWHSSIWYDASGNAQ 3847
            .:.:.|.|   :.|..|..|                  |.:..:..|..|:....|..|:..|.:
Zfish   773 TLCTSPQE---KNQLKRELW------------------RMEDVMTGLSSTKETFKITVDSVKNPE 816

  Fly  3848 --------------------------PQHH----------QHTTIVHQHPHAHHAPNMGK----- 3871
                                      ||..          .:..:.::||    .||..:     
Zfish   817 RKLVPSVIESTVPSRCMTPSAAEVRSPQRSLTSSPLSLPLDNEDLRNRHP----VPNWEEDDAPP 877

  Fly  3872 --PLALLMMEDENILLDPDSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTR----------- 3923
              ||.||..||...::.|             ..|..|:..|..:|.|......|           
Zfish   878 RPPLPLLYDEDTPPVVPP-------------LPKETSVIRHTSVRGLKRQSDERKRDRESSYSNG 929

  Fly  3924 DWIISALISIIQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGYKSNI------------------ 3970
            |:.:. |.|.:.:.....:..||...  .|.:|.|:.....|..|.|                  
Zfish   930 DYRLE-LRSYLSEPELPVSAHGADHV--DPGYLTLQRRGLSGSSSRINQYGVASCSLRRDLELST 991

  Fly  3971 -----FLINRLYEGSAR-SISINPQAAQMIVRNCLDLL------FVLAK----------HYPSSF 4013
                 ..:.||..|..: .....||..:|.|...|:.:      .|..:          |..:|.
Zfish   992 MERPKSALERLCSGEPQLEQQSQPQRVRMSVEEQLERMKRHQRALVRERKRNLSQGERHHSRAST 1056

  Fly  4014 VPFNRD-------------------VKARRILSAVFGMPSPTAGSGGGAGSGSAASGGLTGYDDV 4059
            .|.|.|                   |:||.::.:                             ::
Zfish  1057 RPVNSDPGSALFVEPHRPASDEWLTVRARPVMES-----------------------------EL 1092

  Fly  4060 PPGGTLDFRSRFCRYQVVNRL---------RSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAK 4115
            .|   |||     .:.:...|         :.:.||..        ||.||..: ...::...||
Zfish  1093 EP---LDF-----EFDITRELSTPQKVWIPQRLIDDES--------DEDPSPEE-KETRSRTVAK 1140

  Fly  4116 VSTAGSQNKHSVPYQTNAKNFWDVVLNIDQQTQV 4149
            :.|..|:   |....:...:|.|:.|.:.||.::
Zfish  1141 IKTLLSK---SSMRSSEQMDFSDLDLALQQQERI 1171

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740 17/92 (18%)
DUF4414 3675..3779 CDD:291075 19/116 (16%)
HECTc 4796..5149 CDD:238033
HECTc 4820..5148 CDD:214523
plekha7aNP_001129715.1 WW 55..84 CDD:278809 9/42 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 98..148 14/68 (21%)
PH_PEPP1_2_3 153..256 CDD:270068 14/102 (14%)
PH 159..255 CDD:278594 13/95 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 348..384 10/50 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 423..467 13/55 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 508..577 25/133 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 830..928 19/114 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1032..1064 6/31 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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